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公开(公告)号：PL3235561T3
公开(公告)日：2019-06-28
申请号：PL15870074
申请日：2015-12-18
Applicant: FUJIFILM CORP
Inventor： SUGIYAMA SUSUMU , YAMADA NAOKI , SUGIYAMA SHIGEHISA , OKUBO YOHEI
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公开(公告)号：AU2018246024B2
公开(公告)日：2020-08-06
申请号：AU2018246024
申请日：2018-03-30
Applicant: FUJIFILM CORP
Inventor： KASAGI NORIYUKI , YAMADA NAOKI , MORI MIKINAGA , KATO TAKAYUKI , KOBAYASHI TAKAYUKI
IPC: A61K9/127 , A61K31/404 , A61K31/4745 , A61K31/704 , A61K47/04 , A61K47/24 , A61K47/28 , A61P35/00
Abstract: The present invention addresses the problem of providing a liposome composition and a pharmaceutical composition that exhibit a high AUC. The present invention provides: a liposome composition that contains, as constituent components of the liposome membrane, a diacylphosphatidylethanolamine modified by a hydrophilic polymer, a dihydrosphingomyelin, and cholesterols; and a pharmaceutical composition containing the liposome composition, wherein the liposome composition encapsulates a drug, an inner aqueous phase thereof contains ammonium sulfate, and the molar ratio of sulfate ions in the inner aqueous phase to the drug in the entire aqueous phase is equal to or greater than 0.36.
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公开(公告)号：AU2018246024A1
公开(公告)日：2019-10-17
申请号：AU2018246024
申请日：2018-03-30
Applicant: FUJIFILM CORP
Inventor： KASAGI NORIYUKI , YAMADA NAOKI , MORI MIKINAGA , KATO TAKAYUKI , KOBAYASHI TAKAYUKI
IPC: A61K9/127 , A61K31/404 , A61K31/4745 , A61K31/704 , A61K47/04 , A61K47/24 , A61K47/28 , A61P35/00
Abstract: The present invention addresses the problem of providing a liposome composition and a pharmaceutical composition that exhibit a high AUC. The present invention provides: a liposome composition that contains, as constituent components of the liposome membrane, a diacylphosphatidylethanolamine modified by a hydrophilic polymer, a dihydrosphingomyelin, and cholesterols; and a pharmaceutical composition containing the liposome composition, wherein the liposome composition encapsulates a drug, an inner aqueous phase thereof contains ammonium sulfate, and the molar ratio of sulfate ions in the inner aqueous phase to the drug in the entire aqueous phase is equal to or greater than 0.36.
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公开(公告)号：CA3058127A1
公开(公告)日：2018-10-04
申请号：CA3058127
申请日：2018-03-30
Applicant: FUJIFILM CORP
Inventor： KASAGI NORIYUKI , YAMADA NAOKI , MORI MIKINAGA , KATO TAKAYUKI , KOBAYASHI TAKAYUKI
IPC: A61K9/127 , A61K31/404 , A61K31/4745 , A61K31/704 , A61K47/04 , A61K47/24 , A61K47/28 , A61P35/00
Abstract: The present invention addresses the problem of providing a liposome composition and a pharmaceutical composition that exhibit a high AUC. The present invention provides: a liposome composition that contains, as constituent components of the liposome membrane, a diacylphosphatidylethanolamine modified by a hydrophilic polymer, a dihydrosphingomyelin, and cholesterols; and a pharmaceutical composition containing the liposome composition, wherein the liposome composition encapsulates a drug, an inner aqueous phase thereof contains ammonium sulfate, and the molar ratio of sulfate ions in the inner aqueous phase to the drug in the entire aqueous phase is equal to or greater than 0.36.
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公开(公告)号：CA3058127C
公开(公告)日：2022-07-05
申请号：CA3058127
申请日：2018-03-30
Applicant: FUJIFILM CORP
Inventor： KASAGI NORIYUKI , YAMADA NAOKI , MORI MIKINAGA , KATO TAKAYUKI , KOBAYASHI TAKAYUKI
IPC: A61K9/127 , A61K31/404 , A61K31/4745 , A61K31/704 , A61K47/04 , A61K47/24 , A61K47/28 , A61P35/00
Abstract: The present invention addresses the problem of providing a liposome composition and a pharmaceutical composition that exhibit a high AUC. The present invention provides: a liposome composition that contains, as constituent components of the liposome membrane, a diacylphosphatidylethanolamine modified by a hydrophilic polymer, a dihydrosphingomyelin, and cholesterols; and a pharmaceutical composition containing the liposome composition, wherein the liposome composition encapsulates a drug, an inner aqueous phase thereof contains ammonium sulfate, and the molar ratio of sulfate ions in the inner aqueous phase to the drug in the entire aqueous phase is equal to or greater than 0.36.
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Patent Agency Ranking
公开(公告)号：RU2734900C1
公开(公告)日：2020-10-26
申请号：RU2019130500
申请日：2018-03-30
Applicant: FUJIFILM CORP
Inventor： KASAGI NORIYUKI , YAMADA NAOKI , MORI MIKINAGA , KATO TAKAYUKI , KOBAYASHI TAKAYUKI
Abstract: Группаизобретенийотноситсяк областимедицины, аименнок липосомальнойкомпозициидляинкапсулированиялекарственногосредства, включающей: липосомы, каждаяизкоторыхимеетвнутреннююводнуюфазу, иводныйраствор, которыйсоставляетвнешнююводнуюфазуи вкоторомдиспергированылипосомы, гделипосомавключаетгидрофильныйполимер–модифицированныйдиацилфосфатидилэтаноламин; дигидросфингомиелин; ихолестерины; гдекаждаялипосомакомпозицииинкапсулируетлекарственноесредство; гдегидрофильныйполимер–модифицированныйдиацилфосфатидилэтаноламинпредставляетсобойполиэтиленгликоль–илиметоксиполиэтиленгликоль–модифицированныйдиацилфосфатидилэтаноламин; гдедигидросфингомиелинпредставляетсобойдигидросфингомиелин, имеющийдлинноцепочечнуюалкильнуюгруппу, содержащую 16 атомовуглерода, идлинноцепочечнуюалкильнуюгруппу, содержащую 18 атомовуглерода; гделекарственноесредствопредставляетсобойпротивораковоелекарственноесредство; гдевнутренняяводнаяфазасодержитсульфатаммония, имолярноеотношениесульфат–ионоввовнутреннейводнойфазек суммелекарственногосредствавовнутреннейводнойфазеи вовнешнейводнойфазесоставляет 0,36 илибольше, атакжеотноситсяк способулеченияраковогозаболевания. Группаизобретенийобеспечиваетполучениекомпозиции, котораядемонстрируетвысокиезначения AUC. 5 н. и 11 з.п. ф-лы, 6 ил., 7 табл.
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公开(公告)号：DK3235561T3
公开(公告)日：2019-01-28
申请号：DK15870074
申请日：2015-12-18
Applicant: FUJIFILM CORP
Inventor： SUGIYAMA SUSUMU , YAMADA NAOKI , SUGIYAMA SHIGEHISA , OKUBO YOHEI
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公开(公告)号：EP3235561A4
公开(公告)日：2017-12-13
申请号：EP15870074
申请日：2015-12-18
Applicant: FUJIFILM CORP
Inventor： SUGIYAMA SUSUMU , YAMADA NAOKI , SUGIYAMA SHIGEHISA , OKUBO YOHEI
CPC classification number: A61K9/1277 , A61K9/127 , A61K9/1271 , A61K31/7068 , B01F3/08 , B01F3/0807 , B01F5/0206 , B01F5/10 , B01F2215/0032 , B01J13/04 , B01J13/08 , B82Y5/00 , B82Y40/00
Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
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公开(公告)号：EP3235562A4
公开(公告)日：2017-12-13
申请号：EP15870075
申请日：2015-12-18
Applicant: FUJIFILM CORP
Inventor： SUGIYAMA SUSUMU , YAMADA NAOKI , SUGIYAMA SHIGEHISA , OKUBO YOHEI , SASAKI TAKASHI , ISHIGURO TETSU
IPC: B01J13/04 , A61K9/127 , B01D1/00 , B01D5/00 , B01F3/08 , B01F5/10 , B01F7/00 , B01F7/16 , B01F7/32 , B01F15/02 , B01F15/06
CPC classification number: B01J13/04 , A61K9/127 , A61K9/1271 , A61K9/1277 , B01D1/00 , B01D5/006 , B01F3/0807 , B01F5/10 , B01F7/0075 , B01F2003/0842 , B01F2215/0032
Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
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公开(公告)号：JP2008250233A
公开(公告)日：2008-10-16
申请号：JP2007094815
申请日：2007-03-30
Applicant: Fujifilm Corp , 富士フイルム株式会社
Inventor： YOKOTA KOICHI , FUKUYOSHI TOMONOBU , TAKEUCHI NOBUO , YAMADA NAOKI , YAMAMOTO KENICHI
Abstract: PROBLEM TO BE SOLVED: To provide a silver halide photographic sensitive material which ensures excellent scratch resistance, less falling of a matting agent and less dust deposition during use by a user, and can materialize image formation by which digital information can be recorded with less degradation on the silver halide photographic sensitive material. SOLUTION: The silver halide photographic sensitive material has, on one side of a polyester support, silver halide emulsion layers comprising at least one blue-sensitive layer, at least one green-sensitive layer and at least one red-sensitive layer and a non-photosensitive hydrophilic colloidal layer, and has a conductive antistatic layer and a protective layer disposed in this order on the other side of the support, wherein the protective layer contains diacetylcellulose and a matting agent which is polyacrylonitrile. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供一种卤化银照相感光材料，其确保优异的耐划伤性，较少的消光剂下落和在使用期间减少粉尘沉积，并且可以实现可以记录数字信息的图像形成 卤化银感光材料的降解较少。 解决方案：卤化银感光材料在聚酯载体的一面上具有包含至少一个感蓝层，至少一个感光层和至少一个红敏感层的卤化银乳剂层，和 非感光亲水性胶体层，并且在支撑体的另一侧具有依次设置的导电性抗静电层和保护层，其中保护层含有二乙酰纤维素和作为聚丙烯腈的消光剂。 版权所有（C）2009，JPO＆INPIT
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