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1.发明公开HESPERIDIN AND HESPERETIN AS INHIBITOR OF ACYL COA-CHOLESTEROL-O-ACYLTRANSFERASE, INHIBITOR OFMACROPHAGE-LIPID COMPLEX ACCUMULATION ON THE ARTERIAL WALL AND PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 审中-公开橙皮苷和橙皮素作为酰基COA胆固醇 - 酰基转移酶抑制剂，巨噬细胞脂质复合物对动脉壁的抑制剂;以及用于预防和治疗肝病的
公开(公告)号：EP1063988A1
公开(公告)日：2001-01-03
申请号：EP98951777.6
申请日：1998-10-20
Applicant: Korea Institute of Science and Technology
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang-Kyu , LEE, Chui Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , LEE, Jun Sung , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
IPC: A61K31/35
CPC classification number: A23L2/56 , A23L33/105 , A23V2002/00 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of hesperidin or hesperetin for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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2.发明授权NARINGIN AND NARINGENIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效UND柚皮苷柚皮素对3-羟基-3-甲基辅酶A（HMG-CoA）还原酶缝边
公开(公告)号：EP1014968B1
公开(公告)日：2004-02-18
申请号：EP97944200.1
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of naringin or naringenin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of naringin or naringenin.
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公开(公告)号：EP1069834A1
公开(公告)日：2001-01-24
申请号：EP99912147.8
申请日：1999-04-07
Applicant: Korea Institute of Science and Technology
Inventor： BOK, Song Hae , JEONG, Tae Sook , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , KWON, Yong Kook , HYUN, Byung Hwa , CHOI, Yang Kyu , LEE, Chul Ho , MOON, Surk Sik
IPC: A23L1/22
CPC classification number: A61K36/725 , A23L27/105 , A61K36/75 , A61K36/752 , A61K36/8962 , A61K36/899 , A61K36/9068 , A61K2300/00
Abstract: The present invention relates to a spice composition comprising 1 to 30 % by weight of garlic, 10 to 50 % by weight of onion, 0.2 to 10 % by weight of ginger, 5 to 40 % by weight of jujube, and 10 to 50 % by weight of citrus peel or an extract thereof or 1 to 20 % by weight of naringin or hesperidin.
Abstract translation: 本发明涉及一种香料组合物，其包含1至30重量％的大蒜，10至50重量％的洋葱，0.2至10重量％的姜，5至40重量％的枣和10至50重量％ 的柑橘皮或其提取物或1至20重量％的柚皮苷或橙皮苷。
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4.发明公开NARINGIN AND NARINGENIN AS INHIBITOR OF ACYL COA-CHOLESTEROL-O-ACYLTRANSFERASE, INHIBITOR OF MACROPHAGE-LIPID COMPLEX ACCUMULATION ON THE ARTERIAL WALL AND PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 有权柚皮苷柚皮素和AS酰基辅酶A胆固醇-O-酰基转移抑制剂，用作积累AKROPHAG - 脂质复合物对动脉壁的抑制剂;以及用于预防和治疗肝病的
公开(公告)号：EP1032381A1
公开(公告)日：2000-09-06
申请号：EP98951776.8
申请日：1998-10-20
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang Kyu , LEE, Chul Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
CPC classification number: A61K31/7048 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of naringin or naringenin for inhibiting the activity of acyl CoA-cholestrol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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5.发明公开HESPERIDIN AND HESPERETIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效橙皮苷和橙皮AS 3-羟基-3-甲基COA（HMG-CoA）还原酶抑制剂
公开(公告)号：EP0957911A1
公开(公告)日：1999-11-24
申请号：EP97944199.0
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of hesperidin or hesperetin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of hesperidin or hesperetin.
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Patent Agency Ranking6.发明授权NARINGIN AND NARINGENIN AS PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 有权柚皮甙柚皮素和预防的手段，肝脏疾病的治疗
公开(公告)号：EP1032381B1
公开(公告)日：2003-09-03
申请号：EP98951776.8
申请日：1998-10-20
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang Kyu , LEE, Chul Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
CPC classification number: A61K31/7048 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of naringin or naringenin for inhibiting the activity of acyl CoA-cholestrol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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7.发明授权CITRUS PEEL EXTRACT AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效ZITRUSSCHALENEXTRAKT TO 3-羟基-3-甲基辅酶A（HMG-CoA）的抑制剂reduktor
公开(公告)号：EP0930889B1
公开(公告)日：2002-12-18
申请号：EP97944201.9
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
IPC: A61K35/78
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of citrus peel extract as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity comprises an effective amount of citrus peel extract.
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8.发明授权HESPERIDIN AND HESPERETIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效橙皮苷和橙皮AS 3-羟基-3-甲基COA（HMG-CoA）还原酶抑制剂
公开(公告)号：EP0957911B1
公开(公告)日：2004-03-10
申请号：EP97944199.5
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
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公开(公告)号：EP1069834B1
公开(公告)日：2004-01-28
申请号：EP99912147.8
申请日：1999-04-07
Applicant: Korea Institute of Science and Technology
Inventor： BOK, Song Hae , JEONG, Tae Sook , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , KWON, Yong Kook , HYUN, Byung Hwa , CHOI, Yang Kyu , LEE, Chul Ho , MOON, Surk Sik
IPC: A23L1/22
CPC classification number: A61K36/725 , A23L27/105 , A61K36/75 , A61K36/752 , A61K36/8962 , A61K36/899 , A61K36/9068 , A61K2300/00
Abstract: The present invention relates to a spice composition comprising 1 to 30 % by weight of garlic, 10 to 50 % by weight of onion, 0.2 to 10 % by weight of ginger, 5 to 40 % by weight of jujube, and 10 to 50 % by weight of citrus peel or an extract thereof or 1 to 20 % by weight of naringin or hesperidin.
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10.发明公开NARINGIN AND NARINGENIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效柚皮苷，柚皮素和AS 3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂
公开(公告)号：EP1014968A1
公开(公告)日：2000-07-05
申请号：EP97944200.1
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of naringin or naringenin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of naringin or naringenin.
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