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    2.
    发明专利
    未知

    公开(公告)号：DE60229460D1

    公开(公告)日：2008-12-04

    申请号：DE60229460

    申请日：2002-03-01

    Applicant: KAO CORP

    Inventor： HOSHINO MASAHIDE ,  SAITO HIROAKI ,  SUGAI YOSHIYA ,  SUGIYAMA MITSURU ,  NISHIZAWA YOSHINORI ,  KATAYAMA YASUSHI

    IPC: A61K31/16 ,  A61Q19/00 ,  A61K8/42 ,  A61Q5/02 ,  A61Q17/00 ,  A61Q17/04

    Abstract: The present invention relates to a composition for external application, containing a diamide derivative represented by the following formula (1) : (wherein R 1a and R 1b are the same or different and each represents a C 1-23 hydrocarbon group, R 2a and R 2b are the same or different and each represents a divalent C 1-6 hydrocarbon group, R 3 s are the same or different and each represents a divalent C 2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application basically improves the water retaining ability and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.

    TRANSGLUTAMINASE ACTIVATOR
    4.
    发明公开
    TRANSGLUTAMINASE ACTIVATOR 审中-公开
    转谷氨酰胺酶AKTIVATOR

    公开(公告)号：EP2918280A4

    公开(公告)日：2016-06-15

    申请号：EP13831994

    申请日：2013-08-29

    Applicant: KAO CORP

    Inventor： ISHIKAWA JUNKO ,  MITSUNAGA SHINO ,  CHEN SHI ,  KAWASAKI AKIKO ,  SUGAI YOSHIYA ,  SHIMOTOYODOME YOSHIE ,  OYA NAOKI

    IPC: A61K36/18 ,  A61K8/49 ,  A61K8/60 ,  A61K8/97 ,  A61K36/19 ,  A61P17/00 ,  A61P17/16 ,  A61P43/00 ,  A61Q5/04 ,  A61Q5/06 ,  A61Q17/00 ,  A61Q19/00 ,  C12N9/10

    CPC classification number: A61K8/602 ,  A23L33/105 ,  A61K8/4973 ,  A61K8/97 ,  A61K36/19 ,  A61Q5/04 ,  A61Q17/00 ,  A61Q19/00 ,  C12N9/1044 ,  A61K2300/00

    Abstract: A transglutaminase activator containing at least one kind selected from the group consisting of an extract from Justicia procumbens, an extract from Peristrophe japonica, and a compound represented by Formula (1), as an active ingredient: wherein R 1 and R 2 represent a hydrogen atom, a hydroxyl group, or an alkoxy group having 1 to 4 carbon atoms; R 3 represents a hydrogen atom, or a group for forming a methylenedioxy group by bonding with R 2 ; R 4 and R 5 represent a hydrogen atom, or a group for forming a methylenedioxy group by bonding with each other; R 6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms, an acyloxy group having 1 to 4 carbon atoms, or a specific sugar residue.

    Abstract translation: 1.一种转谷氨酰胺酶活化剂，其特征在于，所述转谷氨酰胺酶活化剂含有选自由马蹄莲（Justicia procumbens）的提取物，蓖麻的提取物和式（1）所示的化合物作为活性成分的至少一种，其中R 1和R 2表示氢 原子，羟基或具有1至4个碳原子的烷氧基; R 3表示氢原子，或用R 2键合形成亚甲二氧基的基团。 R 4和R 5表示氢原子，或通过彼此键合形成亚甲二氧基的基团; R 6表示氢原子，羟基，碳原子数1〜5的烷氧基，碳原子数1〜4的酰氧基或特定的糖残基。

    Ceramide production promoter
    8.
    发明专利
    Ceramide production promoter 有权
    陶瓷生产促销

    公开(公告)号：JP2014133707A

    公开(公告)日：2014-07-24

    申请号：JP2013001334

    申请日：2013-01-08

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SHIMOBURU YOSHIE ,  HASHIMOTO CHU ,  ISHIKAWA JUNKO ,  SUGAI YOSHIYA

    IPC: A61K8/97 ,  A61K36/18 ,  A61K36/23 ,  A61K36/899 ,  A61P17/16 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/10

    Abstract: PROBLEM TO BE SOLVED: To provide a ceramide production promoter and a humectant.SOLUTION: A ceramide production promoter and a humectant contain extracts of at least one plant selected from the group consisting of Gentiana macrophylla Pall., Lophatherum gracile Brongn, Phyllostachys nigra (Loddiges) Munro var. henonis (Bean) Stapf, Achyranthes bidentata Blume, and Ammi visnaga as an active ingredient.

    Abstract translation: 要解决的问题：提供神经酰胺生产促进剂和保湿剂。解决方案：神经酰胺生产促进剂和保湿剂含有至少一种选自以下的植物的提取物：Gentiana macrophylla Pall。，Lophatherum gracile Brongn，Phyllostachys nigra（Loddiges ）Munro var。 henonis（豆）Stapf，Achyranthes bidentata Blume和Ammi visnaga作为活性成分。

    Transglutaminase activator
    9.
    发明专利
    Transglutaminase activator 有权
    转氨酶激活剂

    公开(公告)号：JP2014062089A

    公开(公告)日：2014-04-10

    申请号：JP2013178621

    申请日：2013-08-29

    Applicant: Kao Corp ,  花王株式会社

    Inventor： ISHIKAWA JUNKO ,  CHEN SHI ,  MITSUNAGA SHINO ,  SUGAI YOSHIYA ,  SHIMOBURU YOSHIE ,  OYA NAOKI

    IPC: A61K36/18 ,  A61K8/97 ,  A61P17/16 ,  A61P43/00 ,  A61Q5/04 ,  A61Q19/00 ,  A61Q19/08

    Abstract: PROBLEM TO BE SOLVED: To provide a transglutaminase activator that activates transglutaminase, a ceramide production accelerator that accelerates production of ceramide, and an involucrin expression accelerator that accelerates expression of involucrin.SOLUTION: A transglutaminase activator, a ceramide production accelerator, and an involucrin expression accelerator comprise an extract of a plant Peristrophe japonica as an active ingredient.

    Abstract translation: 要解决的问题：提供激活转谷氨酰胺酶的转谷氨酰胺酶活化剂，加速神经酰胺生产的神经酰胺生产促进剂和加速外皮蛋白的表达的外皮蛋白表达促进剂。解决方案：转谷氨酰胺酶激活剂，神经酰胺生产促进剂和外皮蛋白表达 促进剂包含作为活性成分的植物蓖麻的提取物。

    Method for producing n-acylamino triol
    10.
    发明专利
    Method for producing n-acylamino triol 有权
    N-亚氨基三醇的制备方法

    公开(公告)号：JP2013060381A

    公开(公告)日：2013-04-04

    申请号：JP2011199022

    申请日：2011-09-13

    Applicant: Kao Corp ,  花王株式会社

    Inventor： HASHIMOTO CHU ,  SUGAI YOSHIYA

    IPC: C07C231/02 ,  C07B61/00 ,  C07C233/18 ,  C07C235/08

    CPC classification number: C07C231/02 ,  C07C233/18 ,  C07C235/08

    Abstract: PROBLEM TO BE SOLVED: To provide a method for selectively N-acylating an amino triol to produce an N-acylated amino triol efficiently by a technique that is industrially advantageous.SOLUTION: In this method for producing an N-acylamino triol represented by formula (1), an amino triol represented by formula (2) and a fatty acid ester represented by formula (3) are reacted in the presence of a basic catalyst in ethanol and/or methanol. (In the formulae, Rrepresents an 8-20C saturated or unsaturated aliphatic hydrocarbon group; Rrepresents a 7-29C saturated or unsaturated aliphatic hydrocarbon group which may have a hydroxy group; and Rrepresents a 1-6C alkyl group).

    Abstract translation: 待解决的问题：提供通过工业上有利的技术有效地提供选择性N-酰化氨基三醇以产生N-酰化氨基三醇的方法。 解决方案：在制备由式（1）表示的N-酰基氨基三醇的方法中，式（2）表示的氨基三醇和由式（3）表示的脂肪酸酯在碱存在下反应 乙醇和/或甲醇中的催化剂。 （式中，R 1 表示8-20℃饱和或不饱和脂族烃基; R 2 表示7-29C 可以具有羟基的饱和或不饱和脂族烃基; R 6表示1-6C烷基。 版权所有（C）2013，JPO＆INPIT

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