公开(公告)号：EP2057435A4

公开(公告)日：2011-04-20

申请号：EP07798040

申请日：2007-06-01

Applicant: LIFE TECHNOLOGIES CORP

Inventor： BOEGE STEVEN J ,  SHERIDAN JOHN ANDREW ,  ASLAM ALI P ,  LEHTO DENNIS ,  FOCARACCI JULIO ,  DROMARETSKY ALEXANDER ,  AU THOMAS C ,  OLDHAM MARK F ,  HENDERSON ERIC G ,  MIRCHANDANI VINOD ,  NORDMAN ERIC S ,  HABERSTROH MARC ,  SLUIS JOHANNES PAUL

IPC: C12Q1/68 ,  C07H21/04 ,  C12M1/00 ,  C12M1/36 ,  C12P19/34 ,  G01N15/06

CPC classification number: B01L7/52 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2300/185

Abstract: A device for performing biological analysis may include at least one reaction chamber configured to receive at least one sample for biological analysis and a thermal system configured to modulate a temperature of the at least one reaction chamber to cycle a temperature of the at least one biological sample. The thermal system may include a cooling system configured to cool the at least one reaction chamber. The cooling system may include a cooling fluid source positioned distally from the at least one reaction chamber, the cooling fluid source being in flow communication with at least one conduit configured to flow cooling fluid from the cooling fluid source to at least one location in thermal communication with the at least one reaction chamber.

公开(公告)号：EP1885839A4

公开(公告)日：2015-05-27

申请号：EP06751668

申请日：2006-04-26

Applicant: LIFE TECHNOLOGIES CORP

Inventor： YUE MIN ,  LIU DAVID M ,  CHIANG YUH-MIN ,  YANG JOON MO ,  LEHTO DENNIS ,  VANN CHARLES S ,  BEARD NIGEL P ,  HARDING IAN A ,  VAN CAMP JOHN ,  DROMARETSKY ALEXANDER ,  ERMAKOV SERGEY V ,  OLDHAM MARK F ,  ROY JOY ,  SHARIATI MARYAM ,  ULMANELLA UMBERTO

IPC: B01L3/00 ,  C12Q1/68 ,  G01N35/02

CPC classification number: C12Q1/6806 ,  B01J2219/00317 ,  B01J2219/00722 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50853 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/041 ,  B01L2300/048 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0694 ,  G01N35/028 ,  Y10T436/2575

Abstract: Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.

Abstract translation: 用于多个分析物检测的系统和方法包括用于分配包括衬底的生物样品的系统，其中所述衬底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。 该系统可以进一步包括包含在每个样品室中并被配置用于对进入基底的生物样品进行核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止 每个样品室中包含的样品不会从每个样品室流出。 底物可以由检测兼容和测定相容的材料构成。