公开(公告)号：JP2007216030A

公开(公告)日：2007-08-30

申请号：JP2007035517

申请日：2007-02-15

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： MISCHLER REINHOLD ,  WERNER GERHARD

IPC: A61B5/1459 ,  A61B5/15 ,  A61B5/157 ,  G01N21/27

CPC classification number: A61B5/1459 ,  A61B5/0059 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/157 ,  A61B5/681 ,  A61B5/685 ,  G01N21/11 ,  G01N21/552

Abstract: PROBLEM TO BE SOLVED: To provide a miniaturized optical analytical system which can continuously analyze body fluid of a patient. SOLUTION: The sensor section has a hollow space extending from the distal end to the proximal end, wherein a needle array having at least one hollow needle suitable for lancing at the distal end. The proximal end of the needle is opened into a chamber in which liquid that enters through the distal end of the needle can be collected. A window which can be at least partially permeable to an infrared ray comes in direct contact with the chamber. By this sensor, the component concentration in body fluid can be measured based on the principle of ATR (attenuated total reflection). COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供可以连续分析患者体液的小型化的光学分析系统。 解决方案：传感器部分具有从远端延伸到近端的中空空间，其中针阵列具有至少一个适于在远端切开的中空针头。 针的近端被打开到其中可以收集通过针的远端进入的液体的腔室。 可以至少部分地透过红外线的窗口与腔室直接接触。 通过该传感器，可以基于ATR（衰减全反射）的原理来测量体液中的组分浓度。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：WO2004090779A3

公开(公告)日：2005-08-11

申请号：PCT/EP2004003613

申请日：2004-04-06

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  PETRICH WOLFANG ,  WERNER GERHARD ,  HEIN HEINZ-MICHAEL ,  KUHR HANS-JUERGEN

Inventor： PETRICH WOLFANG ,  WERNER GERHARD ,  HEIN HEINZ-MICHAEL ,  KUHR HANS-JUERGEN

IPC: G06F19/00

CPC classification number: G16H10/40 ,  G16H50/50

Abstract: The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.

Abstract translation: 本发明涉及的是适合于疾病的人类和动物样品中的诊断分析方法的字段。 本发明还公开了通过其使得可以诊断个体疾病阶段，使得疾病的过程可以被成像的评价方法。 这使得疾病和治疗监测的早期检测可以做到的等 本发明的方法使基获利本领域中已知的用于样品的多变量分类的评价方法。 然而，根据本发明的没有样品的一类分配，但在一组从不同类之间的内插得到的数据进行了分类不像在现有技术中发生的。

公开(公告)号：WO2012092954A3

公开(公告)日：2012-10-18

申请号：PCT/EP2011006500

申请日：2011-12-22

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

Inventor： STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

IPC: G09B23/00

CPC classification number: G06F19/70 ,  G09B23/28

Abstract: The invention relates to a method for evaluating a set of measurement data from an oral glucose tolerance test, wherein the set of measurement data contains a sequence of measurement data of the glucose concentration and, in addition, at least one sequence of measured values of a further analyte concentration. Provision is made according to the invention that, from the sequence of measured values of the glucose concentration and from in each case one of several predefined glucose sample profiles, in each case a value of a similarity measure is calculated that quantifies the similarity between the time profile of the sequence of measured values of the glucose concentration and the relevant glucose sample profile, and, from the sequence of measured values of the further analyte concentration and from several predefined analyte sample profiles, in each case a value of a further similarity measure is calculated that quantifies the similarity between the profile of the sequence of measured values of the further analyte concentration and the relevant analyte sample profile, the set of data is characterized, in a vector space having coordinate axes formed from the similarity measures, by a point whose coordinates contain the calculated values of the similarity measures, and the position of this point in relation to reference points that each represent a defined state of health is evaluated, in order to calculate a parameter that indicates the state of the glucose metabolism of the patient.

Abstract translation: 本发明涉及一种方法，用于评估一组口服葡萄糖耐受性测试的测量数据，其中，所述组测量数据包括中的葡萄糖浓度的测量数据的序列，和另一种分析物的测定值的附加的至少一种序列。 根据规定，在每种情况下的相似性度量的值是从葡萄糖浓度的测量值的序列来计算，并且在每种情况下，其量化的葡萄糖浓度和相应的葡萄糖模式历史的测量值的序列的时间进程之间的相似性几个预定葡萄糖样本的演变的一项的发明， 进一步的相似性中的一个值被从其他的分析物浓度的测量值的序列和多个预定的分析物样品的演变的量化其它分析物的浓度和相关的分析物模式历史的测量值的序列的形状之间的相似度计算，在矢量空间中的数据， 具有坐标由相似度措施形成的轴，其特征在于一个点的坐标包含的相似性度量的计算值，这点相对于的位置的基准点，每封 INEN定义健康代表，进行评估，以计算指示患者的葡萄糖代谢的状态的参数。

公开(公告)号：DK2661741T3

公开(公告)日：2019-06-24

申请号：DK11808833

申请日：2011-12-22

Applicant: HOFFMANN LA ROCHE

Inventor： STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

IPC: G09B23/00

公开(公告)号：AT430514T

公开(公告)日：2009-05-15

申请号：AT06021579

申请日：2006-10-14

Applicant: HOFFMANN LA ROCHE

Inventor： WERNER GERHARD ,  HAAR HANS-PETER

IPC: A61B5/00

Abstract: The lancet has a body (2) provided with a tip (3) for making an incision. The body has a capillary type channel (4) for extracting body fluid in a direction of flow (F) from the incision. The channel is formed by a slot that runs along the body perpendicular to the direction of flow. A test area is provided for visually examining a body fluid specimen conveyed from the channel. The area is formed as a section of the slot, and has a transparent component (30) with a moistening surface for moistening with the specimen to be examined. The slot is made of steel. An independent claim is also included for a pricking system for making an incision, comprising a pricking device.

公开(公告)号：ES2731459T3

公开(公告)日：2019-11-15

申请号：ES11808833

申请日：2011-12-22

Applicant: HOFFMANN LA ROCHE

Inventor： STAIB ARNULF ,  QUARDER ORTRUD ,  WERNER GERHARD

IPC: G09B23/00

Abstract: Un procedimiento para evaluar un conjunto de datos de medición de una prueba oral de tolerancia a la glucosa, en el que el conjunto de datos de medición contiene una secuencia de datos de medición de la concentración de glucosa y adicionalmente al menos una secuencia de valores de medición de otra concentración de analito, caracterizada por que un valor de una medida de similitud se calcula a partir de la secuencia de valores medidos de concentración de glucosa y uno de varios de los perfiles de referencia de glucosa predeterminados, que cuantifica la similitud entre el perfil de tiempo de la secuencia de mediciones de concentración de glucosa y el perfil de referencia de glucosa pertinente, un valor de otra medida de similitud se calcula a partir de la secuencia de valores medidos de otra concentración de analito y varios perfiles de referencia de analito predeterminados, que cuantifica la similitud entre el perfil de la secuencia de valores medidos de la otra concentración de analito y el perfil de referencia del analito pertinente, el conjunto de datos en un espacio vectorial que tiene ejes de coordenadas formados por las medidas de similitud se caracteriza por un punto cuyas coordenadas incluyen los valores calculados de las medidas de similitud, la posición de ese punto se evalúa con respecto a los puntos de referencia, cada uno de los cuales representa un estado de salud definido, para calcular un parámetro que indica el estado del metabolismo de la glucosa del paciente, en el que la posición del punto que caracteriza el conjunto de datos se evalúa con respecto a los puntos de referencia proyectando el punto en una trayectoria estándar que sigue una progresión de la enfermedad desde un paciente normal sano, pasando por un estado prediabético, hasta enfermedad diabética en el espacio vectorial e incluye al menos parte de los puntos de referencia, determinar, a partir de la longitud de una parte de la trayectoria desde el inicio de la trayectoria hasta el punto de la trayectoria en el que se proyectó el punto que representa el conjunto de datos, el parámetro que indica el estado del metabolismo de la glucosa.

公开(公告)号：CA2521921A1

公开(公告)日：2004-10-21

申请号：CA2521921

申请日：2004-04-06

Applicant: HOFFMANN LA ROCHE

Inventor： KUHR HANS-JUERGEN ,  WERNER GERHARD ,  PETRICH WOLFANG ,  HEIN HEINZ-MICHAEL

IPC: G06F19/00

Abstract: The invention relates to analysis methods for diagnosing diseases on human a nd animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeuti c controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class , but it is classified in a data record based on the interpolation between different classes.