公开(公告)号：JPH1067772A

公开(公告)日：1998-03-10

申请号：JP13798497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOEGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound opened by cyclic adenosine- phosphoric acid (CAMP), exhibiting strong and specific blocking action in K channel different from K (ATP) channel and useful as an agent, etc., for treating tumor of stomach and intestinal canal. SOLUTION: This chroman is represented by formula I R(1) or R(2) are each independently H, a 1-6C alkyl, etc.; R(3) is a group of R(9)-Cn H2n [NR(11)] [R(9) is H or a 3-8C cycloalkyl; (n) is an integer of 0-10; R(11) and R(9) together form a 1-8C alkylene]; R(4) is a group of R(12)-Cr H2r [R(12) is H, a 3-8C cycloalkyl, etc.; (r) is an integer of 1-20]; R(5) to R(8) are each independently H, F, Cl, Br, I, a 1-4C alkyl, etc.} or its physiologically permissible salt, e.g. a compound of formula II. The compound of the formula is obtained by alkylation, etc., of sulfonamide by a chroman derivative having alkylation action.

公开(公告)号：CZ286825B6

公开(公告)日：2000-07-12

申请号：CZ186693

申请日：1993-09-08

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  SCHINDLER PETER DR ,  HERLING ANDREAS DR

IPC: A61K31/185 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/28 ,  A61K31/357 ,  A61K31/37 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/47 ,  A61P3/08 ,  A61P3/10 ,  C07C59/205 ,  C07C59/80 ,  C07C62/10 ,  C07C69/65 ,  C07C69/708 ,  C07C69/732 ,  C07C69/734 ,  C07C69/738 ,  C07C69/74 ,  C07C69/75 ,  C07C69/753 ,  C07C69/757 ,  C07C69/76 ,  C07C235/40 ,  C07C235/54 ,  C07C255/31 ,  C07C309/02 ,  C07C309/64 ,  C07C311/02 ,  C07D207/16 ,  C07D209/18 ,  C07D209/42 ,  C07D213/02 ,  C07D213/55 ,  C07D213/79 ,  C07D215/48 ,  C07D215/54 ,  C07D233/54 ,  C07D235/06 ,  C07D235/08 ,  C07D239/26 ,  C07D239/34 ,  C07D257/04 ,  C07D285/06 ,  C07D307/85 ,  C07D311/06 ,  C07D317/72 ,  C07D333/02 ,  C07D333/16 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D333/68 ,  C07D493/04 ,  C07D493/10 ,  C07D495/00 ,  C07D495/04 ,  C07D495/14 ,  C07D521/00

Abstract: In the present invention there are disclosed substituted cyclohexane derivatives of the general formula I, in which Re1 through Re6, X, Y and Z have specific meanings. The invented derivatives exhibit valuable pharmaceutical properties and they can be therefore used for treating diseases that are connected with increased activity of glucose-6-phosphatase system, further diseases that are connected with increased production of glucose in liver and diabetes mellitus II.

公开(公告)号：SG44819A1

公开(公告)日：1997-12-19

申请号：SG1996008250

申请日：1993-09-06

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  SCHINDLER PETER DR ,  HERLING ANDREAS DR

IPC: A61K31/185 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/28 ,  A61K31/357 ,  A61K31/37 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/47 ,  A61P3/08 ,  A61P3/10 ,  C07C59/205 ,  C07C59/80 ,  C07C62/10 ,  C07C69/65 ,  C07C69/708 ,  C07C69/732 ,  C07C69/734 ,  C07C69/738 ,  C07C69/74 ,  C07C69/75 ,  C07C69/753 ,  C07C69/757 ,  C07C69/76 ,  C07C235/40 ,  C07C235/54 ,  C07C255/31 ,  C07C309/02 ,  C07C309/64 ,  C07C311/02 ,  C07D207/16 ,  C07D209/18 ,  C07D209/42 ,  C07D213/02 ,  C07D213/55 ,  C07D213/79 ,  C07D215/48 ,  C07D215/54 ,  C07D233/54 ,  C07D235/06 ,  C07D235/08 ,  C07D239/26 ,  C07D239/34 ,  C07D257/04 ,  C07D285/06 ,  C07D307/85 ,  C07D311/06 ,  C07D317/72 ,  C07D333/02 ,  C07D333/16 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D333/68 ,  C07D493/04 ,  C07D493/10 ,  C07D495/00 ,  C07D495/04 ,  C07D495/14 ,  C07D521/00 ,  C07C

Abstract: Cyclohexane derivatives of the formula I in which the radicals R to R , X, Y and Z have the meanings indicated, and a process for the preparation of these compounds are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.

公开(公告)号：DE4404848A1

公开(公告)日：1995-08-17

申请号：DE4404848

申请日：1994-02-16

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  SCHUBERT GERRIT DR ,  BELOW PETER DR ,  HERLING ANDREAS DR ,  BURGER HANS-JOERG DR

IPC: C07D235/08 ,  A61K31/215 ,  A61K31/33 ,  A61K31/415 ,  A61K31/4166 ,  A61K31/4184 ,  A61P3/08 ,  A61P3/10 ,  C07C65/36 ,  C07C69/02 ,  C07C233/08 ,  C07C233/90 ,  C07C255/50 ,  C07C311/01 ,  C07C311/02 ,  C07C311/50 ,  C07C327/20 ,  C07C327/38 ,  C07C327/56 ,  C07C329/04 ,  C07C329/14 ,  C07C333/02 ,  C07D233/02 ,  C07D235/04 ,  C07D235/06 ,  C07D277/22 ,  C07D403/08 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10 ,  C07D491/113 ,  C07D493/10 ,  C07D257/04 ,  C07D417/14 ,  A61K31/41 ,  C07C311/16

Abstract: Cyclohexanol esters of formula (I) and their salts are new: R = CONHCOR ; CSNHR ; CONHSO2R ;etc.; or a gp. of formula (i)-(viii): V, W = N or CH; U = O or S; E = NR ; O; S; or NH;with aromatic rings in R being opt. substd. by 1 or more F, Cl, Br, I, OH,etc.; and R = 1-10C alkyl, 1-10C alkoxy, 2-10C alkenyl,etc.; or R +R form a ring of formula (xxvi): R = 1-10C alkyl, 3-8C cycloalkyl, Ph,etc.;R , R = H; OH opt. protected by usual alcohol protecting gp.; F; Cl; Br; or R ;R = H; 1-10C alkyl,R ,etc.; R = Ph, naphthyl, phenanthryl, pyridyl,etc.; R = 3-10C alkenoyl opt. substd. by R ; R -substd. 1-10C alkanoyl; or R ; X = (CH2)m; -CH=CH-; -C IDENTICAL CH-;etc.;Y = (CH2)m; O,etc.; Z = (CH2)m; S; O; 1-10C alkylthio; 1-10C alkoxy; CH=CH;etc.; or, when Y = O, -C(O)-Z-R - can be Ala, Arg, Asn,etc., or Tyr opt. protected with usual protecting gps.; m = 0-4; and n = 0-2.

公开(公告)号：DK0671392T3

公开(公告)日：2001-03-26

申请号：DK95103046

申请日：1995-03-03

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  HERLING ANDREAS DR ,  SCHUBERT GERRIT DR ,  BELOW PETER DR ,  BURGER HANS-JOERG DR

IPC: A61K31/415 ,  A61K31/4184 ,  A61K31/435 ,  C07D235/08 ,  A61P3/08 ,  A61P3/10 ,  C07D235/06 ,  C07D471/04

Abstract: Propane derivs. of formula (I), and their salts, are new: D-B-A = opt. substd. propyl, omega -hydroxy- (1-4C)alkyl, OH, OT, phenyl or phenyl(1-3C)alkyl); R = CN, COOH (opt. protected), 1-4C alkanoyl, SO3T, SO3H, SO2NR R , PO(OH)2, PO(OH)(OT), PO(OT)2 or tetrazol-5-yl; R = 1-10C alkyl(R )n, O-(1-10C)alkyl(R )n, 2-10C alkenyl(R )n, O-(3-10C)alkenyl(R )n, 2-10C alkynyl(R )n, O-(3-10C)alkynyl(R )n, S-(1-10C)alkyl(R )n, etc. (all R gps. being opt. substd.); R , R = H, T, 1-4C alkanoyl or opt. substd. phenyl; or NR R = a 4-10 membered, satd. heterocyclic ring (in which one CH2 gp. is opt. replaced by O, S or NR ); R = H, T, phenyl or benzyl; X = (CH2)m, CH=CH, C IDENTICAL C, CH2OCH2, CH2SCH2 or CH2-N(R )-CH2; Y = (CH2)m, O, S or NR ; Z = (CH2)m, S, O, S-(1-10C)alkyl, O-(1-10C)alkyl, CH=CH, CH=CF, CH=CCl, CH=CBr, CH2CO, etc.; or when Y = O, the gp. C(O)ZR may be an opt. protected amino acid residue; n = 0, 1 or 2; m = 0-4; R , R = 1-10C alkyl, 3-8C cycloalkyl, or opt. substd. Ar; T = 1-4C alkyl; Ar = phenyl, naphthyl, phenanthryl, pyridyl, thienyl, furyl, pyrimidyl, indolyl, etc.

公开(公告)号：GR3032519T3

公开(公告)日：2000-05-31

申请号：GR20000400215

申请日：2000-01-31

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  SCHUBERT GERRIT DR ,  BURGER HANS-JOERG DR ,  HERLING ANDREAS DR ,  EFENDIC SUAD PROF DR

IPC: A61K31/435 ,  A61K31/4353 ,  A61K31/52 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07D221/00 ,  C07D235/00 ,  C07D239/00 ,  C07D471/04

Abstract: Cyclohexane derivs. of formula (I), and their salts, are new. R = O-(3-5C)alkyl-R , in which the alkyl component is straight, branched or cyclic; R = phenyl (opt. 4-substd. by F, Cl or Me); and R , R = H or OH.

公开(公告)号：GR3030953T3

公开(公告)日：1999-11-30

申请号：GR990402034

申请日：1999-08-11

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  SCHINDLER PETER DR ,  UTZ ROLAND DR ,  RIPPEL ROBERT DR ,  HERLING ANDREAS DR

IPC: A61K31/185 ,  A61K31/16 ,  A61K31/19 ,  A61K31/215 ,  A61K31/235 ,  A61K31/255 ,  A61K31/36 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61K31/66 ,  A61K31/67 ,  A61K31/675 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P43/00 ,  C07C49/04 ,  C07C49/20 ,  C07C61/08 ,  C07C69/013 ,  C07C69/03 ,  C07C69/533 ,  C07C69/612 ,  C07C69/63 ,  C07C69/65 ,  C07C69/67 ,  C07C69/73 ,  C07C69/732 ,  C07C69/734 ,  C07C205/56 ,  C07C235/36 ,  C07C327/06 ,  C07C327/10 ,  C07D213/55 ,  C07D333/24 ,  C07D333/32 ,  C07F9/38 ,  C07F9/40

Abstract: Esters of cyclohexane derivatives of the formula I in which A-B, R , R , R , Y and Z have the stated meanings, for use as inhibitors of the glucose-6-phosphatase system in the liver of mammals are described. The compounds are suitable for producing pharmaceutical products.

公开(公告)号：DE59309649D1

公开(公告)日：1999-07-22

申请号：DE59309649

申请日：1993-09-06

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  SCHINDLER PETER DR ,  UTZ ROLAND DR ,  RIPPEL ROBERT DR ,  HERLING ANDREAS DR

IPC: A61K31/185 ,  A61K31/16 ,  A61K31/19 ,  A61K31/215 ,  A61K31/235 ,  A61K31/255 ,  A61K31/36 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61K31/66 ,  A61K31/67 ,  A61K31/675 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P43/00 ,  C07C49/04 ,  C07C49/20 ,  C07C61/08 ,  C07C69/013 ,  C07C69/03 ,  C07C69/533 ,  C07C69/612 ,  C07C69/63 ,  C07C69/65 ,  C07C69/67 ,  C07C69/73 ,  C07C69/732 ,  C07C69/734 ,  C07C205/56 ,  C07C235/36 ,  C07C327/06 ,  C07C327/10 ,  C07D213/55 ,  C07D333/24 ,  C07D333/32 ,  C07F9/38 ,  C07F9/40

Abstract: Esters of cyclohexane derivatives of the formula I in which A-B, R , R , R , Y and Z have the stated meanings, for use as inhibitors of the glucose-6-phosphatase system in the liver of mammals are described. The compounds are suitable for producing pharmaceutical products.

公开(公告)号：CZ284995B6

公开(公告)日：1999-04-14

申请号：CZ186793

申请日：1993-09-08

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  SCHINDLER PETER DR ,  UTZ ROLAND DR ,  RIPPEL ROBERT DR ,  HERLING ANDREAS DR

IPC: A61K31/185 ,  A61K31/16 ,  A61K31/19 ,  A61K31/215 ,  A61K31/235 ,  A61K31/255 ,  A61K31/36 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61K31/66 ,  A61K31/67 ,  A61K31/675 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P43/00 ,  C07C49/04 ,  C07C49/20 ,  C07C61/08 ,  C07C69/013 ,  C07C69/03 ,  C07C69/533 ,  C07C69/612 ,  C07C69/63 ,  C07C69/65 ,  C07C69/67 ,  C07C69/73 ,  C07C69/732 ,  C07C69/734 ,  C07C205/56 ,  C07C235/36 ,  C07C327/06 ,  C07C327/10 ,  C07D213/55 ,  C07D333/24 ,  C07D333/32 ,  C07F9/38 ,  C07F9/40

Abstract: Esters of cyclohexane derivatives of the formula I in which A-B, R , R , R , Y and Z have the stated meanings, for use as inhibitors of the glucose-6-phosphatase system in the liver of mammals are described. The compounds are suitable for producing pharmaceutical products.

公开(公告)号：DE19624155A1

公开(公告)日：1998-01-08

申请号：DE19624155

申请日：1996-06-18

Applicant: HOECHST AG

Inventor： HEMMERLE HORST DR ,  BELOW PETER DR ,  BURGER HANS-JOERG DR ,  HERLING ANDREAS DR ,  JAEHNE GERHARD DR

IPC: C07D317/60 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/335 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61K31/60 ,  A61P3/08 ,  A61P3/10 ,  C07C65/105 ,  C07C65/24 ,  C07C65/28 ,  C07C65/40 ,  C07C205/57 ,  C07C217/76 ,  C07C233/46 ,  C07C233/54 ,  C07C233/55 ,  C07C233/63 ,  C07C233/81 ,  C07C233/87 ,  C07C235/16 ,  C07C235/24 ,  C07C235/38 ,  C07C235/56 ,  C07C235/64 ,  C07C237/40 ,  C07C255/56 ,  C07C255/57 ,  C07C275/42 ,  C07C311/21 ,  C07C323/50 ,  C07D213/55 ,  C07D213/81 ,  C07D213/82 ,  C07D241/44 ,  C07D307/54 ,  C07D307/66 ,  C07D307/68 ,  C07D317/50 ,  C07D317/68 ,  C07D333/24 ,  C07D333/28 ,  C07D333/36 ,  C07D333/38 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07C65/21 ,  A61K31/16 ,  C07C233/53