公开(公告)号：ZA8901162B

公开(公告)日：1989-10-25

申请号：ZA8901162

申请日：1989-02-15

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  BLUMBACH JUERGEN ,  JUERGEN BLUMBACH ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  FISCHER GERD ,  GERD FISCHER ,  MENCKE BURGHARD ,  BURGHARD MENCKE ,  ISERT DIETER ,  DIETER ISERT ,  SEIBERT GERHARD ,  GERHARD SEIBERT

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/32 ,  C07D501/34 ,  C07D ,  A61K

CPC classification number: C07D501/34 ,  C07D501/00

公开(公告)号：UY23683A1

公开(公告)日：1993-12-17

申请号：UY23683

申请日：1993-12-09

Applicant: HOECHST AG

Inventor： WALTER DUERCKHEIMER ,  DIETER ISERT ,  ROBERT RIPPEL ,  RAMAZAN RANGOONWALA ,  HORST DORNAUER

IPC: A61K31/535 ,  A61P31/00 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C02F1/20 ,  C02F1/28 ,  C02F1/42 ,  C02F1/44 ,  C02F1/469 ,  C07D333/38 ,  C07D333/40 ,  C07D463/00 ,  C07D498/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D505/00

Abstract: Procedimiento para la fabricación de una sal de Cefalosporina de fórmula general (I) (figura 1), caracterizada por el hecho de se mezcla una Cefalosporina (C) como ácido libre en uno o varios componentes básicos (B) en forma de solución o suspensión en agua, en disolventes orgánicos o en mezclas de disolventes, y de que se aisla la sal formada sea por filtración, disminución de la solución por evaporación o liofilización. En realizaciones particulares B representa un derivado tiofénico Articain y se emplea el compuesto Cefotaxim como componente C. Estas sales de Cefalosporinas poseen una buena actividad antibacteriana, y que en virtud de sus ventajosas propiedades farmacocinéticas y fisicoquímicas se adecuan para la utilización y administración por vía parenteral, especialmente intramuscular, en la medicina humana y veterinaria.

公开(公告)号：ZA9004526B

公开(公告)日：1991-03-27

申请号：ZA9004526

申请日：1990-06-12

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  MENCKE BURKHARD ,  BURKHARD MENCKE ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/34 ,  C07D501/56 ,  C07D ,  A61K

CPC classification number: C07D501/00

公开(公告)号：ZA896503B

公开(公告)日：1990-05-30

申请号：ZA896503

申请日：1989-08-25

Applicant: HOECHST AG

Inventor： GERHARD SEIBERT ,  SEIBERT GERHARD ,  DIETER ISERT ,  ISERT DIETER ,  NORBERT KLESEL ,  KLESEL NORBERT

IPC: C07D501/20 ,  A61K38/00 ,  A61K38/14 ,  A61P31/04 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/56 ,  C07D501/59 ,  A61K ,  C07D

Abstract: Decaplanin and cephalosporin derivatives when administered together show a synergistic antibacterial effect. Corresponding combination products are therefore suitable for the prophylaxis and treatment of bacterial infections.

公开(公告)号：ZA8902089B

公开(公告)日：1989-10-25

申请号：ZA8902089

申请日：1989-03-20

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  MENCKE BURGHARD ,  BURGHARD MENCKE ,  KLESEL NORBERT ,  NORBERT KLESEL ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  SELIGER HUBERT ,  HUBERT SELIGER ,  SEIBERT GERHARD ,  GERHARD SEIBERT ,  FISCHER GERD ,  GERD FISCHER ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34 ,  C07D ,  A61K

CPC classification number: C07D501/34

公开(公告)号：MA23490A1

公开(公告)日：1995-10-01

申请号：MA23819

申请日：1995-03-28

Applicant: HOECHST AG

Inventor： RUDOLF LATTRELL ,  PETER HAMMANN ,  DIETER ISERT ,  THEODOR WOLLENANN ,  HOLGER WALLMEIER

IPC: A61K38/08 ,  A61K38/12 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07K7/06 ,  C07K7/56 ,  C07K7/60 ,  C07K14/195 ,  C07K14/41 ,  C07K7/00 ,  A61K37/02

公开(公告)号：LV10278B

公开(公告)日：1995-08-20

申请号：LV920697

申请日：1992-12-23

Applicant: HOECHST AG

Inventor： GERD FISCHER ,  ELISABETH DEFOSSA ,  UWE GERLACH ,  ROLF HORLEIN ,  NORBERT KRASS ,  RUDOLF LATTRELL ,  ULRICH STACHE ,  THEODOR WOLLMANN ,  DIETER ISERT

IPC: A61K31/545 ,  C07D501/34

Abstract: (6R,7R)-7-[2-(aminotiazol-4-il)-2-(Z)-(methoxyimino)-acetamido]-3-(methoxymethyl)-3-cefem-4-carbonacid-1-(isopropiloxycarbonoxy)ethylester diastereomers with formula (I): and physiologically salable salines as well as diastereomeric pure salines of these compositions with formula (II) where HX is marked with monobasic or multi-basic acid, but X - inorganic or organic type physiologically acceptable anion which is very well resolved from within the intestinal path. The production method of these compositions is given based on the firsthand acquisition of intermediate products with formula (III) or (IV):[composition (IV) is composition's (III) with acid HY salt] which with the help of HY acid salines decomposed in pure diastereomers, but they in turn are made into necessary products (I) or (II).

公开(公告)号：AU1706292A

公开(公告)日：1993-03-11

申请号：AU1706292

申请日：1992-05-22

Applicant: HOECHST AG

Inventor： ELIZABETH DEFOSSA ,  GERD FISCHER ,  JOACHIM-HEINER JENDRALLA ,  RUDOLF LATTRELL ,  THEODOR WOLLMANN ,  DIETER ISERT

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B57/00 ,  C07D417/12 ,  C07D501/00 ,  C07D501/12 ,  C07D501/18 ,  C07D501/32 ,  C07D501/34

Abstract: The invention relates to crystalline acid addition salts of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl ester of 3-cephem-4-carboxylic acid of the general formula II in which X represents the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group =N-OH is in the syn position, pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, a process for the preparation of the cephem derivatives, and the use of the cephem derivatives for the control of bacterial infections.

公开(公告)号：ZA905504B

公开(公告)日：1991-04-24

申请号：ZA905504

申请日：1990-07-13

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  SCHEUNEMANN KARL-HEINZ ,  KARL-HEINZ SCHEUNEMANN ,  SEIBERT GERHARD ,  GERHARD SEIBERT ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D277/36 ,  C07D277/56 ,  C07D501/00 ,  C07D501/36 ,  C07D ,  A61K

Abstract: Cephalosporin derivatives of the general formula pharmaceutical preparations active against bacterial infections which contain such cephalosporin derivatives, processes for the preparation of the cephalosporin derivatives, use of the cephalosporin derivatives for the preparation of a pharmaceutical for combating bacterial infections, and starting products for the preparation of cephalosporin derivatives.

公开(公告)号：PH30743A

公开(公告)日：1997-10-17

申请号：PH44890

申请日：1992-09-04

Applicant: HOECHST AG

Inventor： GERD FISCHER ,  ELISABETH DEFOSSA ,  UWE GERLACH ,  ROLF HORLEIN ,  NORBERT KRASS ,  RUDOLF LATTREL ,  ULRICH STACHE ,  THEODOR WOLLMANN ,  DIETER ISERT

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/06 ,  C07D501/34 ,  C07D501/56 ,  C07D501/22

Abstract: Enterally absorbable diastereomers of (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(m ethoxymethyl)-3-cephem-4-carboxylic acid 1-(isopropoxycarbonyloxy)ethyl ester of the formula I and its physiologically acceptable salts and also diastereomerically pure salts of the compounds of the general formula II where HX represents a mono- or polybasic acid and where X represents an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II are described, which is characterised in that on mixing together one equivalent of a solution of the diastereomer mixture of the formula III with 0.2 - 2 equivalents of a solution of the acid component HY the more poorly soluble diastereomer of the general formula IV is first precipitated and separated off by filtration, then the more readily soluble diastereomer of the general formula IV is precipitated from the filtration solution, it being possible in the subsequent subsidiary steps for the acid components HY to be identical or different and any desired sequence of the addition of different acid components HY to be used, and the salts obtained are optionally further purified by crystallisation.