公开(公告)号：AU2006320916A1

公开(公告)日：2007-06-07

申请号：AU2006320916

申请日：2006-10-03

Applicant: KIONIX INC

Inventor： ZHOU PENG ,  YOUNG LICOLN

IPC: B01L3/00 ,  B32B27/00 ,  F04B43/04 ,  F04B53/10

Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

公开(公告)号：EP1706467A4

公开(公告)日：2007-09-26

申请号：EP04795012

申请日：2004-10-13

Applicant: KIONIX INC

Inventor： ZHOU PENG ,  YOUNG LINCOLN C

IPC: C09J5/10 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC classification number: B29C66/54 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B29C65/4815 ,  B29C65/483 ,  B29C65/4895 ,  B29C66/543 ,  B29C66/71 ,  B29L2031/756 ,  B29K2069/00 ,  B29K2033/08 ,  B29K2025/06

Abstract: A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.

公开(公告)号：AU2003234566A1

公开(公告)日：2003-12-22

申请号：AU2003234566

申请日：2003-05-13

Applicant: KIONIX INC

Inventor： ZHOU PENG ,  PINNISI MICHAEL D ,  MARUSAK RONALD E ,  MOON JAMES E ,  YOUNG LINCOLN C

IPC: B01D11/04 ,  B01F5/00 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N1/34 ,  G01N30/00 ,  G01N30/38 ,  G01N30/40 ,  G01N30/42 ,  G01N30/52 ,  G01N30/60

Abstract: Devices for performing liquid extraction of one or more constituents from one fluid to another fluid are provided. In operation, the fluids are separated by channel structures that stabilize the interfacial boundary between the fluids allowing, for example, countercurrent flow and exchange or other flow conditions incompatible with unassisted maintenance of laminar flow. Also provided are channel structures which aid in mixing the fluids. Thin membranes may be formed using liquid extraction devices according to the invention. A process for manufacturing such devices using DRIE is described.

公开(公告)号：WO2007084425A3

公开(公告)日：2009-04-02

申请号：PCT/US2007000960

申请日：2007-01-12

Applicant: KIONIX INC ,  ZHOU PENG ,  YOUNG LINCOLN

Inventor： ZHOU PENG ,  YOUNG LINCOLN

IPC: B01L3/00

CPC classification number: G01N1/28 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/00 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/0633 ,  B01L2400/0655 ,  B01L2400/0666 ,  B01L2400/084 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T436/117497 ,  Y10T436/2575

Abstract: The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient an accurate approach for conducting parallel assays.

Abstract translation: 本文所述的系统和方法包括具有互连以提供用于处理至少一种试剂的可配置流体输送系统的多个微特征的微流体芯片。 提供插入件可移除地与芯片的一个或多个微特征相配合，其中插入物包括与试剂相互作用的位点。 从以下描述可以看出，微流控芯片和插入物提供了用于进行平行测定的有效的准确方法。

公开(公告)号：WO2007084425A9

公开(公告)日：2007-11-29

申请号：PCT/US2007000960

申请日：2007-01-12

Applicant: KIONIX INC ,  ZHOU PENG ,  YOUNG LINCOLN

Inventor： ZHOU PENG ,  YOUNG LINCOLN

IPC: B01L3/00

CPC classification number: G01N1/28 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/00 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2400/0481 ,  B01L2400/0622 ,  B01L2400/0633 ,  B01L2400/0655 ,  B01L2400/0666 ,  B01L2400/084 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T436/117497 ,  Y10T436/2575

Abstract: The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient an accurate approach for conducting parallel assays.

Abstract translation: 本文描述的系统和方法包括微流体芯片，其具有互连的多个微特征以提供用于处理至少一种试剂的可配置流体输送系统。 提供插入件以可移除地互相嵌入芯片的一个或多个微特征中，其中插入件包括用于与试剂相互作用的位点。 从以下描述中可以看出，微流体芯片和插入物为进行平行测定提供了有效的准确方法。

公开(公告)号：WO2007064404A8

公开(公告)日：2008-04-24

申请号：PCT/US2006039135

申请日：2006-10-03

Applicant: KIONIX INC ,  YOUNG LINCOLN ,  ZHOU PENG

Inventor： YOUNG LINCOLN ,  ZHOU PENG

IPC: B01L3/00 ,  B32B27/00 ,  F04B43/04 ,  F04B53/10

CPC classification number: F16K7/12 ,  B01F5/0683 ,  B01F5/0688 ,  B01F11/0071 ,  B01F13/0059 ,  B01F2215/0034 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/06 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/084 ,  B29C65/4895 ,  B29C66/004 ,  B29C66/54 ,  B29C66/5412 ,  B29C66/71 ,  B29K2025/00 ,  B29K2025/04 ,  B29K2033/08 ,  B29K2069/00 ,  B29K2101/12 ,  B29L2031/7496 ,  B29L2031/7506 ,  B29L2031/756 ,  B81B3/0021 ,  B81B2201/036 ,  B81B2201/054 ,  B81B2203/0127 ,  B81C1/00103 ,  B81C1/00158 ,  F04B43/028 ,  F04B43/043 ,  F04B43/06 ,  F15C1/08 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0021 ,  F16K99/0034 ,  F16K99/0055 ,  F16K99/0057 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T29/49405 ,  Y10T137/212 ,  Y10T137/2202 ,  Y10T137/2218 ,  Y10T137/8593 ,  Y10T137/85978 ,  Y10T156/1002 ,  Y10T156/1043 ,  B29K2033/12 ,  B29K2025/06

Abstract: Plastic microfluidic structures having a substantially rigid diaphragm that actuates between a relaxed state wherein the diaphragm sits against the surface of a substrate and an actuated state wherein the diaphragm is moved away from the substrate. As will be seen from the following description, the microfluidic structures formed with this diaphragm provide easy to manufacture and robust systems, as well readily made components such as valves and pumps.

Abstract translation: 塑料微流体结构具有基本上刚性的膜片，其在松弛状态之间起作用，其中隔膜抵靠衬底的表面，以及致动状态，其中隔膜移动离开衬底。 从以下描述可以看出，用这种隔膜形成的微流体结构提供易于制造和坚固的系统，以及易于制造的部件，例如阀和泵。

公开(公告)号：WO2004103562A3

公开(公告)日：2005-06-30

申请号：PCT/US2004014811

申请日：2004-05-12

Applicant: KIONIX INC ,  ZHOU PENG ,  YOUNG LINCOLN

Inventor： ZHOU PENG ,  YOUNG LINCOLN

IPC: B01L3/00 ,  B01L9/00 ,  B01L99/00 ,  G01N30/60 ,  G01N21/00 ,  B01L3/02 ,  B01L11/00 ,  G01N15/06 ,  G01N31/22 ,  G01N33/00 ,  G01N33/48

CPC classification number: B01L3/502715 ,  B01J2219/0081 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/043 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2300/0874 ,  G01N30/6082 ,  G01N30/6095 ,  Y10T29/49 ,  Y10T29/49002 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  G01N30/74 ,  G01N30/6047 ,  G01N2030/8881

Abstract: A reconfigurable modular microfluidic system, providing a microfluidic breadboard platform for the formation of fluidic network and fluidic sealing upon a system assembly. Modular microfluidic elements or "chips" are arranged on a precisely machined alignment base to form a fluidic network, with fluid connections provided directly from chip-to-chip at overlapping corners. Fluidic access to external devices is possible at every fluid connection and through special ingress/egress chips. By maintaining a largely planar layout, optical access is provided for detecting or visualization for every chip. The assembly may be covered by a perforated cover plate.

Abstract translation: 可重构模块化微流体系统，提供用于在系统组件上形成流体网络和流体密封的微流体面包板平台。 模块化微流体元件或“芯片”被布置在精确加工的对准基底上以形成流体网络，其中在重叠的角落处直接从芯片到芯片提供流体连接。 在每个流体连接和特殊的入口/出口芯片处都可以对外部设备进行流体访问。 通过维持大体平面的布局，提供了光学访问，用于每个芯片的检测或可视化。 组件可以被穿孔盖板覆盖。