公开(公告)号：EP2516503A4

公开(公告)日：2013-06-12

申请号：EP10839918

申请日：2010-12-23

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： HEDRICK JAMES LUPTON ,  FUKUSHIMA KAZUKI ,  YANG YI-YAN

IPC: C08G64/18 ,  A61K9/107 ,  C08G63/64 ,  C08G64/30

CPC classification number: C08G63/64 ,  A61K9/1075 ,  A61K31/14 ,  C08G64/18 ,  C08G64/30 ,  Y10S977/773 ,  Y10S977/904

Abstract: Biodegradable cationic block copolymers are disclosed, comprising a hydrophilic block comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a hydrophobic block comprising second repeat units derived from a second cyclic carbonyl monomer by ring-opening polymerization; an optional endcap group; and a chain fragment derived from an initiator for the ring opening polymerization. The cationic block copolymers form aqueous micelle mixtures suitable for antimicrobial applications.

公开(公告)号：WO2007014882A2

公开(公告)日：2007-02-08

申请号：PCT/EP2006064640

申请日：2006-07-25

Applicant: IBM ,  IBM UK ,  HEDRICK JAMES LUPTON ,  MAGBITANG TEDDIE PEREGRINO ,  SANKARAPANDIAN MUTHUMANICKAM ,  VOLKSEN WILLI ,  KIM HO-CHEOL ,  LEE VICTOR YEE-WAY ,  MILLER ROBERT DENNIS ,  SUNDBERG LINDA KARIN ,  DUBOIS GERAUD JEAN-MICHEL

Inventor： HEDRICK JAMES LUPTON ,  MAGBITANG TEDDIE PEREGRINO ,  SANKARAPANDIAN MUTHUMANICKAM ,  VOLKSEN WILLI ,  KIM HO-CHEOL ,  LEE VICTOR YEE-WAY ,  MILLER ROBERT DENNIS ,  SUNDBERG LINDA KARIN ,  DUBOIS GERAUD JEAN-MICHEL

CPC classification number: C08L101/12 ,  H01L21/02118 ,  H01L21/02126 ,  H01L21/02203 ,  H01L21/02216 ,  H01L21/02282 ,  H01L21/31695 ,  H01L21/76807 ,  H01L21/7682 ,  H01L2221/1047

Abstract: A composition of matter and a structure fabricated using the composition. The composition comprising; a resin; polymeric nano-particles dispersed in the resin, each of the polymeric nano-particle comprising a multi-arm core polymer and pendent polymers attached to the multi-arm core polymer, the multi-arm core polymer immiscible with the resin and the pendent polymers miscible with the resin; and a solvent, the solvent volatile at a first temperature, the resin cross-linkable at a second temperature, the polymeric nano-particle decomposable at a third temperature, the third temperature higher than the second temperature, the second temperature higher than the first temperature, wherein a thickness of a layer of the composition shrinks by less than about 3.5% between heating the layer from the second temperature to the third temperature.

Abstract translation: 使用该组合物制造的物质组成和结构。 该组合物包含： 树脂; 分散在树脂中的聚合物纳米颗粒，每种聚合物纳米颗粒包含多臂芯聚合物和连接到多臂芯聚合物上的侧链聚合物，与树脂不混溶的多臂芯聚合物和可混溶的侧链聚合物 与树脂; 和溶剂，所述溶剂在第一温度下是挥发性的，所述树脂在第二温度下可交联，所述聚合物纳米颗粒可在第三温度下分解，所述第三温度高于所述第二温度，所述第二温度高于所述第一温度 其中在将所述层从所述第二温度加热到所述第三温度之间，所述组合物层的厚度收缩小于约3.5％。

公开(公告)号：EP2516504A4

公开(公告)日：2013-06-05

申请号：EP10839919

申请日：2010-12-23

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： FUKUSHIMA KAZUKI ,  HEDRICK JAMES LUPTON ,  YANG YI YAN

IPC: C08G64/18 ,  C08G63/06 ,  C08G63/64 ,  C08G63/91 ,  C08G64/02 ,  C08G64/38 ,  C08G64/42 ,  C12N5/00

CPC classification number: C08G63/64 ,  A61K47/34 ,  C08G63/06 ,  C08G63/912 ,  C08G64/0208 ,  C08G64/0241 ,  C08G64/18 ,  C08G64/30 ,  C08G64/38 ,  C08G64/42 ,  C08G2261/126 ,  C12N5/0068 ,  C12N15/88 ,  C12N2533/30 ,  Y02P20/582

Abstract: A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening polymerization; and an optional endcap group. The biodegradable cationic polymers have low cytotoxicity and form complexes with biologically active materials useful in gene therapeutics and drug delivery.

公开(公告)号：WO2007096359A3

公开(公告)日：2008-01-10

申请号：PCT/EP2007051622

申请日：2007-02-20

Applicant: IBM ,  IBM UK ,  HEDRICK JAMES LUPTON ,  FROMMER JANE ELIZABETH ,  WINDELN JOHANNES ,  DUERIG URS ,  LEE VICTOR YEE-WAY ,  GOTSMANN BERND ,  MILLER ROBERT DENNIS ,  HAGBERG ERIK ,  MAGBITANG TEDDIE ,  KNOLL ARMIN ,  PRATT RUSSELL CLAYTON ,  WADE CHARLES

Inventor： HEDRICK JAMES LUPTON ,  FROMMER JANE ELIZABETH ,  WINDELN JOHANNES ,  DUERIG URS ,  LEE VICTOR YEE-WAY ,  GOTSMANN BERND ,  MILLER ROBERT DENNIS ,  HAGBERG ERIK ,  MAGBITANG TEDDIE ,  KNOLL ARMIN ,  PRATT RUSSELL CLAYTON ,  WADE CHARLES

IPC: C08G73/12 ,  G11B9/00

CPC classification number: G11B9/149 ,  B82Y10/00 ,  C08G73/101 ,  C08G73/1046 ,  C08G73/105 ,  C08G73/1053 ,  C08G73/1064 ,  G11B9/1409 ,  G11B9/1454 ,  G11B11/007 ,  G11B2005/0021 ,  Y10T428/265 ,  Y10T428/31721

Abstract: An approach is presented for designing a polymeric layer for nanometer scale thermo-mechanical storage devices. Cross-linked polyimide oligomers are used as the recording layers in atomic force data storage device, giving significantly improved performance when compared to previously reported cross-linked and linear polymers. The cross-linking of the polyimide oligomers may be tuned to match thermal and force parameters required in read-write-erase cycles. Additionally, the cross-linked polyimide oligomers are suitable for use in nano-scale imaging.

Abstract translation: 提出了一种用于设计用于纳米级热机械存储装置的聚合物层的方法。 交联聚酰亚胺低聚物用作原子力数据存储装置中的记录层，与先前报道的交联和线性聚合物相比，显着提高了性能。 可以调整聚酰亚胺低聚物的交联以匹配读写擦除周期中所需的热和强度参数。 另外，交联聚酰亚胺低聚物适用于纳米级成像。

公开(公告)号：EP2983679A4

公开(公告)日：2017-05-31

申请号：EP14782236

申请日：2014-03-31

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： COADY DANIEL JOSEPH ,  DIPIETRO RICHARD ANTHONY ,  ENGLER AMANDA CATHERINE ,  HEDRICK JAMES LUPTON ,  CHIN WILLY ,  LEE ASHLYNN L Z ,  NG VICTOR W L ,  ONG ZHAN-YUIN ,  YANG YI YAN

IPC: A61K31/785 ,  A01N33/12 ,  A61K31/80 ,  C08G64/02

CPC classification number: A61K31/785 ,  A01N33/12 ,  A61K31/80 ,  C08G64/0241 ,  A01N25/10

Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

Abstract translation: 通过有机催化开环聚合制备具有一个或两个阳离子聚碳酸酯链的抗微生物阳离子聚合物。 一种抗微生物阳离子聚合物具有基本上由连接至一个或两个端基的阳离子碳酸酯重复单元组成的聚合物链。 端基可以包含共价结合形式的生物活性化合物如胆固醇。 其它抗微生物阳离子聚合物具有无规共聚碳酸酯链，其包含具有共价结合形式的维生素E和/或维生素D2的疏水性重复单元的较小摩尔分数。 阳离子聚合物对革兰氏阴性和革兰氏阳性微生物和真菌表现出高活性和选择性。

公开(公告)号：EP2516502A4

公开(公告)日：2016-12-14

申请号：EP10839917

申请日：2010-12-23

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： HEDRICK JAMES LUPTON ,  NELSON ALSHAKIM ,  YANG CHUAN ,  YANG YI YAN

IPC: C08G64/18 ,  A61K9/107 ,  A61K47/34 ,  A61K47/48 ,  C08G63/664 ,  C08G65/00 ,  C08L71/02 ,  C12N5/00

CPC classification number: C12N5/0068 ,  A61K9/1075 ,  A61K47/34 ,  A61K47/549 ,  A61K47/6801 ,  A61K47/6907 ,  C08G63/664 ,  C08G64/183 ,  C08G2261/126 ,  C08L71/02 ,  C08L2203/02 ,  C08L2205/05 ,  C12N2533/30 ,  Y02P20/582 ,  C08L69/00

Abstract: A biodegradable block copolymer is disclosed, comprising a hydrophilic block derived from a polyether alcohol; and a hydrophobic block comprising a first repeat unit derived by ring opening polymerization of a first cyclic carbonyl monomer initiated by the polyether alcohol, the first repeat unit comprising a side chain moiety comprising a functional group selected from the group consisting of i) urea groups and ii) mixtures of urea groups and carboxylic acid groups. No side chain of the hydrophobic block comprises a covalently bound biologically active material. The block copolymer self-assembles in water forming micelles suitable for sequestering a biologically active material by a non-covalent interaction, and the block copolymer is 60% biodegraded within 180 days in accordance with ASTM D6400.

Abstract translation: 公开了一种可生物降解的嵌段共聚物，其包含衍生自聚醚醇的亲水性嵌段; 和疏水嵌段，其包含通过由所述聚醚醇引发的第一环状羰基单体的开环聚合衍生的第一重复单元，所述第一重复单元包含侧链部分，所述侧链部分包含选自以下的官能团：i）脲基团和 ii）脲基和羧酸基团的混合物。 疏水嵌段的侧链不包括共价结合的生物活性材料。 嵌段共聚物在水形成胶束中自组装，其适于通过非共价相互作用隔离生物活性材料，并且嵌段共聚物根据ASTM D6400在180天内生物降解60％。

公开(公告)号：EP2983692A4

公开(公告)日：2017-05-17

申请号：EP14782368

申请日：2014-03-27

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： COADY DANIEL JOSEPH ,  DIPIETRO RICHARD ANTHONY ,  ENGLER AMANDA CATHERINE ,  HEDRICK JAMES LUPTON ,  NG VICTOR W L ,  ONG ZHAN-YUIN ,  TAN JEREMY P K ,  YANG YI YAN

IPC: A61K38/10 ,  A01N33/12 ,  A01N43/50 ,  A01N57/34 ,  A61K9/00 ,  A61K31/337 ,  A61K31/765 ,  A61K47/50 ,  A61P31/00 ,  C08G63/64

CPC classification number: C08G63/64 ,  A01N33/12 ,  A01N43/50 ,  A01N57/34 ,  A61K9/0019 ,  A61K31/765 ,  A61K2800/54 ,  A61K2800/542 ,  A61K2800/5426 ,  C08G64/0233 ,  C08G64/0241 ,  C08G64/025 ,  C08G64/0258 ,  C08G64/0291 ,  C08G64/30 ,  A01N45/00

Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

Abstract translation: 具有一个或两个阳离子聚碳酸酯链的抗微生物阳离子聚合物通过有机催化开环聚合制备。 一种抗微生物阳离子聚合物具有基本上由连接到一个或两个端基的阳离子碳酸酯重复单元组成的聚合物链。 端基可以包含生物活性化合物如胆固醇的共价结合形式。 其他抗微生物阳离子聚合物具有无规共聚碳酸酯链，所述无规共聚碳酸酯链包含少量摩尔分数的具有共价结合形式的维生素E和/或维生素D 2的疏水性重复单元。 阳离子聚合物对革兰氏阴性和革兰氏阳性微生物和真菌表现出高活性和选择性。

公开(公告)号：EP2984117A4

公开(公告)日：2017-03-22

申请号：EP14782869

申请日：2014-03-31

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： HEDRICK JAMES LUPTON ,  LEE ASHLYNN L Z ,  NG VICTOR W L ,  YANG YI YAN

IPC: A61K9/06 ,  A61K31/74 ,  A61K47/34 ,  C08G64/18

CPC classification number: C08G64/183 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/355 ,  A61K31/592 ,  A61K31/593 ,  A61K39/395 ,  A61K47/34 ,  A61K47/551 ,  A61K47/60 ,  C08G65/3318 ,  C08G2210/00

Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.

公开(公告)号：WO2014168771A2

公开(公告)日：2014-10-16

申请号：PCT/US2014032313

申请日：2014-03-31

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： COADY DANIEL JOSEPH ,  DIPIETRO RICHARD ANTHONY ,  ENGLER AMANDA CATHERINE ,  HEDRICK JAMES LUPTON ,  CHIN WILLY ,  LEE ASHLYNN L Z ,  NG VICTOR W L ,  ONG ZHAN-YUIN ,  YANG YI YAN

IPC: A61K31/785 ,  A61K31/80

CPC classification number: A61K31/785 ,  A01N33/12 ,  A61K31/80 ,  C08G64/0241 ,  A01N25/10

Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

Abstract translation: 具有一个或两个阳离子聚碳酸酯链的抗微生物阳离子聚合物通过有机催化开环聚合制备。 一种抗微生物阳离子聚合物具有基本上由连接到一个或两个端基的阳离子碳酸酯重复单元组成的聚合物链。 端基可以包含生物活性化合物如胆固醇的共价结合形式。 其他抗微生物阳离子聚合物具有无规共聚碳酸酯链，所述无规共聚碳酸酯链包含少量摩尔分数的具有共价结合形式的维生素E和/或维生素D 2的疏水性重复单元。 阳离子聚合物对革兰氏阴性和革兰氏阳性微生物和真菌表现出高活性和选择性。

公开(公告)号：DE112014004266T5

公开(公告)日：2016-06-23

申请号：DE112014004266

申请日：2014-08-01

Applicant: IBM

Inventor： ALLEN ROBERT DAVID ,  BAJJURI KRISHNA MOHAN ,  BREYTA GREGORY ,  HEDRICK JAMES LUPTON ,  LARSON CARL ERIC

IPC: C07C51/09 ,  C08G63/00 ,  C08J11/18 ,  C08J11/24

Abstract: Vorgesehen wird ein Verfahren zur Depolymerisation von Polyester aus gebrauchten Produkten, wie Getränkeflaschen, zur Herstellung eines hochreinen Reaktionsprodukts. Für die Depolymerisationsreaktion werden die Polyester mit einem Alkohol mit 2 bis 5 Kohlenstoffen und einem Amin-Organokatalysator bei einer Temperatur von etwa 150 °C bis etwa 250 °C miteinander reagiert. In einer Anwendung ermöglicht die Verwendung eines Organokatalysators mit einem Siedepunkt, der wesentlich unter dem Siedepunkt des Alkohol-Reaktants liegt, das einfache Recycling des Amin-Organokatalysators. In einer anderen Anwendung ermöglicht die Durchführung der Depolymerisationsreaktion unter Druck bei einer Temperatur über der des Alkohols beschleunigte Depolymerisationsraten und die Rückgewinnung des Organokatalysators ohne weitere Wärmezufuhr. In einer weiteren Anwendung erzeugt die glykolitische Depolymerisation von Poly(ethylenterephthalat)(PET) aus gebrauchten Getränkeflaschen ein reines Reaktionsprodukt von Bis(2-hydroxyethyl)terephthalat (BHET), was wiederum zur Herstellung eines hochreinen PET in Getränkeflaschenqualität verwendet werden kann, in einem Closed Loop-Prozess mit minimalem Ausstoß und Abfall.