公开(公告)号：PT89537B

公开(公告)日：1994-05-31

申请号：PT8953789

申请日：1989-01-26

Applicant: HOECHST AG

Inventor： HENNING RAINER ,  HOCK FRANZ ,  STECHL JENS ,  USINGER PATRICIA ,  URBACH HANSJORG ,  RUGER WOLFGANG

IPC: C07D209/00 ,  C07K5/06 ,  A61K37/64

公开(公告)号：PH27210A

公开(公告)日：1993-05-04

申请号：PH35073

申请日：1987-03-25

Applicant: HOECHST AG

Inventor： HOCK FRANZ ,  URBACH HANSJORG ,  HENNING RAINER ,  LERCH ULRICH ,  NICKEL WOLF-ULRICH ,  RUGER WOLFGANG

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  A61K37/02 ,  A61K37/64

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：AU630386B2

公开(公告)日：1992-10-29

申请号：AU4600589

申请日：1989-12-08

Applicant: HOECHST AG

Inventor： RUGER WOLFGANG ,  URBACH HANSJORG ,  RUPPERT DIETER ,  SCHOLKENS BERNWARD

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  A61K37/02 ,  A61K37/64

Abstract: The present invention relates to compounds of the formula I in which A and B are, independently of one another, an amino acid, X either can be absent or is -O-, -S-, -CF2-, -CO- or -CHR , p and q are, independently of one another, 0, 1, 2, 3 or 4, and R to R are defined in the description, and the salts thereof. The invention also relates to a process for preparing the compounds of the formula I and to their use as medicines.

公开(公告)号：NZ231435A

公开(公告)日：1992-01-29

申请号：NZ23143589

申请日：1989-11-17

Applicant: HOECHST AG

Inventor： NICKEL WOLF-ULRICH ,  RUGER WOLFGANG ,  URBACH HANSJORG ,  HOCK FRANZ

IPC: A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/28 ,  C07D207/16 ,  C07D209/52 ,  C07K5/06 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D209/26 ,  C07D207/09 ,  A61K31/405

Abstract: The present invention relates to compounds of the formula I (I) in which R1 to R4 are defined in the description, processes for their preparation, their use for the treatment and prophylaxis of cognitive dysfunctions and pharmaceuticals containing them and processes for their preparation.

公开(公告)号：AU617118B2

公开(公告)日：1991-11-21

申请号：AU2227988

申请日：1988-09-15

Applicant: HOECHST AG

Inventor： RUGER WOLFGANG ,  URBACH HANSJORG ,  BECKER REINHARD ,  HOCK FRANZ

IPC: C07D317/34 ,  A61K38/00 ,  A61K38/55 ,  A61P25/28 ,  A61P29/00 ,  C07D317/36 ,  C07D317/40 ,  C07D405/12 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  A61K31/40 ,  A61K31/47 ,  A61K31/475

Abstract: The esters have the formula I … … in which n is 1 or 2, R, R , R and R are hydrogen or a defined radical, R together with R and the atoms carrying them form a heterocyclic ring system.

公开(公告)号：AU615252B2

公开(公告)日：1991-09-26

申请号：AU2884489

申请日：1989-01-26

Applicant: HOECHST AG

Inventor： RUGER WOLFGANG ,  HOCK FRANZ ,  URBACH HANSJORG ,  HENNING RAINER ,  STECHL JENS ,  USINGER PATRICIA

IPC: C12N9/99 ,  A61K31/405 ,  A61K31/47 ,  A61K31/55 ,  A61K38/00 ,  A61K38/55 ,  A61K45/06 ,  A61P25/18 ,  A61P25/20 ,  C07D209/52 ,  C07D223/10 ,  C07D223/16 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  A61K31/40 ,  C07D209/42

Abstract: The invention relates to the use of angiotensin converting enzyme inhibitors as pharmaceuticals with a psychotropic, in particular anxiolytic, effect, to agents containing these and to the use thereof for the treatment or prophylaxis of disorders of the central nervous system, especially of anxiety states. … The invention furthermore relates to compounds of the formula … … in which R is hydrogen or ethyl and R is n-octyl, to processes for the preparation thereof, to agents containing these, and to the use thereof as pharmaceuticals.

公开(公告)号：CA2005422A1

公开(公告)日：1990-06-14

申请号：CA2005422

申请日：1989-12-13

Applicant: HOECHST AG

Inventor： RUGER WOLFGANG ,  URBACH HANSJORG ,  RUPPERT DIETER ,  SCHOLKENS BERNWARD

IPC: A61K31/16 ,  A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07C291/02 ,  C07D213/81 ,  C07D233/64 ,  C07D295/18 ,  C07D333/24 ,  C07D521/00 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81 ,  C07K5/04 ,  A61K38/04

Abstract: of the disclosures: Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof The present invention relates to compounds of the general formula I (I) in which A denotes a radical from the group comprising S, SO, SO2, O, CO, CS or a direct bond, B denotes the radical of an amino acid and D denotes a CH2 group or a radical -NR7-, where R7 can be hydrogen or a (C1-C4)alkyl radical; and in which R1 to R4 are defined as indicated in the description, to a process for the preparation thereof, to agents containing these, and to the use thereof.

公开(公告)号：PT89501A

公开(公告)日：1989-10-04

申请号：PT8950189

申请日：1989-01-10

Applicant: HOECHST AG

Inventor： HOCK FRANZ ,  URBACH HANSJORG ,  RUGER WOLFGANG ,  BECKER REINHARD

IPC: A61K38/55 ,  A61K38/00 ,  A61P9/12 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  C07K5/00 ,  A61K37/02

Abstract: The invention relates to amino acid esters of the formula (I) in which n=1 or 2, R, R1, R2 and R3 denote hydrogen or a defined radical, R4 together with R5 and the atoms carrying them form a heterocyclic ring system, processes for their preparation, agents containing them and their use.

公开(公告)号：NO178546C

公开(公告)日：1996-04-17

申请号：NO871282

申请日：1987-03-26

Applicant: HOECHST AG

Inventor： HOCK FRANZ ,  SCHOLTHOLT JOSEF ,  URBACH HANSJORG ,  HENNING RAINER ,  LERCH ULRICH ,  NICKEL WOLF-ULRICH ,  RUGER WOLFGANG

IPC: C07K14/81 ,  A61K38/00 ,  A61P9/12 ,  A61P25/28 ,  C07C235/02 ,  C07K1/06 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

Abstract: The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the treatment and prophylaxis of cognitive malfunctions.

公开(公告)号：PT87456B

公开(公告)日：1992-09-30

申请号：PT8745688

申请日：1988-05-11

Applicant: HOECHST AG

Inventor： URBACH HANSJORG ,  RUGER WOLFGANG ,  KAISER JOACHIM

IPC: A61K31/135 ,  A61K31/165 ,  A61K31/19 ,  A61K31/235 ,  A61K31/275 ,  A61K31/395 ,  A61K31/445 ,  C07D295/08 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/495 ,  A61P3/00 ,  A61P3/14 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07C67/00 ,  C07C313/00 ,  C07C323/25 ,  C07C323/36 ,  C07C323/62 ,  C07C323/65 ,  C07C323/66 ,  C07C323/67 ,  C07D207/08 ,  C07D211/56 ,  C07D295/092 ,  C07D211/18 ,  C07D211/58 ,  C07D243/08 ,  A61K31/055

Abstract: Compounds I are described (I) with R1 equal to (cyclo)alk(en)yl or R2/R3 equal to phenyl or phenylalkyl, A equal to m equal to 2-4, and n equal to 1-4. Compounds I and their salts are calcium antagonists.