Methods for detecting renal disease

    公开(公告)号:AU2016254226C1

    公开(公告)日:2022-11-24

    申请号:AU2016254226

    申请日:2016-05-02

    Applicant: IDEXX LAB INC

    Abstract: Methods for determining renal function in an animal subject, the method including measuring the concentration of β-aminoisobutyric acid (β-amino isobutyrate) (BAIB) in patients samples and determining the presence, likelihood, or progression of kidney disease as a result of structural damage, or mortality associated with kidney disease. The methods also include measuring the concentration of BAIB in combination is symmetrical dimethyl arginine (SDMA) and determining kidney disease based upon the concentrations of BAIB and SDMA in the samples. Anti-BAIB antibodies, BAIB-conjugates, and assay methods using the antibodies and conjugates are also disclosed.

    DETECTION OF SYMMETRICAL DIMETHYLARGININE

    公开(公告)号:CA3079011A1

    公开(公告)日:2019-04-25

    申请号:CA3079011

    申请日:2018-10-19

    Applicant: IDEXX LAB INC

    Abstract: The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods for detecting symmetrical dimethyl arginine (SDMA) in sample, such as a biological sample from an animal. The method includes detecting the presence or amount of SDMA in the sample by using an immunoassay format, such as a competitive immunoassay. The assay includes the use of antibodies to SDMA that are specific for SDMA and that have less affinity for other arginine derivatives.

    Methods for detecting renal disease

    公开(公告)号:AU2016254226A1

    公开(公告)日:2017-11-09

    申请号:AU2016254226

    申请日:2016-05-02

    Applicant: IDEXX LAB INC

    Abstract: Methods for determining renal function in an animal subject, the method including measuring the concentration of β-aminoisobutyric acid (β-amino isobutyrate) (BAIB) in patients samples and determining the presence, likelihood, or progression of kidney disease as a result of structural damage, or mortality associated with kidney disease. The methods also include measuring the concentration of BAIB in combination is symmetrical dimethyl arginine (SDMA) and determining kidney disease based upon the concentrations of BAIB and SDMA in the samples. Anti-BAIB antibodies, BAIB-conjugates, and assay methods using the antibodies and conjugates are also disclosed.

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