公开(公告)号：JPH1067772A

公开(公告)日：1998-03-10

申请号：JP13798497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOEGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

Abstract: PROBLEM TO BE SOLVED: To obtain the subject new compound opened by cyclic adenosine- phosphoric acid (CAMP), exhibiting strong and specific blocking action in K channel different from K (ATP) channel and useful as an agent, etc., for treating tumor of stomach and intestinal canal. SOLUTION: This chroman is represented by formula I R(1) or R(2) are each independently H, a 1-6C alkyl, etc.; R(3) is a group of R(9)-Cn H2n [NR(11)] [R(9) is H or a 3-8C cycloalkyl; (n) is an integer of 0-10; R(11) and R(9) together form a 1-8C alkylene]; R(4) is a group of R(12)-Cr H2r [R(12) is H, a 3-8C cycloalkyl, etc.; (r) is an integer of 1-20]; R(5) to R(8) are each independently H, F, Cl, Br, I, a 1-4C alkyl, etc.} or its physiologically permissible salt, e.g. a compound of formula II. The compound of the formula is obtained by alkylation, etc., of sulfonamide by a chroman derivative having alkylation action.

公开(公告)号：CZ149497A3

公开(公告)日：1997-12-17

申请号：CZ149497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

公开(公告)号：DE3608726A1

公开(公告)日：1987-09-17

申请号：DE3608726

申请日：1986-03-15

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  HROPOT MAX DR ,  LANG HANS JOCHEN DR ,  GREGER RAINER PROF DR

IPC: A61K31/195 ,  A61K31/245 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61K31/55 ,  A61P1/12 ,  C07C67/00 ,  C07C227/00 ,  C07C229/56 ,  C07D207/32 ,  C07D207/327 ,  A61K31/24

Abstract: There is described the use of amino-substituted benzoic acid derivatives of the formula I … … in which:… R and R represent hydrogen, (cyclo)alkyl, unsubstituted or substituted phenyl or naphthyl, or… R and R together represent a chain -(CH2)m- where m = 3 to 6, or together represent a chain -(CH=CH)n- where n is 2 or 3; R represents hydrogen, halogen or alkyl; R represents hydrogen or NO2; R represents hydrogen or a radical which can be eliminated under physiological conditions;… for preparing a medicament against diarrhoea.

公开(公告)号：DE3682136D1

公开(公告)日：1991-11-28

申请号：DE3682136

申请日：1986-07-22

Applicant: HOECHST AG

Inventor： GREGER RAINER PROF DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  LANG HANS-JOCHEN DR ,  HROPOT MAX DR

IPC: A61K31/195 ,  A61K31/34 ,  C07C205/57 ,  C07C229/56 ,  C07D307/52

Abstract: N-Aralkyl-5-nitroanthranilic acid derivs. of formula (I) and their salts are new. R = H or 1-4C alkyl; X = (CH2)n, opt. substd. by up to 2n 1-2C alkyl gps. and/or by an additional Ar gp.; m = 1-4; Ar = aromatic or heteroaromatic gp., opt. substd. by 1-3 1-2C alkyl, 1-2C alkoxy, F, Cl, Br, I or CF3 gps. Pref. R = H; X = (CH2)2 or (CH2)3; Ar = Ph.

公开(公告)号：AT68785T

公开(公告)日：1991-11-15

申请号：AT86110027

申请日：1986-07-22

Applicant: HOECHST AG

Inventor： GREGER RAINER PROF DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  LANG HANS-JOCHEN DR ,  HROPOT MAX DR

IPC: A61K31/195 ,  A61K31/34 ,  C07C205/57 ,  C07C229/56 ,  C07D307/52

公开(公告)号：DE3608725A1

公开(公告)日：1987-09-17

申请号：DE3608725

申请日：1986-03-15

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  HROPOT MAX DR ,  LANG HANS-JOCHEN DR ,  GREGER RAINER PROF DR

IPC: A61K31/195 ,  A61K31/22 ,  A61P1/12 ,  C07C67/00 ,  C07C227/00 ,  C07C227/08 ,  C07C227/16 ,  C07C227/22 ,  C07C229/18 ,  C07C229/34 ,  C07D205/08 ,  C07D207/26 ,  C07D211/74 ,  C07D227/04 ,  C07C101/34

Abstract: A process for preparing a compound of the formula I … … in which:… R , R , R (identical or different) represent H, alkyl having 1-2 C-atoms and F, Cl, Br or I;… R represents H or alkyl having 1-4 C-atoms,… n represents the numbers 2-5 and… R represents a radical which can be removed under physiological conditions or hydrogen, and their physiologically tolerable salts. … They are effective medicines against diarrhoea.

公开(公告)号：DE3528048A1

公开(公告)日：1987-02-05

申请号：DE3528048

申请日：1985-08-05

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH C DR ,  GREGER RAINER PROF DR ,  HROPOT MAX DR ,  LANG HANS-JOCHEN DR

IPC: C07D307/52 ,  C07C101/52 ,  A61K31/19 ,  A61K31/34 ,  A61K31/395

Abstract: Compounds I where R is equal to hydrogen or alkyl, X is equal to alkylene and Ar is equal to aromatic, show an excellent detumescent action on cerebral oedemas, as well as intestinal action.

公开(公告)号：DE19639462A1

公开(公告)日：1998-04-02

申请号：DE19639462

申请日：1996-09-26

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOEGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/353 ,  C07D311/68 ,  C07D311/70 ,  A61K31/35 ,  C07D405/12 ,  C07D409/12

Abstract: Chromans of formula (I) and their salts are new: where R(1), R(2) = H, fluoroalkyl, 1-6C alkyl, optionally substituted phenyl; or R(1) and R(2) = 2-10C alkyl chain; R(3) = substituted alkylsulphonamide; R(4) = substituted 1-20C alkyl; R(5), R(6), R(7), R(8) = H, halogen, 1-4C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, amido, ester, substituted alkyl-sulphone, -ketone, -amine, -ether, or -amide, optionally substituted phenyl; where R(6) OCF3 or OC2F5. Also claimed are compounds of formula (Ia): where R(A) = H, OH, O(CO)-(1-4C alkyl), O(SO2)-(1-4C alkyl); R(B) = H; or R(A) and R(B) = a bond; R(1) -R(4) = as for (I);and R(C) = CN, 1-6C acyl, F, Cl, Br, I, NO2, 1-6C alkyl.

公开(公告)号：CZ9701494A3

公开(公告)日：1997-12-17

申请号：CZ149497

申请日：1997-05-14

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/353 ,  A61K31/44 ,  A61K31/443 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/06 ,  C07D311/68 ,  C07D311/70 ,  C07D311/72 ,  C07D311/96 ,  C07D405/12

CPC classification number: A61K31/353 ,  C07D311/68 ,  C07D311/70

公开(公告)号：DE19619614A1

公开(公告)日：1997-11-20

申请号：DE19619614

申请日：1996-05-15

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  GERLACH UWE DR ,  BRENDEL JOACHIM DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  GOEGELEIN HEINZ DR ,  HROPOT MAX DR ,  BOHN HELMUT DR ,  HERLING ANDREAS DR ,  BUSCH ANDREAS PROF DR ,  GREGER RAINER PROF DR

IPC: A61K31/353 ,  A61P9/00 ,  C07D311/68 ,  C07D311/70 ,  A61K31/35 ,  C07D311/22

Abstract: Chromans of formula (I) and their salts are new: where R(1), R(2) = H, fluoroalkyl, 1-6C alkyl, optionally substituted phenyl; or R(1) and R(2) = 2-10C alkyl chain; R(3) = substituted alkylsulphonamide; R(4) = substituted 1-20C alkyl; R(5), R(6), R(7), R(8) = H, halogen, 1-4C alkyl, 3-8C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, amido, ester, substituted alkyl-sulphone, -ketone, -amine, -ether, or -amide, optionally substituted phenyl; where R(6) OCF3 or OC2F5. Also claimed are compounds of formula (Ia): where R(A) = H, OH, O(CO)-(1-4C alkyl), O(SO2)-(1-4C alkyl); R(B) = H; or R(A) and R(B) = a bond; R(1) -R(4) = as for (I);and R(C) = CN, 1-6C acyl, F, Cl, Br, I, NO2, 1-6C alkyl.