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公开(公告)号：CA2888308A1
公开(公告)日：2014-05-01
申请号：CA2888308
申请日：2013-10-22
Applicant: FLUIDIGM CANADA INC
Inventor： BARANOV VLADIMIR
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
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公开(公告)号：CA2888308C
公开(公告)日：2021-01-19
申请号：CA2888308
申请日：2013-10-22
Applicant: FLUIDIGM CANADA INC
Inventor： BARANOV VLADIMIR
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
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公开(公告)号：CA2913806A1
公开(公告)日：2014-12-04
申请号：CA2913806
申请日：2014-05-22
Applicant: FLUIDIGM CANADA INC
Inventor： BANDURA DMITRY , BARANOV VLADIMIR , LOBODA ALEXANDER , ORNATSKY OLGA , TANNER SCOTT D
IPC: G01N27/62 , G01N33/483
Abstract: The invention relates to methods and devices for molecular cytometry. The molecular cytometer is for use in the analysis of molecular tag labeled particles. In the molecular cytometer, volatile molecular tags attached to the particles, such as cells, are released as groups of molecular tags and ionized by the method of soft ionization to produce corresponding groups of molecular ions. The molecular cytometer has two detectors, one to detect the presence of the groups of molecular ions and the other to detect mobility separated molecular ions. The mobility separated molecular ions are synchronized to correspond with the groups of molecular ions.
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公开(公告)号：CA3134973A1
公开(公告)日：2020-10-01
申请号：CA3134973
申请日：2020-03-27
Applicant: FLUIDIGM CANADA INC
Inventor： LI STEPHEN K H , MAJONIS DANIEL , BARANOV VLADIMIR , ORNATSKY OLGA , ALLO BEDILU , BANDURA DMITRY , THOM COLIN , STELZER GREG , LOBODA ALEXANDER
Abstract: A lyophilized antibody panel is disclosed for interrogation using elemental analysis. The antibody panel includes multiple antibodies each element-tagged or element-labelled with one or more isotopes such that each different antibody is isotopically distinguishable from the other antibodies. Each element tag can include one or more unique isotopes or unique combinations of isotopes. The set of element-tagged antibodies can be lyophilized in admixture. Thus, the lyophilized element-tagged antibody panel can be easily and efficiently resuspended and mixed with a sample prior to interrogation with an elemental analyzer, such as a mass spectrometer. This lyophilized element-tagged antibody panel can provide the benefits of an element-tagged assay while also being easy to use and remaining stable for long durations.
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公开(公告)号：CA3112016A1
公开(公告)日：2020-03-19
申请号：CA3112016
申请日：2019-09-09
Applicant: FLUIDIGM CANADA INC , GOVERNING COUNCIL UNIV TORONTO
Inventor： CLOSSON TAUNIA , BARANOV VLADIMIR , WINNIK MITCHELL A
Abstract: This disclosure relates to reagents and their use for elemental imaging mass spectrometry of biological samples.
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Patent Agency Ranking
公开(公告)号：CA3097002A1
公开(公告)日：2019-10-17
申请号：CA3097002
申请日：2019-04-12
Applicant: FLUIDIGM CANADA INC
Inventor： BARANOV VLADIMIR , LOBODA ALEXANDER , SULLIVAN MICHAEL
Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.
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公开(公告)号：SG11201503038RA
公开(公告)日：2015-05-28
申请号：SG11201503038R
申请日：2013-10-22
Applicant: FLUIDIGM CANADA INC
Inventor： BARANOV VLADIMIR
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
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公开(公告)号：CA3098578A1
公开(公告)日：2019-10-31
申请号：CA3098578
申请日：2019-04-26
Applicant: FLUIDIGM CANADA INC
Inventor： ZABINYAKOV NIKITA , LOBODA ALEXANDER V , ORNATSKY OLGA , BARANOV VLADIMIR , MAVROPOULOS ANASTASIA , MAJONIS DANIEL , ALLO BEDILU , CLOSSON TAUNIA
Abstract: Embodiments of the present invention relate to reagents and their use for elemental imaging mass spectrometry of biological samples. The embodiments comprising methods for quantifying one or more analytes within a sample, comprising the steps of: (a) providing the sample, wherein the one or more analytes are immobilized to a sample carrier, wherein the sample has been labelled with one or more mass tags comprising one or more labelling atoms, (b) performing mass cytometry on the sample to determine the level of the one or more labelling atoms, wherein the level of the one or more labelling atoms corresponds to the copy number of the one or more analytes.
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公开(公告)号：HK1248739A1
公开(公告)日：2018-10-19
申请号：HK18108653
申请日：2018-07-04
Applicant: FLUIDIGM CANADA INC
Inventor： WINNIK MITCHELL A , NITZ MARK , BARANOV VLADIMIR , LOU XUDONG
IPC: C08F20060101 , G01N20060101
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公开(公告)号：ES2553141T3
公开(公告)日：2015-12-04
申请号：ES11008035
申请日：2007-05-28
Applicant: FLUIDIGM CANADA INC
Inventor： WINNIK MITCHELL , NITZ MARK , BARANOV VLADIMIR , LOU XUDONG
IPC: G01N33/53 , C08F8/42 , C08F220/36
Abstract: Un método para el análisis de un analito, que comprende: (i) incubar un analito con un marcador elemental o un reactivo de afinidad con marcaje elemental, en donde el marcador elemental o el reactivo de afinidad se une con el analito, en donde, el marcador elemental comprende un polímero, o el reactivo de afinidad con marcaje elemental es marcado con un marcador elemental que comprende un polímero, en donde, el polímero comprende al menos un grupo colgante de unión a metal, que comprende al menos un átomo de metal o es capaz de unirse a al menos un átomo de metal; (ii) separar el reactivo de afinidad marcado no unido del reactivo de afinidad marcado unido o elementos de marcador no unidos de los elementos de marcador unidos; y (iii) analizar el elemento unido al reactivo de afinidad unido al analito o elementos de marcador unidos mediante análisis elemental.
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