Microfluidic device with laterally insertable electrodes

    公开(公告)号:GB2581291A

    公开(公告)日:2020-08-12

    申请号:GB202006022

    申请日:2018-09-13

    Applicant: IBM

    Abstract: The invention is notably directed to a microfluidic device. The device comprises a substrate with a microchannel formed as a groove on a main surface of the substrate. The device further comprises one or more conduits extending parallel to the main surface of the substrate, and from a lateral surface of the substrate up to a lateral wall of the microchannel. The one or more conduits are configured so as to allow insertion of one or more electrodes therein, respectively, and such that an end of each of the one or more electrodes can reach into the microchannel. The invention is further directed to related sets of components, which include the above microfluidic device, as well as a housing, with electronics, and, possibly, a porous support (e.g., a membrane) and a cap. Biosensing applications are notably contemplated. The invention is further directed to methods of operating a microfluidic device.

    Microfluidic device with laterally insertable electrodes

    公开(公告)号:GB2581291B

    公开(公告)日:2022-11-23

    申请号:GB202006022

    申请日:2018-09-13

    Applicant: IBM

    Abstract: The invention is notably directed to a microfluidic device. The device comprises a substrate with a microchannel formed as a groove on a main surface of the substrate. The device further comprises one or more conduits extending parallel to the main surface of the substrate, and from a lateral surface of the substrate up to a lateral wall of the microchannel. The one or more conduits are configured so as to allow insertion of one or more electrodes therein, respectively, and such that an end of each of the one or more electrodes can reach into the microchannel. The invention is further directed to related sets of components, which include the above microfluidic device, as well as a housing, with electronics, and, possibly, a porous support (e.g., a membrane) and a cap. Biosensing applications are notably contemplated. The invention is further directed to methods of operating a microfluidic device.

    Biosensor electrode having three-dimensional structured sensing surfaces

    公开(公告)号:GB2575748B

    公开(公告)日:2022-07-13

    申请号:GB201915102

    申请日:2018-03-20

    Applicant: IBM

    Abstract: Embodiments of the invention include a method of using a sensor. The method includes accessing a sample and exposing the sample to the sensor. The sensor includes a sensing circuit having with a field effect transistor (FET) having a gate structure. A cavity is formed in a fill material that is over the gate structure. A probe of the sensor is within a portion of the cavity. An upper region of the probe is above a top surface of the fill material, and a lower region of the probe is below the top surface of the fill material. The probe structure includes a 3D sensing surface structure, and a liner is formed on the 3D sensing surface and configured to function as a recognition element. A portion of the liner is on the lower region of the probe and positioned between sidewalls of the cavity and the 3D sensing surface.

    Urine catheter pH sensor
    5.
    发明专利

    公开(公告)号:GB2565632A

    公开(公告)日:2019-02-20

    申请号:GB201810360

    申请日:2018-06-25

    Applicant: IBM

    Abstract: A system for 200 and method of sensing urine pH is presented which includes a urinary catheter tube 206 for insertion into a bladder of a patient, wherein the urine catheter tube includes an inner cavity, and a collection vessel 210 connected to the urinary catheter tube. A transistor (e.g. FET)-based pH sensing device 204 including a pH sensing surface (412, Fig 4) and a reference electrode (418, Fig 4) is also included; wherein in a first embodiment the pH sensing surface and the reference electrode have a surface exposed to the inner cavity. In a second embodiment urine pH is sensed by (i) applying a zero voltage to a collector (606, Fig 6) and the reference electrode, (ii) applying a voltage to an emitter (612, Fig 6) and (iii) measuring a current from the collector.

    Urine catheter pH sensor
    6.
    发明专利

    公开(公告)号:GB2565632B

    公开(公告)日:2020-03-11

    申请号:GB201810360

    申请日:2018-06-25

    Applicant: IBM

    Abstract: Embodiments of the present invention are directed to a system for sensing urine pH. A non-limiting example of the system includes a urinary catheter tube for insertion into a bladder of a patient, wherein the urine catheter tube includes an inner cavity. The system also includes a collection vessel connected to the urinary catheter tube. The system also includes a FET-based pH sensing device including a pH sensing surface and a reference electrode, wherein the pH sensing surface and the reference electrode have a surface exposed to the inner cavity. Such embodiments can advantageously provide a real-time, sensitive measurement of urine for timely detection and monitoring of the physiological condition of a subject with a miniaturized FET-based pH sensor.

    Biosensor electrode having three-dimensional structured sensing surfaces

    公开(公告)号:GB2575748A

    公开(公告)日:2020-01-22

    申请号:GB201915102

    申请日:2018-03-20

    Applicant: IBM

    Abstract: A sensor includes a sensing circuit (116, 126) and a probe (112, 122) communicatively coupled to the sensing circuit (116, 126). The probe (112, 122) includes a three-dimensional (3D) sensing surface coated with a recognition element and configured to, based at least in part on the 3D sensing surface interacting with a predetermined material, generate a first measurement. In some embodiments, the 3D sensing surface is shaped as a pyramid, a cone, or a cylinder to increase the sensing surface area over a two- dimensional (2D) sensing surface. In some embodiments, the 3D sensing facilitates penetration of the 3D sensing surface through the wall of the biological cell (142A).

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