公开(公告)号：WO2011143659A3

公开(公告)日：2012-07-12

申请号：PCT/US2011036670

申请日：2011-05-16

Applicant: FLUIDIGM CORP ,  MAY ANDREW ,  MIR ALAIN ,  RAMAKRISHNAN RAMESH ,  ZIMMERMANN BERNHARD

Inventor： MAY ANDREW ,  MIR ALAIN ,  RAMAKRISHNAN RAMESH ,  ZIMMERMANN BERNHARD

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12P19/34 ,  C07H21/00 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q2600/118 ,  C12Q2565/113 ,  C12Q2527/125 ,  C12Q2525/204 ,  C12Q2525/307 ,  C12Q2525/15 ,  C12Q2521/507

Abstract: The present invention provides methods for selectively enriching a biological sample for short nucleic acids, such as fetal DNA in a maternal sample or apoptic DNA in a biological sample from a cancer patient and for subsequently analyzing the short nucleic acids for genotype, mutation, and/or aneuploidy.

Abstract translation: 本发明提供了用于选择性富集来自癌症患者的生物样品中的母体样品中的短核酸例如胎儿DNA的生物样品或随机分析用于基因型，突变和/ 或非整倍体。

公开(公告)号：EP2569453A4

公开(公告)日：2013-11-20

申请号：EP11781412

申请日：2011-05-16

Applicant: FLUIDIGM CORP

Inventor： MAY ANDREW ,  MIR ALAIN ,  RAMAKRISHNAN RAMESH ,  ZIMMERMANN BERNHARD

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12P19/34 ,  C07H21/00 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q2600/118 ,  C12Q2565/113 ,  C12Q2527/125 ,  C12Q2525/204 ,  C12Q2525/307 ,  C12Q2525/15 ,  C12Q2521/507

Abstract: The present invention provides methods for selectively enriching a biological sample for short nucleic acids, such as fetal DNA in a maternal sample or apoptic DNA in a biological sample from a cancer patient and for subsequently analyzing the short nucleic acids for genotype, mutation, and/or aneuploidy.

Abstract translation: 本发明提供了选择性富集生物样品的方法，所述生物样品用于短核酸，例如母体样品中的胎儿DNA或来自癌症患者的生物样品中的凋亡DNA，并随后分析短核酸的基因型，突变和/ 或非整倍体。

公开(公告)号：SG185544A1

公开(公告)日：2012-12-28

申请号：SG2012083432

申请日：2011-05-16

Applicant: FLUIDIGM CORP

Inventor： MAY ANDREW ,  MIR ALAIN ,  RAMAKRISHNAN RAMESH ,  ZIMMERMANN BERNHARD

Abstract: The present invention provides methods for selectively enriching a biological sample for short nucleic acids, such as fetal DNA in a maternal sample or apoptic DNA in a biological sample from a cancer patient and for subsequently analyzing the short nucleic acids for genotype, mutation, and/or aneuploidy.