公开(公告)号：JPH1067772A

公开(公告)日：1998-03-10

申请号：JP13798497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOEGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound opened by cyclic adenosine- phosphoric acid (CAMP), exhibiting strong and specific blocking action in K channel different from K (ATP) channel and useful as an agent, etc., for treating tumor of stomach and intestinal canal. SOLUTION: This chroman is represented by formula I R(1) or R(2) are each independently H, a 1-6C alkyl, etc.; R(3) is a group of R(9)-Cn H2n [NR(11)] [R(9) is H or a 3-8C cycloalkyl; (n) is an integer of 0-10; R(11) and R(9) together form a 1-8C alkylene]; R(4) is a group of R(12)-Cr H2r [R(12) is H, a 3-8C cycloalkyl, etc.; (r) is an integer of 1-20]; R(5) to R(8) are each independently H, F, Cl, Br, I, a 1-4C alkyl, etc.} or its physiologically permissible salt, e.g. a compound of formula II. The compound of the formula is obtained by alkylation, etc., of sulfonamide by a chroman derivative having alkylation action.

公开(公告)号：CZ149497A3

公开(公告)日：1997-12-17

申请号：CZ149497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

公开(公告)号：DE19639462A1

公开(公告)日：1998-04-02

申请号：DE19639462

申请日：1996-09-26

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOEGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/353 ,  C07D311/68 ,  C07D311/70 ,  A61K31/35 ,  C07D405/12 ,  C07D409/12

Abstract: Chromans of formula (I) and their salts are new: where R(1), R(2) = H, fluoroalkyl, 1-6C alkyl, optionally substituted phenyl; or R(1) and R(2) = 2-10C alkyl chain; R(3) = substituted alkylsulphonamide; R(4) = substituted 1-20C alkyl; R(5), R(6), R(7), R(8) = H, halogen, 1-4C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, amido, ester, substituted alkyl-sulphone, -ketone, -amine, -ether, or -amide, optionally substituted phenyl; where R(6) OCF3 or OC2F5. Also claimed are compounds of formula (Ia): where R(A) = H, OH, O(CO)-(1-4C alkyl), O(SO2)-(1-4C alkyl); R(B) = H; or R(A) and R(B) = a bond; R(1) -R(4) = as for (I);and R(C) = CN, 1-6C acyl, F, Cl, Br, I, NO2, 1-6C alkyl.

公开(公告)号：CZ9701494A3

公开(公告)日：1997-12-17

申请号：CZ149497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

CPC classification number: A61K31/353 ,  C07D311/68 ,  C07D311/70

公开(公告)号：DE19619614A1

公开(公告)日：1997-11-20

申请号：DE19619614

申请日：1996-05-15

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOEGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/353 ,  A61P9/00 ,  C07D311/68 ,  C07D311/70 ,  A61K31/35 ,  C07D311/22

Abstract: Chromans of formula (I) and their salts are new: where R(1), R(2) = H, fluoroalkyl, 1-6C alkyl, optionally substituted phenyl; or R(1) and R(2) = 2-10C alkyl chain; R(3) = substituted alkylsulphonamide; R(4) = substituted 1-20C alkyl; R(5), R(6), R(7), R(8) = H, halogen, 1-4C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, amido, ester, substituted alkyl-sulphone, -ketone, -amine, -ether, or -amide, optionally substituted phenyl; where R(6) OCF3 or OC2F5. Also claimed are compounds of formula (Ia): where R(A) = H, OH, O(CO)-(1-4C alkyl), O(SO2)-(1-4C alkyl); R(B) = H; or R(A) and R(B) = a bond; R(1) -R(4) = as for (I);and R(C) = CN, 1-6C acyl, F, Cl, Br, I, NO2, 1-6C alkyl.