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公开(公告)号:US10065186B2
公开(公告)日:2018-09-04
申请号:US14653731
申请日:2013-12-20
Applicant: Micronics, Inc.
Inventor: Andrew Kolb , Isaac Sprague , Justin L. Kay , Matthew Scott Bragd , Martha Stone
IPC: B01L3/00 , F16K99/00 , B81B3/00 , B81C1/00 , B29C43/02 , B29C65/16 , F04B43/04 , B29K101/00 , B29L9/00 , B29L31/00
Abstract: Fluidic cartridges, and manufacture thereof, having a plurality of circuit element subtypes containing pneumatically operated diaphragm members, where the diaphragm materials are selected for yield point, chemical resistance, breathability and other properties individually according to the fluidic element subtype are provided. A process of in-situ edge-bonded decoupage for forming diaphragm members inside a cartridge, and fluidic circuits having diaphragm members as active and passive circuit elements, including pumps, valves, vents, waste receptacles, reagent reservoirs, and cuvettes with optical windows, where the material composition of each individual diaphragm member may be selected from an assortment of materials during manufacture are also provided.
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公开(公告)号:US20150352549A1
公开(公告)日:2015-12-10
申请号:US14653731
申请日:2013-12-20
Applicant: MICRONICS, INC.
Inventor: Andrew Kolb , Isaac Sprague , Justin L. Kay , Matthew Scott Bragd , Martha Stone
CPC classification number: B01L3/50273 , B01L3/502707 , B01L3/502738 , B01L2200/0689 , B01L2200/12 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B29C43/021 , B29C65/16 , B29K2101/00 , B29L2009/00 , B29L2031/7496 , B81B2201/052 , B81C1/00119 , F04B43/043 , F16K99/0015 , F16K99/0059 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , Y10T156/1026
Abstract: Fluidic cartridges, and manufacture thereof, having a plurality of circuit element subtypes containing pneumatically operated diaphragm members, where the diaphragm materials are selected for yield point, chemical resistance, breathability and other properties individually according to the fluidic element subtype are provided. A process of in-situ edge-bonded decoupage for forming diaphragm members inside a cartridge, and fluidic circuits having diaphragm members as active and passive circuit elements, including pumps, valves, vents, waste receptacles, reagent reservoirs, and cuvettes with optical windows, where the material composition of each individual diaphragm member may be selected from an assortment of materials during manufacture are also provided.
Abstract translation: 提供具有包含气动操作的隔膜部件的多个电路元件亚型的流体盒及其制造,其中根据流体元件亚型分别选择隔膜材料用于屈服点,耐化学性,透气性和其它性质。 一种用于在筒内形成膜片构件的原位边缘粘合去耦的过程,以及具有作为主动和被动电路元件的隔膜构件的流体回路,包括泵,阀,通风口,废物容器,试剂储存器和具有光学窗口的比色杯, 其中还提供了每个单独隔膜构件的材料组成可以在制造期间从各种材料中选择。
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公开(公告)号:US20180125464A1
公开(公告)日:2018-05-10
申请号:US15569701
申请日:2016-04-29
Applicant: Micronics, Inc.
Inventor: Andrew Kolb , Alan K. Lofquist , C. Frederick Battrell
CPC classification number: A61B10/0096 , A61B10/0045 , A61B10/02 , B01L3/50825 , B01L2200/026 , B01L2200/027 , B01L2200/16 , B01L2300/043 , B01L2300/044 , B01L2300/0681 , B01L2400/0683 , G01N1/00
Abstract: A specimen collection and delivery apparatus for collecting clinical specimens and delivery of samples thereof to, e.g., microfluidic testing devices for diagnostic analysis is disclosed. The specimen collection and delivery apparatus includes a closure housing for coupling with a sample tube at one end, an open luer for coupling with a complementary luer on a microfluidic device at the other end, and a filter matrix disposed in the interior. The filter matrix is air permeable and liquid impermeable at atmospheric pressure and prevents sample from flowing through the open luer end when coupled to a sample tube containing a specimen. Under vacuum, the liquid sample fraction of the specimen can be drawn through the filter matrix and into the microfluidic testing device through the luer connection for diagnostic analysis.
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公开(公告)号:US20170113221A1
公开(公告)日:2017-04-27
申请号:US15317365
申请日:2015-06-11
Applicant: Micronics, Inc.
Inventor: Danny Hoffman , Asa Bergdahl , Megan Couch , Raf Rivera , Matthew Scott Bragd , Alan K. Lofquist , Andrew Kolb , Justin L. Kay
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/52 , B01L3/527 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0684 , B01L2200/14 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N21/274 , G01N21/6428 , G01N21/6452 , G01N35/00069 , G01N2035/00158
Abstract: Disclosed is a microassay testing system, including a microfluidic cartridge and a compact microprocessor-controlled instrument for fluorometric assays in liquid samples, the cartridge having integrated process controls and positive and negative assay controls. The instrument has a scanning detector head incorporating multiple optical channels. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a process control. Integrated positive and negative assay controls provide enhanced assay validation capabilities and facilitate analysis of test results. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.
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