公开(公告)号：US3660569A

公开(公告)日：1972-05-02

申请号：US3660569D

申请日：1965-11-30

Applicant: HOECHST AG

Inventor： SCHACHT ULRICH ,  TSCHESCHE RUDOLF ,  DUPHORN INGOLF

IPC: C07G11/00 ,  C12P1/06 ,  A61K21/00

CPC classification number: C07G11/00 ,  C12P1/06 ,  C12R1/465

Abstract: THREE COMPONENTS OF MOENOMYCIN HAVING MOLECULAR WEIGHTS OF 68,000 TO 70,000 PRACTICALLY INDENTICAL INFRARED SPECTRA AND ELEMENTARY ANALYSES, AND A METHOD FOR SEPARATING SAID COMPONENTS FROM PURE MOENOMYCIN.

公开(公告)号：US3432597A

公开(公告)日：1969-03-11

申请号：US3432597D

申请日：1966-08-18

Applicant: HOECHST AG

Inventor： SCHACHT ULRICH

IPC: A61K20060101 ,  C07G20060101 ,  C07G11/00 ,  A61K21/00

CPC classification number: A61K31/70

公开(公告)号：CA1334196C

公开(公告)日：1995-01-31

申请号：CA518739

申请日：1986-09-22

Applicant: HOECHST AG

Inventor： SIEGEL HERBERT ,  KAMPE KLAUS-DIETER ,  ALPERMANN HANS G ,  GERHARDS HERMANN J ,  USINGER PATRICIA ,  SCHACHT ULRICH ,  LEVEN MARGRET ,  RAETHER WOLFGANG ,  DITTMAR WALTER ,  SACHSE BURKHARD

IPC: A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00 ,  C07D233/56 ,  C07D405/06

Abstract: Arylmethylazoles of the formula I in which Aryl is (substituted) phenyl or naphthyl; Z is CH or N; R1 and Q are H or alkyl; R2 is H, alk(en)yl or alkynyl; R3 and R4 are H, alkyl or other hydrocarbons; or R3 and R4 together are a -(CH2)2-11 chain or a bridged -(CH2)4-5 chain, and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity. The compounds of the Formula I are obtained, inter alia, from arylmethylazoles II II which are reacted with a strong base and then with a carbonyl compound III 0=CR3R4; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R2Hal. If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.

公开(公告)号：FI87774C

公开(公告)日：1993-02-25

申请号：FI863795

申请日：1986-09-19

Applicant: HOECHST AG

Inventor： SIEGEL HERBERT ,  KAMPE KLAUS-DIETER ,  ALPERMANN HANS GEORG ,  GERHARDS HERMANN JOSEF ,  USINGER PATRICIA ,  SCHACHT ULRICH ,  LEVEN MARGRET ,  RAETHER WOLFGANG ,  DITTMAR WALTER ,  SACHSE BURKHARD

IPC: A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00

公开(公告)号：DE3681544D1

公开(公告)日：1991-10-24

申请号：DE3681544

申请日：1986-09-12

Applicant: HOECHST AG

Inventor： SIEGEL HERBERT ,  KAMPE KLAUS-DIETER ,  ALPERMANN HANS GEORG ,  GERHARDS HERMANN JOSEF ,  USINGER PATRICIA ,  SCHACHT ULRICH ,  LEVEN MARGRET ,  RAETHER WOLFGANG ,  DITTMAR WALTER ,  SACHSE BURKHARD

IPC: A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00

Abstract: Imidazole or 1,2,4-triazole derivs. of formula (I) and their acid-addn. salts and isomers are new. Ar = (a) phenyl substd. by W, X and Y, or (b) 1- or 2-naphthyl substd. by V and/or U; X = H, 1-4C alkyl, phenyl, F, Cl, Br, OH, 1-4C alkoxy, OAr, 1-4C alkylthio, NR5R'5, CF3 or OCH2Ar2; Ar1 = phenyl substd. by U; Ar2 = phenyl opt. substd. by 1 or 2 of F, Cl, OMe, OEt, and 1-3C alkyl; R5 and R'5 = 1-4C alkyl, or NR5R'5 = pyrrolidino, piperidino or morpholino; Y = H, 1-4C alkyl, F, Cl, Br, 1-4C alkoxy or 1-4C alkylthio; or X+Y = (CH2)x, OCH2CH2 or OCH2O in the 2,3 or 3,4 posn.; W = H, Me or OMe; V = 1-4C alkyl, phenyl, F, Cl, Br, OH, 1-4C alkoxy, 1-4C alkylthio, NR5R'5, benzyloxy or CF3; U = Me, F, Cl or OMe; Z = CH or N; R1 and Q = H or 1-4C alkyl; R2 = H, 1-4C alkyl, 3-5C alkenyl or 3-5C alkynyl; R3 and R4 = H or a 1-12C alkyl or other hydrocarbyl gp. opt. substd. or R3+R4 = (a) 2-11C linear alkylene or alkenylene and/or fused with 1 or 2 benzene rings opt. substd. or (b) 4-5C alkylene which is opt. substd. by 1-4C alkyl, OMe, CH2OMe or phenyl and is bridged by one or more 1-5C bridging gps. which may themselves be bridged, where one bridging gp. may contain a C=C bond and the bridged alkylene gp. may be fused with 1 or 2 benzene rings opt. substd.

公开(公告)号：AU7411291A

公开(公告)日：1991-10-10

申请号：AU7411291

申请日：1991-04-04

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  SCHACHT ULRICH ,  KESSELER KURT ,  GRANZER ERNOLD

IPC: A61K31/35 ,  A61K31/352 ,  A61P3/06 ,  A61P9/10 ,  A61P31/00 ,  C07D211/20 ,  C07D311/30

Abstract: Substituted 3-thia- and 3-oxa-alkylflavones of formula I I wherein R, R1, R2, R3, R4+L, X, m and n have the indicated meanings, a process for the preparation of these compounds and their use as medicaments and pharmaceutical preparations are described. In addition, new intermediates for the preparation of the compounds of formula I are described.

公开(公告)号：FI911616A

公开(公告)日：1991-10-07

申请号：FI911616

申请日：1991-04-04

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  SCHACHT ULRICH ,  KESSELER KURT ,  GRANZER ERNOLD

IPC: A61K31/35 ,  A61K31/352 ,  A61P3/06 ,  A61P9/10 ,  A61P31/00 ,  C07D211/20 ,  C07D311/30 ,  C07D

Abstract: Substituted 3-thia- and 3-oxa-alkylflavones of formula I I wherein R, R1, R2, R3, R4+L, X, m and n have the indicated meanings, a process for the preparation of these compounds and their use as medicaments and pharmaceutical preparations are described. In addition, new intermediates for the preparation of the compounds of formula I are described.

公开(公告)号：CA2039909A1

公开(公告)日：1991-10-07

申请号：CA2039909

申请日：1991-04-05

Applicant: HOECHST AG

Inventor： BECK GERHARD ,  SCHACHT ULRICH ,  KESSELER KURT ,  GRANZER ERNOLD

IPC: A61K31/35 ,  A61K31/352 ,  A61P3/06 ,  A61P9/10 ,  A61P31/00 ,  C07D211/20 ,  C07D311/30 ,  C07D311/22

Abstract: Substituted 3-thia- and 3-oxa-alkylflavones of formula I (see formula I) wherein R, R1, R2, R3, R4, X, m and n have the indicated meanings, a process for the preparation of these com- pounds and their use as medicaments and pharmaceutical preparations are described. In addition, new inter- mediates for the preparation of the compounds of formula I are described.

公开(公告)号：PH24050A

公开(公告)日：1990-03-05

申请号：PH34277

申请日：1986-09-22

Applicant: HOECHST AG

Inventor： SIEGEL HERBERT ,  GERHARDS HERMANN JOSEF ,  SCHACHT ULRICH ,  DITTMAR WALTER ,  KAMPE KLAUS-DIETER ,  USINGER PATRICIA ,  LEVEN MARGARET ,  RAETHER WOLFGANG ,  SACHSE BURKHARD ,  ALPERMANN HANS GEORG

IPC: A61K31/41 ,  A61K31/415 ,  C07D233/60 ,  C07D233/64 ,  C07D249/08 ,  C07D521/00

Abstract: Arylmethylazoles of the formula I I in which Aryl is (substituted) phenyl or naphthyl; Z is CH or N; R1 and Q are H or alkyl; R2 is H, alk(en)yl or alkynyl; R3 and R4 are H, alkyl or other hydrocarbons; or R3 and R4 together are a -(CH2)2-11 chain or a bridged -(CH2)4-5 chain, and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity. They are obtained, inter alia, from arylmethylazoles II II which are reacted with a strong base and then with a carbonyl compound III O=CR3R4; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R2Hal. If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.

公开(公告)号：EG13777A

公开(公告)日：1982-03-31

申请号：EG34378

申请日：1978-05-29

Applicant: HOECHST AG

Inventor： SCHMITT KARL ,  SCHACHT ULRICH

IPC: C07D217/18 ,  A61K31/47 ,  A61K31/472 ,  A61P25/24 ,  A61P25/26 ,  C07D217/04

Abstract: 4-Phenyl-8-amino-tetrahydroisoquinolines of the formula in which R1 stands for bromine and R2 stands for hydrogen or both R1 and R2 represent chlorine, and their salts with physiologically tolerated acids, pharmaceutical preparations prepared therefrom, process for the manufacture of these preparations and their use for the treatment of depressive conditions.