公开(公告)号：CA3058127C

公开(公告)日：2022-07-05

申请号：CA3058127

申请日：2018-03-30

Applicant: FUJIFILM CORP

Inventor： KASAGI NORIYUKI ,  YAMADA NAOKI ,  MORI MIKINAGA ,  KATO TAKAYUKI ,  KOBAYASHI TAKAYUKI

IPC: A61K9/127 ,  A61K31/404 ,  A61K31/4745 ,  A61K31/704 ,  A61K47/04 ,  A61K47/24 ,  A61K47/28 ,  A61P35/00

Abstract: The present invention addresses the problem of providing a liposome composition and a pharmaceutical composition that exhibit a high AUC. The present invention provides: a liposome composition that contains, as constituent components of the liposome membrane, a diacylphosphatidylethanolamine modified by a hydrophilic polymer, a dihydrosphingomyelin, and cholesterols; and a pharmaceutical composition containing the liposome composition, wherein the liposome composition encapsulates a drug, an inner aqueous phase thereof contains ammonium sulfate, and the molar ratio of sulfate ions in the inner aqueous phase to the drug in the entire aqueous phase is equal to or greater than 0.36.

公开(公告)号：RU2734900C1

公开(公告)日：2020-10-26

申请号：RU2019130500

申请日：2018-03-30

Applicant: FUJIFILM CORP

Inventor： KASAGI NORIYUKI ,  YAMADA NAOKI ,  MORI MIKINAGA ,  KATO TAKAYUKI ,  KOBAYASHI TAKAYUKI

IPC: A61K31/704 ,  A61K9/127 ,  A61K47/04 ,  A61K47/24 ,  A61K47/28 ,  A61P35/00

Abstract: Группаизобретенийотноситсяк областимедицины, аименнок липосомальнойкомпозициидляинкапсулированиялекарственногосредства, включающей: липосомы, каждаяизкоторыхимеетвнутреннююводнуюфазу, иводныйраствор, которыйсоставляетвнешнююводнуюфазуи вкоторомдиспергированылипосомы, гделипосомавключаетгидрофильныйполимер–модифицированныйдиацилфосфатидилэтаноламин; дигидросфингомиелин; ихолестерины; гдекаждаялипосомакомпозицииинкапсулируетлекарственноесредство; гдегидрофильныйполимер–модифицированныйдиацилфосфатидилэтаноламинпредставляетсобойполиэтиленгликоль–илиметоксиполиэтиленгликоль–модифицированныйдиацилфосфатидилэтаноламин; гдедигидросфингомиелинпредставляетсобойдигидросфингомиелин, имеющийдлинноцепочечнуюалкильнуюгруппу, содержащую 16 атомовуглерода, идлинноцепочечнуюалкильнуюгруппу, содержащую 18 атомовуглерода; гделекарственноесредствопредставляетсобойпротивораковоелекарственноесредство; гдевнутренняяводнаяфазасодержитсульфатаммония, имолярноеотношениесульфат–ионоввовнутреннейводнойфазек суммелекарственногосредствавовнутреннейводнойфазеи вовнешнейводнойфазесоставляет 0,36 илибольше, атакжеотноситсяк способулеченияраковогозаболевания. Группаизобретенийобеспечиваетполучениекомпозиции, котораядемонстрируетвысокиезначения AUC. 5 н. и 11 з.п. ф-лы, 6 ил., 7 табл.

公开(公告)号：HK1210155A1

公开(公告)日：2016-04-15

申请号：HK15110899

申请日：2015-11-04

Applicant: FUJIFILM CORP

Inventor： FURUYAMA HIDETOMO ,  KURIHARA HIDEKI ,  TERAO TAKAHIRO ,  NAKAGAWA DAISUKE ,  TANABE SHINTARO ,  KATO TAKAYUKI ,  YAMAMOTO MASAHIKO ,  SEKINE SHINICHIRO ,  MASHIKO TOMOYUKI ,  INUKI SHINSUKE ,  UEDA SATOSHI

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101

公开(公告)号：EP2944637A4

公开(公告)日：2015-11-18

申请号：EP14737606

申请日：2014-01-14

Applicant: FUJIFILM CORP

Inventor： FURUYAMA HIDETOMO ,  KURIHARA HIDEKI ,  TERAO TAKAHIRO ,  NAKAGAWA DAISUKE ,  TANABE SHINTARO ,  KATO TAKAYUKI ,  YAMAMOTO MASAHIKO ,  SEKINE SHINICHIRO ,  MASHIKO TOMOYUKI ,  INUKI SHINSUKE ,  UEDA SATOSHI

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61P3/00 ,  A61P5/00 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: A compound represented by Formula [1] (in the formula, Z 1 represents N, CH, or the like; X 1 represents NH or the like; R 1 represents a heteroaryl group or the like; each of R 2 , R 3 , and R 4 represents a hydrogen atom, a halogen atom, an alkoxy group, or the like; and R 5 represents a heteroaryl group or the like) or salt thereof.

公开(公告)号：SG178526A1

公开(公告)日：2012-03-29

申请号：SG2012012027

申请日：2010-08-17

Applicant: FUJIFILM CORP

Inventor： SHIBUYA AKINORI ,  YAMAGUCHI SHUHEI ,  KATAOKA SHOHEI ,  SHIRAKAWA MICHIHIRO ,  KATO TAKAYUKI ,  TANGO NAOHIRO

Abstract: An actinic ray-sensitive or radiation-sensitive resin composition including: (PA) a compound having a proton acceptor functional group and undergoing decomposition upon irradiation with an actinic ray or radiation to generate a compound reduced in or deprived of proton acceptor property or changed to be acidic from being proton acceptor-functioning, wherein a molar extinction coefficient e of the compound (PA) at a wavelength of 193 nm as measured in acetonitrile solvent is 55,000 or less, and a pattern forming method using the composition are provided.

公开(公告)号：AU2018246024B2

公开(公告)日：2020-08-06

申请号：AU2018246024

申请日：2018-03-30

Applicant: FUJIFILM CORP

Inventor： KASAGI NORIYUKI ,  YAMADA NAOKI ,  MORI MIKINAGA ,  KATO TAKAYUKI ,  KOBAYASHI TAKAYUKI

IPC: A61K9/127 ,  A61K31/404 ,  A61K31/4745 ,  A61K31/704 ,  A61K47/04 ,  A61K47/24 ,  A61K47/28 ,  A61P35/00

Abstract: The present invention addresses the problem of providing a liposome composition and a pharmaceutical composition that exhibit a high AUC. The present invention provides: a liposome composition that contains, as constituent components of the liposome membrane, a diacylphosphatidylethanolamine modified by a hydrophilic polymer, a dihydrosphingomyelin, and cholesterols; and a pharmaceutical composition containing the liposome composition, wherein the liposome composition encapsulates a drug, an inner aqueous phase thereof contains ammonium sulfate, and the molar ratio of sulfate ions in the inner aqueous phase to the drug in the entire aqueous phase is equal to or greater than 0.36.

公开(公告)号：AU2018246024A1

公开(公告)日：2019-10-17

申请号：AU2018246024

申请日：2018-03-30

Applicant: FUJIFILM CORP

Inventor： KASAGI NORIYUKI ,  YAMADA NAOKI ,  MORI MIKINAGA ,  KATO TAKAYUKI ,  KOBAYASHI TAKAYUKI

IPC: A61K9/127 ,  A61K31/404 ,  A61K31/4745 ,  A61K31/704 ,  A61K47/04 ,  A61K47/24 ,  A61K47/28 ,  A61P35/00

Abstract: The present invention addresses the problem of providing a liposome composition and a pharmaceutical composition that exhibit a high AUC. The present invention provides: a liposome composition that contains, as constituent components of the liposome membrane, a diacylphosphatidylethanolamine modified by a hydrophilic polymer, a dihydrosphingomyelin, and cholesterols; and a pharmaceutical composition containing the liposome composition, wherein the liposome composition encapsulates a drug, an inner aqueous phase thereof contains ammonium sulfate, and the molar ratio of sulfate ions in the inner aqueous phase to the drug in the entire aqueous phase is equal to or greater than 0.36.

公开(公告)号：CA3058127A1

公开(公告)日：2018-10-04

申请号：CA3058127

申请日：2018-03-30

Applicant: FUJIFILM CORP

Inventor： KASAGI NORIYUKI ,  YAMADA NAOKI ,  MORI MIKINAGA ,  KATO TAKAYUKI ,  KOBAYASHI TAKAYUKI

IPC: A61K9/127 ,  A61K31/404 ,  A61K31/4745 ,  A61K31/704 ,  A61K47/04 ,  A61K47/24 ,  A61K47/28 ,  A61P35/00

Abstract: The present invention addresses the problem of providing a liposome composition and a pharmaceutical composition that exhibit a high AUC. The present invention provides: a liposome composition that contains, as constituent components of the liposome membrane, a diacylphosphatidylethanolamine modified by a hydrophilic polymer, a dihydrosphingomyelin, and cholesterols; and a pharmaceutical composition containing the liposome composition, wherein the liposome composition encapsulates a drug, an inner aqueous phase thereof contains ammonium sulfate, and the molar ratio of sulfate ions in the inner aqueous phase to the drug in the entire aqueous phase is equal to or greater than 0.36.

公开(公告)号：EP2338089A4

公开(公告)日：2013-02-27

申请号：EP09816316

申请日：2009-09-29

Applicant: FUJIFILM CORP

Inventor： FUKUHARA TOSHIAKI ,  SHIBUYA AKINORI ,  KATO TAKAYUKI

IPC: G03F7/039 ,  C08F20/26 ,  C08F20/28 ,  C08F20/34 ,  G03F7/004 ,  G03F7/20 ,  G03F7/38 ,  H01L21/027

CPC classification number: C08F20/28 ,  C08F20/26 ,  G03F7/0045 ,  G03F7/0046 ,  G03F7/0397 ,  G03F7/2041 ,  Y10S430/111

公开(公告)号：EP2414897A4

公开(公告)日：2012-08-08

申请号：EP10758922

申请日：2010-03-30

Applicant: FUJIFILM CORP

Inventor： KATO TAKAYUKI ,  SAEGUSA HIROSHI ,  IWATO KAORU ,  HIRANO SHUJI ,  IIZUKA YUSUKE ,  YAMAGUCHI SHUBEL ,  SHIBUYA AKINORI

IPC: G03F7/039 ,  G03F7/004 ,  G03F7/075 ,  G03F7/20 ,  H01L21/027

CPC classification number: G03F7/0046 ,  G03F7/0397 ,  G03F7/0758 ,  G03F7/2041