公开(公告)号：CZ282384B6

公开(公告)日：1997-07-16

申请号：CS490689

申请日：1989-08-21

Applicant: HOECHST AG

Inventor： HENKE STEPHAN DR ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  STECHL JENS DR ,  SCHOLKENS BERNWARD DR ,  FEHLHABER HANS-WOLFRAM DR

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：DE3931554A1

公开(公告)日：1991-04-04

申请号：DE3931554

申请日：1989-09-22

Applicant: HOECHST AG

Inventor： KAMPE KLAUS-DIETER DR ,  GERHARDS HERMANN JOSEF DR ,  STECHL JENS DR ,  USINGER PATRICIA DR

IPC: C07D233/60 ,  A61K31/415 ,  A61P25/24 ,  A61P25/26 ,  C07D233/64 ,  C07D521/00

公开(公告)号：DE3901291A1

公开(公告)日：1989-08-03

申请号：DE3901291

申请日：1989-01-18

Applicant: HOECHST AG

Inventor： RUEGER WOLFGANG DR ,  URBACH HANSJOERG DR ,  HENNING RAINER DR ,  STECHL JENS DR ,  USINGER PATRICIA DR ,  HOCK FRANZ DR

IPC: A61K38/00 ,  C07K5/02

Abstract: The invention relates to the use of angiotensin converting enzyme inhibitors as pharmaceuticals with psychotropic, in particular anxiolytic, action, compositions containing these and to the use thereof for the treatment or prophylaxis of central nervous system disorders, in particular of anxiety states. The invention furthermore relates to compounds of the formula in which R is hydrogen or ethyl and R is n-octyl, to processes for their preparation, to compositions containing these and to the use thereof as pharmaceuticals.

公开(公告)号：CZ8904906A3

公开(公告)日：1997-03-12

申请号：CS490689

申请日：1989-08-21

Applicant: HOECHST AG

Inventor： HENKE STEPHAN DR ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  STECHL JENS DR ,  SCHOLKENS BERNWARD DR ,  FEHLHABER HANS-WOLFRAM DR

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18

CPC classification number: C07K7/18 ,  A61K38/00

公开(公告)号：DE3938751A1

公开(公告)日：1990-05-31

申请号：DE3938751

申请日：1989-11-21

Applicant: HOECHST AG

Inventor： HENKE STEPHAN DR ,  ANAGNOSTOPULOS HINISTO ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  FEHLHABER HANS-WOLFRAM DR ,  STECHL JENS DR ,  SCHOELKENS BERWARD PROF DR

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18

Abstract: Peptides of formula(I) and' their physiologically tolerable salts are new, where A = H; 1-8C alkyl, alkanoyl, alkoxycarbonyl or alkylsulphonyl 6-12C aryloxy, 3-9C heteroaryl or 3-9C heteroaryloxy, A can also be R1-N(R2)-C(R3)H-CO-; R1 = any of the gps. (A') already defined for A; R2 = H or Me; R3 = H or 1-6C alkyl (opt. substd. once by amino (opt. substd.), OH, COOH, CONH2, guanidino (opt. substd.) ureido, SH, CH35, phenyl (itself opt. substd. at 4 position by Cl, F, NO2, MeO or OH), phthalimido, 4-imidazolyl, 3-indolyl, 2- or 3-thienyl, 2- or 3-pyridyl, or cyclohexyl); substd. amino is NHA' and substd. guanidino is NH.C(NH).NHA; B = L- or D-basic amino acid, opt. substd. in the side-chain; C = G'-G'-Gly or G'-NH-(CH2)n-CO; each G' = -N(R4)-C(R5)H-CO-; R4 and R5 together complete a 2-15C mono,-bi- or tri-cyclic heterocyclic system; n = 2-8; E = residue of an aromatic amino acid; F = residue of a neutral, acidic or basic, aliphatic or aromatic amino acid (opt. substd. in the side-chain) or a bond; (D)-Tic is the gp. (i). G is G' or a bond; F' = F, NH(CH2)n or (provided G is not a bond) a bond; I = OH, NH2 or NHEt; K = NH(CH2)xCO or a bond; x = 1-4; M is as F.

公开(公告)号：CZ490689A3

公开(公告)日：1997-03-12

申请号：CS490689

申请日：1989-08-21

Applicant: HOECHST AG

Inventor： HENKE STEPHAN DR ,  ANAGNOSTOPULOS HIRISTO ,  BREIPOHL GERHARD DR ,  KNOLLE JOCHEN DR ,  STECHL JENS DR ,  SCHOLKENS BERNWARD DR ,  FEHLHABER HANS-WOLFRAM DR

IPC: A61K38/17 ,  A61K38/00 ,  A61K38/08 ,  A61P9/00 ,  A61P9/02 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07K1/06 ,  C07K7/06 ,  C07K7/08 ,  C07K7/18

Abstract: Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5 and K is a radical -NH(CH2)-1-4-CO- or is a direct bond, have bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are promoted, induced or sustained by bradykinin and bradykinin- related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

公开(公告)号：DE3907600A1

公开(公告)日：1990-09-13

申请号：DE3907600

申请日：1989-03-09

Applicant: HOECHST AG

Inventor： KOTTMANN HARIOLF DR ,  KIRSCH REINHARD DR ,  STECHL JENS DR

IPC: A61K31/41 ,  A61K31/415

Abstract: 1,1,1-Trisubstituted 2-(1-azolyl)ethane derivatives of the formula I in which the symbols R , R , X and A have the stated meanings, are suitable for the prophylaxis and treatment of convulsions, anxiety states and/or epilepsy.

公开(公告)号：DE3902031A1

公开(公告)日：1990-07-26

申请号：DE3902031

申请日：1989-01-25

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD DR ,  KOTTMANN HARIOLF DR ,  SCHAPER WOLFGANG DR ,  STECHL JENS DR

IPC: C07D233/60 ,  C07D233/68 ,  C07D249/08 ,  C07D521/00

Abstract: Substituted azolylmethylcycloalkane derivatives of the formula I in which the substituents and symbols have the meanings indicated, possess an anticonvulsive and anxiolytic action and at the same time have low toxicity and neurotoxicity.