公开(公告)号：ZA8902089B

公开(公告)日：1989-10-25

申请号：ZA8902089

申请日：1989-03-20

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  MENCKE BURGHARD ,  BURGHARD MENCKE ,  KLESEL NORBERT ,  NORBERT KLESEL ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  SELIGER HUBERT ,  HUBERT SELIGER ,  SEIBERT GERHARD ,  GERHARD SEIBERT ,  FISCHER GERD ,  GERD FISCHER ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34 ,  C07D ,  A61K

CPC classification number: C07D501/34

公开(公告)号：ZA8901162B

公开(公告)日：1989-10-25

申请号：ZA8901162

申请日：1989-02-15

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  BLUMBACH JUERGEN ,  JUERGEN BLUMBACH ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  FISCHER GERD ,  GERD FISCHER ,  MENCKE BURGHARD ,  BURGHARD MENCKE ,  ISERT DIETER ,  DIETER ISERT ,  SEIBERT GERHARD ,  GERHARD SEIBERT

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/32 ,  C07D501/34 ,  C07D ,  A61K

CPC classification number: C07D501/34 ,  C07D501/00

公开(公告)号：LV10278B

公开(公告)日：1995-08-20

申请号：LV920697

申请日：1992-12-23

Applicant: HOECHST AG

Inventor： GERD FISCHER ,  ELISABETH DEFOSSA ,  UWE GERLACH ,  ROLF HORLEIN ,  NORBERT KRASS ,  RUDOLF LATTRELL ,  ULRICH STACHE ,  THEODOR WOLLMANN ,  DIETER ISERT

IPC: A61K31/545 ,  C07D501/34

Abstract: (6R,7R)-7-[2-(aminotiazol-4-il)-2-(Z)-(methoxyimino)-acetamido]-3-(methoxymethyl)-3-cefem-4-carbonacid-1-(isopropiloxycarbonoxy)ethylester diastereomers with formula (I): and physiologically salable salines as well as diastereomeric pure salines of these compositions with formula (II) where HX is marked with monobasic or multi-basic acid, but X - inorganic or organic type physiologically acceptable anion which is very well resolved from within the intestinal path. The production method of these compositions is given based on the firsthand acquisition of intermediate products with formula (III) or (IV):[composition (IV) is composition's (III) with acid HY salt] which with the help of HY acid salines decomposed in pure diastereomers, but they in turn are made into necessary products (I) or (II).

公开(公告)号：AU1706292A

公开(公告)日：1993-03-11

申请号：AU1706292

申请日：1992-05-22

Applicant: HOECHST AG

Inventor： ELIZABETH DEFOSSA ,  GERD FISCHER ,  JOACHIM-HEINER JENDRALLA ,  RUDOLF LATTRELL ,  THEODOR WOLLMANN ,  DIETER ISERT

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B57/00 ,  C07D417/12 ,  C07D501/00 ,  C07D501/12 ,  C07D501/18 ,  C07D501/32 ,  C07D501/34

Abstract: The invention relates to crystalline acid addition salts of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl ester of 3-cephem-4-carboxylic acid of the general formula II in which X represents the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group =N-OH is in the syn position, pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, a process for the preparation of the cephem derivatives, and the use of the cephem derivatives for the control of bacterial infections.

公开(公告)号：PH30743A

公开(公告)日：1997-10-17

申请号：PH44890

申请日：1992-09-04

Applicant: HOECHST AG

Inventor： GERD FISCHER ,  ELISABETH DEFOSSA ,  UWE GERLACH ,  ROLF HORLEIN ,  NORBERT KRASS ,  RUDOLF LATTREL ,  ULRICH STACHE ,  THEODOR WOLLMANN ,  DIETER ISERT

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/06 ,  C07D501/34 ,  C07D501/56 ,  C07D501/22

Abstract: Enterally absorbable diastereomers of (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(m ethoxymethyl)-3-cephem-4-carboxylic acid 1-(isopropoxycarbonyloxy)ethyl ester of the formula I and its physiologically acceptable salts and also diastereomerically pure salts of the compounds of the general formula II where HX represents a mono- or polybasic acid and where X represents an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II are described, which is characterised in that on mixing together one equivalent of a solution of the diastereomer mixture of the formula III with 0.2 - 2 equivalents of a solution of the acid component HY the more poorly soluble diastereomer of the general formula IV is first precipitated and separated off by filtration, then the more readily soluble diastereomer of the general formula IV is precipitated from the filtration solution, it being possible in the subsequent subsidiary steps for the acid components HY to be identical or different and any desired sequence of the addition of different acid components HY to be used, and the salts obtained are optionally further purified by crystallisation.

公开(公告)号：ZA9002381B

公开(公告)日：1990-12-28

申请号：ZA9002381

申请日：1990-03-28

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  FISCHER GERD ,  GERD FISCHER ,  MENCKE BURKHARD ,  BURKHARD MENCKE ,  SEIBERT GERHARD ,  GERHARD SEIBERT ,  KLESEL NORBERT ,  NORBERT KLESEL ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/06 ,  C07D501/22 ,  C07D501/34 ,  C07D501/46 ,  C07D ,  A61K

CPC classification number: C07D501/34

公开(公告)号：ZA892089B

公开(公告)日：1989-10-25

申请号：ZA892089

申请日：1989-03-20

Applicant: HOECHST AG

Inventor： ADAM FRIEDHELM ,  FRIEDHELM ADAM ,  MENCKE BURGHARD ,  BURGHARD MENCKE ,  KLESEL NORBERT ,  NORBERT KLESEL ,  DUERCKHEIMER WALTER ,  WALTER DUERCKHEIMER ,  SELIGER HUBERT ,  HUBERT SELIGER ,  SEIBERT GERHARD ,  GERHARD SEIBERT ,  FISCHER GERD ,  GERD FISCHER ,  ISERT DIETER ,  DIETER ISERT

IPC: A61K20060101 ,  A61K31/425 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B41M5/155 ,  B41M5/26 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/24 ,  C07D501/34 ,  C07D ,  A61K

Abstract: Cephemcarboxylic acid esters of the general formula pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, process for the preparation of the cephem derivatives and of the pharmaceutical preparations, and use of the cephem derivatives for controlling bacterial infections.

公开(公告)号：PH31070A

公开(公告)日：1998-02-05

申请号：PH44394

申请日：1992-05-12

Applicant: HOECHST AG

Inventor： ELIZABETH DEFOSSA ,  GERD FISCHER ,  JOACHIM-HEINER JENDRALLA ,  RUDOLF LATTRELL ,  THEODOR WOLLMAN ,  DIETER ISERT

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07B57/00 ,  C07D417/12 ,  C07D501/00 ,  C07D501/12 ,  C07D501/18 ,  C07D501/32 ,  C07D501/34

Abstract: The invention relates to crystalline acid addition salts of the two diastereomers of the 1-(2,2-dimethylpropionyloxy)ethyl ester of 3-cephem-4-carboxylic acid of the general formula II in which X represents the anion of a physiologically acceptable, mono- or polybasic, inorganic or organic acid and the group =N-OH is in the syn position, pharmaceutical preparations active against bacterial infections and which contain such cephem derivatives, a process for the preparation of the cephem derivatives, and the use of the cephem derivatives for the control of bacterial infections.

公开(公告)号：LV10279B

公开(公告)日：1995-08-20

申请号：LV920702

申请日：1992-12-23

Applicant: HOECHST AG

Inventor： ELISABETH DEFOSSA ,  GERD FISCHER ,  JOACHIM-HEINER JENDRALLA ,  RUDOLF LATTRELL ,  THEODOR WOLLMANN ,  DIETER ISERT

IPC: A61K31/545 ,  C07D501/34

Abstract: The innovation relates to 3-Cefem-4-carbonacid-1-(2,2-dimethylpropioniloxsy) ethylester both diastereomer crystal salines having general formula (II) where X stands for physiologically harmless monobasic or multi-basic inorganic or organic acid anion, but group =N- OH is in sin-state. Crystal salines of both diastereomers are characteristic in that the formula (II) C- atom marked with a star has (1S)-configuration. These compositions are effective against bacterial infections. The innovation includes acquisition of pharmaceutical compositions containing these cephem derivations as well as their application in fighting bacterial infections.

公开(公告)号：ZA926710B

公开(公告)日：1993-04-28

申请号：ZA926710

申请日：1992-09-04

Applicant: HOECHST AG

Inventor： FISCHER GERD ,  GERD FISCHER ,  ISERT DIETER ,  DIETER ISERT ,  GERLACH UWE ,  UWE GERLACH ,  DEFOSSA ELISABETH ,  ELISABETH DEFOSSA ,  LATTRELL RUDOLF ,  RUDOLF LATTRELL ,  KRASS NORBERT ,  NORBERT KRASS ,  STACHE ULRICH ,  ULRICH STACHE ,  HOERLEIN ROLF ,  ROLF HOERLEIN ,  WOLLMANN THEODOR ,  THEODOR WOLLMANN

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/06 ,  C07D501/34 ,  C07D501/56 ,  C07D ,  A61K

Abstract: Enterally absorbable diastereomers of (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(m ethoxymethyl)-3-cephem-4-carboxylic acid 1-(isopropoxycarbonyloxy)ethyl ester of the formula I and its physiologically acceptable salts and also diastereomerically pure salts of the compounds of the general formula II where HX represents a mono- or polybasic acid and where X represents an inorganic or organic physiologically acceptable anion, and a process for the preparation of these compounds of the formula I or II are described, which is characterised in that on mixing together one equivalent of a solution of the diastereomer mixture of the formula III with 0.2 - 2 equivalents of a solution of the acid component HY the more poorly soluble diastereomer of the general formula IV is first precipitated and separated off by filtration, then the more readily soluble diastereomer of the general formula IV is precipitated from the filtration solution, it being possible in the subsequent subsidiary steps for the acid components HY to be identical or different and any desired sequence of the addition of different acid components HY to be used, and the salts obtained are optionally further purified by crystallisation.