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    GENE EDITING REAGENTS WITH REDUCED TOXICITY
    1.
    发明申请
    GENE EDITING REAGENTS WITH REDUCED TOXICITY 审中-公开
    具有降低毒性的基因编辑试剂

    公开(公告)号：WO2017184799A1

    公开(公告)日：2017-10-26

    申请号：PCT/US2017/028482

    申请日：2017-04-20

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： POTTER, Robert ,  CARTE, Jason

    IPC: C12N15/11 ,  C12N15/10

    Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents. Further disclosed are nucleic acid compositions with reduced cytotoxicity.

    Abstract translation: 本公开总体上涉及用于细胞遗传修饰的组合物和方法。 特别地，本公开涉及CRISPR试剂和这些试剂的用途。 还公开了具有降低的细胞毒性的核酸组合物。

    STABILIZED REAGENTS FOR GENOME MODIFICATION
    2.
    发明申请
    STABILIZED REAGENTS FOR GENOME MODIFICATION 审中-公开
    稳定的基因组修饰试剂

    公开(公告)号：WO2017087842A1

    公开(公告)日：2017-05-26

    申请号：PCT/US2016/062844

    申请日：2016-11-18

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： POTTER, Robert Jason ,  RAVINDER, Namritha ,  CARTE, Jason

    IPC: C12N15/10 ,  C12N9/96

    CPC classification number: C12N15/1003 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/22

    Abstract: The present disclosure generally relates to compositions and methods for genetic modification of cells. In particular, the disclosure relates to stabilized reagents for genome alteration ( e.g ., site specific nucleases), as well as stabilized reagents for non-genetic code altering modification ( e.g ., DNA methylation). Stabilization methods include storage of reagents at suitable temperatures, conversion to dry forms, and chemical modifications.

    Abstract translation: 本公开总体上涉及用于细胞遗传修饰的组合物和方法。 具体而言，本公开涉及用于基因组改变（例如，位点特异性核酸酶）的稳定化试剂以及用于非遗传密码改变修饰（例如，）的稳定化试剂。 ，DNA甲基化）。 稳定化方法包括在合适的温度下储存试剂，转化为干燥形式和化学修饰。

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