公开(公告)号：WO2016057951A3

公开(公告)日：2016-04-14

申请号：PCT/US2015/054986

申请日：2015-10-09

Applicant: LIFE TECHNOLOGIES CORPORATION ,  THERMO FISHER SCIENTIFIC GENEART GMBH

Inventor： RAVINDER, Namritha ,  HEIL, Korbinian ,  GUO, Yizhu ,  LIANG, Xiquan ,  POTTER, Robert

IPC: C12Q1/68 ,  C12N15/113 ,  C12N15/10

Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

公开(公告)号：WO2017205650A1

公开(公告)日：2017-11-30

申请号：PCT/US2017/034520

申请日：2017-05-25

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： LIANG, Xiquan ,  POTTER, Robert ,  RAVINDER, Namritha ,  KUMAR, Shantanu

IPC: C12N15/10 ,  C12N15/90

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract translation: 本公开总体上涉及用于改善同源重组效率的组合物和方法。 具体而言，本公开涉及试剂和这些试剂的用途。

公开(公告)号：WO2017087842A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062844

申请日：2016-11-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： POTTER, Robert Jason ,  RAVINDER, Namritha ,  CARTE, Jason

IPC: C12N15/10 ,  C12N9/96

CPC classification number: C12N15/1003 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/22

Abstract: The present disclosure generally relates to compositions and methods for genetic modification of cells. In particular, the disclosure relates to stabilized reagents for genome alteration ( e.g ., site specific nucleases), as well as stabilized reagents for non-genetic code altering modification ( e.g ., DNA methylation). Stabilization methods include storage of reagents at suitable temperatures, conversion to dry forms, and chemical modifications.

Abstract translation: 本公开总体上涉及用于细胞遗传修饰的组合物和方法。 具体而言，本公开涉及用于基因组改变（例如，位点特异性核酸酶）的稳定化试剂以及用于非遗传密码改变修饰（例如，）的稳定化试剂。 ，DNA甲基化）。 稳定化方法包括在合适的温度下储存试剂，转化为干燥形式和化学修饰。

公开(公告)号：EP3464587A1

公开(公告)日：2019-04-10

申请号：EP17731961.3

申请日：2017-05-25

Applicant: Life Technologies Corporation

Inventor： LIANG, Xiquan ,  POTTER, Robert ,  RAVINDER, Namritha ,  KUMAR, Shantanu

IPC: C12N15/10 ,  C12N15/90

公开(公告)号：EP3998344A1

公开(公告)日：2022-05-18

申请号：EP21198861.3

申请日：2015-10-09

Applicant: Life Technologies Corporation ,  Thermo Fisher Scientific GENEART GmbH

Inventor： RAVINDER, Namritha ,  HEIL, Korbinian ,  GUO, Yizhu ,  LIANG, Xiquan ,  POTTER, Robert

IPC: C12Q1/68 ,  C12N15/113 ,  C12N15/10 ,  C12N15/90

Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

公开(公告)号：EP3377626A1

公开(公告)日：2018-09-26

申请号：EP16819717.6

申请日：2016-11-18

Applicant: Life Technologies Corporation

Inventor： POTTER, Robert Jason ,  RAVINDER, Namritha ,  CARTE, Jason

IPC: C12N15/10 ,  C12N9/96

CPC classification number: C12N15/1003 ,  C07K2319/80 ,  C07K2319/81 ,  C12N9/22

Abstract: The present disclosure generally relates to compositions and methods for genetic modification of cells. In particular, the disclosure relates to stabilized reagents for genome alteration (e.g., site specific nucleases), as well as stabilized reagents for non-genetic code altering modification (e.g., DNA methylation). Stabilization methods include storage of reagents at suitable temperatures, conversion to dry forms, and chemical modifications.

公开(公告)号：EP3872177A1

公开(公告)日：2021-09-01

申请号：EP20213966.3

申请日：2017-05-25

Applicant: Life Technologies Corporation

Inventor： LIANG, Xiquan ,  POTTER, Robert ,  RAVINDER, Namritha ,  KUMAR, Shantanu

IPC: C12N15/10 ,  C12N15/90

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

公开(公告)号：EP3204513A2

公开(公告)日：2017-08-16

申请号：EP15785207.0

申请日：2015-10-09

Applicant: Life Technologies Corporation ,  Thermo Fisher Scientific GENEART GmbH

Inventor： RAVINDER, Namritha ,  HEIL, Korbinian ,  GUO, Yizhu ,  LIANG, Xiquan ,  POTTER, Robert

IPC: C12Q1/68 ,  C12N15/113 ,  C12N15/10

CPC classification number: C12N15/907 ,  C12N15/102 ,  C12N15/11 ,  C12N2310/3519 ,  C12P19/34 ,  C12Q1/686 ,  C12Q2525/143

Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

Abstract translation: 本公开总体上涉及用于细胞遗传修饰的组合物和方法。 特别地，本公开涉及CRISPR试剂和这些试剂的用途。