公开(公告)号：SG11201401917QA

公开(公告)日：2014-09-26

申请号：SG11201401917Q

申请日：2012-09-28

Applicant: LIFE TECHNOLOGIES CORP

Inventor： JANAWAY GORDON ,  ALIMINATI MANJULA ,  WU RUOYUN ,  FORTESCUE DAVID ,  SHEN MING

IPC: C12Q1/68 ,  G16B45/00

Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting of emission data from a planiality of samples, each included in a sample region of a plurality of sample regions, at a first time amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data, A dPCR result is generated based on the positive amplification determinations for the plurality of samples.

公开(公告)号：SG11202101612SA

公开(公告)日：2021-03-30

申请号：SG11202101612S

申请日：2019-08-29

Applicant: LIFE TECHNOLOGIES CORP

Inventor： CHU YONG ,  MAJUMBAR NIVEDITA ,  ALIMINATI MANJULA ,  CHEN YONGZHI ,  PAPENFUSS KEVIN

IPC: G06N3/04 ,  G01N35/00 ,  G01N35/02 ,  G06N3/08 ,  G06T7/00

Abstract: A system and methods are provided for image driven quality control for array based PCR. The system comprises a PCR unit, a reaction array plate, a convolutional neural network (CNN) configured to receive a sequence of images of the reaction array plate in the PCR system, and an output of the CNN coupled to a control for the reaction array plate. The method comprises applying a sequence of images from a plurality of subarrays of the reaction array plate to a plurality of CNNs during operation of the PCR system on the reaction plate array, operating the CNNs to generate failure mode predictions for the reaction plate based on the sequence of images, and coupling an output of the CNNs to one or more of a setting for manufacture of the reaction array plate or to control the PCR system.

公开(公告)号：SG10201604446PA

公开(公告)日：2016-07-28

申请号：SG10201604446P

申请日：2012-09-28

Applicant: LIFE TECHNOLOGIES CORP

Inventor： JANAWAY GORDON ,  ALIMINATI MANJULA ,  WU RUOYUN ,  FORTESCUE DAVID ,  SHEN MING

IPC: G16B45/00

Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting of emission data from a planiality of samples, each included in a sample region of a plurality of sample regions, at a first time amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data, A dPCR result is generated based on the positive amplification determinations for the plurality of samples.

公开(公告)号：IN3407DEN2014A

公开(公告)日：2015-06-05

申请号：IN3407DEN2014

申请日：2014-04-28

Applicant: LIFE TECHNOLOGIES CORP

Inventor： JANAWAY GORDON ,  ALIMINATI MANJULA ,  WU RUOYUN ,  FORTESCUE DAVID ,  SHEN MING

IPC: C12Q1/68 ,  G16B45/00

Abstract: A computer implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples each included in a sample region of a plurality of sample regions at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.