公开(公告)号：WO2016090076A3

公开(公告)日：2016-08-11

申请号：PCT/US2015063593

申请日：2015-12-03

Applicant: LIFE TECHNOLOGIES CORP

Inventor： ZHOU WENJUN ,  GEE KYLE ,  TENNICO YOLANDA ,  SLADE PETER ,  KANG HEE CHOL ,  KHAN SHAHEER ,  EVANS BRIAN ,  STRAY JAMES

IPC: C07D261/00 ,  G01N33/58

CPC classification number: C07C309/47 ,  C07C309/51 ,  C07C2603/50 ,  C07D311/84 ,  G01N33/582 ,  G01N2400/10

Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.

Abstract translation: 本公开内容涉及含有肼基取代基和任选地一个或多个带负电基团（例如磺酸根，磷酸根，膦酸根和/或羧酸根基团）和含有氨氧基取代基的染料化合物的染料化合物。 这些化合物可用于检测含有醛和酮基的分析物，包括例如聚糖。

公开(公告)号：EP2742347A4

公开(公告)日：2015-04-08

申请号：EP12823779

申请日：2012-08-10

Applicant: LIFE TECHNOLOGIES CORP

Inventor： SLADE PETER

IPC: G01N33/48 ,  C12Q1/34 ,  G01N27/447 ,  G01N33/52 ,  G01N33/68

CPC classification number: G01N33/6842 ,  C12Q1/34 ,  G01N27/44726 ,  G01N27/44782 ,  G01N27/44791 ,  G01N33/6803 ,  G01N2333/924 ,  G01N2400/00 ,  G01N2400/38

Abstract: An apparatus for glycan analysis is disclosed. The apparatus includes a plurality of loading wells adapted to receive a plurality of samples; a plurality of capillaries arranged in correspondence with the loading wells, each of the capillaries including a first portion including a stacking gel and a second portion including a resolving gel; and a plurality of eluting wells arranged in correspondence with the capillaries and adapted to receive a portion of the samples having traversed the capillaries.

Abstract translation: 公开了一种用于聚糖分析的装置。 该装置包括适于接收多个样本的多个装载井; 多个毛细管，其布置成与所述装载孔相对应，每个所述毛细管包括包括堆积凝胶的第一部分和包括分解凝胶的第二部分; 以及与毛细管相对应地布置并适于接收穿过毛细管的一部分样品的多个洗脱液。