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1.发明公开HESPERIDIN AND HESPERETIN AS INHIBITOR OF ACYL COA-CHOLESTEROL-O-ACYLTRANSFERASE, INHIBITOR OFMACROPHAGE-LIPID COMPLEX ACCUMULATION ON THE ARTERIAL WALL AND PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 审中-公开橙皮苷和橙皮素作为酰基COA胆固醇 - 酰基转移酶抑制剂，巨噬细胞脂质复合物对动脉壁的抑制剂;以及用于预防和治疗肝病的
公开(公告)号：EP1063988A1
公开(公告)日：2001-01-03
申请号：EP98951777.6
申请日：1998-10-20
Applicant: Korea Institute of Science and Technology
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang-Kyu , LEE, Chui Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , LEE, Jun Sung , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
IPC: A61K31/35
CPC classification number: A23L2/56 , A23L33/105 , A23V2002/00 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of hesperidin or hesperetin for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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2.发明授权NARINGIN AND NARINGENIN AS PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 有权柚皮甙柚皮素和预防的手段，肝脏疾病的治疗
公开(公告)号：EP1032381B1
公开(公告)日：2003-09-03
申请号：EP98951776.8
申请日：1998-10-20
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang Kyu , LEE, Chul Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
CPC classification number: A61K31/7048 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of naringin or naringenin for inhibiting the activity of acyl CoA-cholestrol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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3.发明公开NARINGIN AND NARINGENIN AS INHIBITOR OF ACYL COA-CHOLESTEROL-O-ACYLTRANSFERASE, INHIBITOR OF MACROPHAGE-LIPID COMPLEX ACCUMULATION ON THE ARTERIAL WALL AND PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 有权柚皮苷柚皮素和AS酰基辅酶A胆固醇-O-酰基转移抑制剂，用作积累AKROPHAG - 脂质复合物对动脉壁的抑制剂;以及用于预防和治疗肝病的
公开(公告)号：EP1032381A1
公开(公告)日：2000-09-06
申请号：EP98951776.8
申请日：1998-10-20
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang Kyu , LEE, Chul Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
CPC classification number: A61K31/7048 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of naringin or naringenin for inhibiting the activity of acyl CoA-cholestrol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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