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    DEVICE AND METHOD FOR ACTIVATING A CAPILLARY-STOP VALVE OF A DEVICE
    1.
    发明申请
    DEVICE AND METHOD FOR ACTIVATING A CAPILLARY-STOP VALVE OF A DEVICE 审中-公开
    用于激活装置的截止阀的装置和方法

    公开(公告)号：WO2014051427A1

    公开(公告)日：2014-04-03

    申请号：PCT/NL2013/050687

    申请日：2013-09-25

    Applicant: MICRONIT MICROFLUIDICS B.V.

    Inventor： VROUWE, Elwin Xander ,  DHINDSA, Manjeet ,  OLDE RIEKERINK, Marinus Bernardus ,  VAN 'T OEVER, Ronny ,  BLOM, Marko Theodoor

    IPC: B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/502738 ,  B01L2200/143 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0688 ,  F16K99/0017 ,  F16K99/0042 ,  F16K2099/0084

    Abstract: The invention relates to a device (20), comprising: • - a liquid container (21) for containing a liquid; • - a capillary-stop valve (22) that is in medium through flow connection with said liquid container (21) for stopping said liquid in said container from flowing out of said container via said capillary- stop valve (22); • - a first electrode (7) being arranged such that in use said first electrode is in contact with said liquid in said liquid container; • - a second electrode (2) that is spaced apart from said capillary- stop valve by an electrically insulating medium gap (24), and • - a voltage source (V) connected to said first and second electrode which is activatable for applying an electric potential difference at the first and second electrode such that the liquid in the liquid container is attracted in the direction of said second electrode so as to allow the liquid to overcome the stopping effect of the capillary- stop valve for discharging liquid from said liquid container via said capillary-stop valve. The invention also relates to a method for activating a capillary-stop valve of a device.

    Abstract translation: 本发明涉及一种装置（20），包括： - 用于容纳液体的液体容器（21）; • - 与所述液体容器（21）处于中等通过流动连接的用于阻止所述容器中的液体经由所述毛细管截止阀（22）从所述容器流出的毛细管截止阀（22）; ·第一电极（7）被布置为使得所述第一电极在所述液体容器中与所述液体接触; - 第二电极（2），其通过电绝缘介质间隙（24）与所述毛细管截止阀间隔开，和 - 连接到所述第一和第二电极的电压源（V），其可激活以施加 在第一和第二电极处的电位差使得液体容器中的液体沿着所述第二电极的方向被吸引，以便液体克服用于从液体容器排出液体的毛细管截止阀的停止效果 通过所述毛细管截止阀。 本发明还涉及用于激活装置的毛细管截止阀的方法。

    METHOD FOR FORMING AN ELECTRICALLY CONDUCTIVE VIA IN A SUBSTRATE
    2.
    发明申请
    METHOD FOR FORMING AN ELECTRICALLY CONDUCTIVE VIA IN A SUBSTRATE 审中-公开
    通过基板形成电导通的方法

    公开(公告)号：WO2014070017A1

    公开(公告)日：2014-05-08

    申请号：PCT/NL2013/050787

    申请日：2013-11-05

    Applicant: MICRONIT MICROFLUIDICS B.V.

    Inventor： VAN'T OEVER, Ronny ,  BLOM, Marko Theodoor ,  HANEVELD, Jeroen ,  OONK, Johannes ,  TIJSSEN, Peter

    IPC: H01L21/48 ,  H01L23/14 ,  H01L21/683

    CPC classification number: H01L21/76879 ,  B81C1/00095 ,  H01L21/486 ,  H01L21/6835 ,  H01L23/147 ,  H01L23/49827 ,  H01L2221/68345 ,  H01L2924/0002 ,  H01L2924/00

    Abstract: The invention relates to a method for forming an electrically conductive via in a substrate and such a substrate comprising an electrically conductive, said method comprising the steps, to be performed in suitable sequence, of: a) providing a first substrate as said substrate; b) forming a through hole in said first substrate; c) providing a second substrate; d) bringing a first surface of said second substrate into contact with said first surface of said first substrate, such that said through hole in said first substrate is covered by said first surface of said second substrate; e) filling said through hole in said first substrate with an electrically conductive material by means of electroplating for forming said electrically conductive via, and f) removing said second substrate, wherein said first surface of said first substrate and said first surface of said second substrate each have a surface roughness R a of less than 2nm, preferably less than 1 nm, more preferably less than 0.5 nm, and in that in step (d) said first surface of said first substrate and said first surface of said second substrate are brought in direct contact with each other, such that a direct bond is formed there between.

    Abstract translation: 本发明涉及一种用于在衬底中形成导电通孔的方法，并且这种衬底包括导电的所述方法，所述方法包括以适当顺序执行的以下步骤：a）提供作为所述衬底的第一衬底; b）在所述第一衬底中形成通孔; c）提供第二衬底; d）使所述第二基板的第一表面与所述第一基板的所述第一表面接触，使得所述第一基板中的所述通孔被所述第二基板的所述第一表面覆盖; e）通过用于形成所述导电通孔的电镀用导电材料填充所述第一衬底中的所述通孔，以及f）去除所述第二衬底，其中所述第一衬底的所述第一表面和所述第二衬底的所述第一表面 每个表面粗糙度R a小于2nm，优选小于1nm，更优选小于0.5nm，并且在步骤（d）中，使所述第一基板的所述第一表面和所述第二基板的所述第一表面带入 彼此直接接触，从而在其间形成直接粘结。

    DEVICE AND METHOD FOR MEASURING A VOLUME OF A LIQUID AND METHOD AND DEVICE FOR CALIBRATING A LIQUID DISPENSING SYSTEM
    3.
    发明申请
    DEVICE AND METHOD FOR MEASURING A VOLUME OF A LIQUID AND METHOD AND DEVICE FOR CALIBRATING A LIQUID DISPENSING SYSTEM 审中-公开
    用于测量液体体积的装置和方法以及用于校准液体分配系统的方法和装置

    公开(公告)号：WO2015099532A1

    公开(公告)日：2015-07-02

    申请号：PCT/NL2014/050905

    申请日：2014-12-24

    Applicant: MICRONIT MICROFLUIDICS B.V.

    Inventor： VAN 'T OEVER, Ronny ,  BLOM, Marko Theodoor ,  NUTMA, Adriaan Johannes ,  BLOK, Herman Jacobus

    IPC: G01F13/00 ,  G01B13/00 ,  G01B11/00 ,  G01N33/49

    CPC classification number: G01F25/0007 ,  G01B13/00 ,  G01F13/00 ,  G01F25/0092

    Abstract: The invention relates to a device for measuring a volume of a liquid, said device comprising: - a receptacle for receiving said liquid, said receptacle comprising an inlet opening and an outlet opening, and - a capillary channel having capillary action, which capillary channel has a predetermined internal transverse cross-section, wherein an inlet opening of the capillary channel at an first end thereof is in liquid through flow connection with the outlet opening of the receptacle and wherein the other, second end of the capillary channel comprises an opening; wherein: - the inlet opening of the receptacle has a larger transverse cross-section than the inlet opening of said capillary channel, and - a length of a liquid slug in the capillary channel is a measure for said volume. The invention further relates to a method for measuring a volume of a liquid using such a device, a method for calibrating a liquid dispensing system using such a device, a calibrating system for calibrating a liquid dispensing system using such a device and a support for supporting a plurality of such devices.

    Abstract translation: 本发明涉及一种用于测量液体体积的装置，所述装置包括： - 容纳所述液体的容器，所述容器包括入口和出口，以及具有毛细管作用的毛细通道，所述毛细通道具有 预定的内部横截面，其中在其第一端处的毛细通道的入口通过与所述容器的出口开口的流动连接处于液体中，并且其中所述毛细通道的另一个第二端包括开口; 其中： - 所述容器的入口开口具有比所述毛细通道的入口更大的横截面，以及 - 所述毛细通道中的液体段的长度是所述体积的量度。 本发明还涉及使用这种装置测量液体体积的方法，使用这种装置校准液体分配系统的方法，使用这种装置校准液体分配系统的校准系统和用于支撑 多个这样的设备。

    METHOD FOR FORMING AN ELECTRICALLY CONDUCTIVE VIA IN A SUBSTRATE
    5.
    发明公开
    METHOD FOR FORMING AN ELECTRICALLY CONDUCTIVE VIA IN A SUBSTRATE 审中-公开
    VERFAHREN ZUR HERSTELLUNG EINES ELEKTRISCH LEITENDEN DURCHGANGS BEI EINEM SUBSTRAT

    公开(公告)号：EP2915188A1

    公开(公告)日：2015-09-09

    申请号：EP13801864.3

    申请日：2013-11-05

    Applicant: Micronit Microfluidics B.V.

    Inventor： VAN'T OEVER, Ronny ,  BLOM, Marko Theodoor ,  HANEVELD, Jeroen ,  OONK, Johannes ,  TIJSSEN, Peter

    IPC: H01L21/48 ,  H01L23/14 ,  H01L21/683

    Abstract: A method for forming an electrically conductive via in a substrate that includes the steps of: forming a through hole in a first substrate; bringing a first surface of a second substrate into contact with the first surface of the first substrate, such that the through hole in the first substrate is covered by the first surface of the second substrate; filling the through hole in the first substrate with an electrically conductive material by electroplating to form the electrically conductive via, and removing the second substrate, wherein the first surface of the first and the second substrate each have a surface roughness Ra of less than 2 nm, preferably less than 1 nm, more preferably less than 0.5 nm, and the first surface of the first and the second substrate are brought in direct contact with each other, such that a direct bond is formed there between.

    Abstract translation: 本发明涉及一种用于在衬底中形成导电通孔的方法，并且这种衬底包括导电的方法，所述方法包括以适当顺序执行的步骤：a）提供作为所述衬底的第一衬底; b）在所述第一衬底中形成通孔; c）提供第二基底; d）使所述第二基板的第一表面与所述第一基板的所述第一表面接触，使得所述第一基板中的所述通孔被所述第二基板的所述第一表面覆盖; e）通过用于形成所述导电通孔的电镀用导电材料填充所述第一衬底中的所述通孔，以及f）去除所述第二衬底，其中所述第一衬底的所述第一表面和所述第二衬底的所述第一表面 每个表面粗糙度R a小于2nm，优选小于1nm，更优选小于0.5nm，并且在步骤（d）中，所述第一衬底的所述第一表面和所述第二衬底的所述第一表面是 导致彼此直接接触，从而在其间形成直接粘结。

    CHANNEL FOR TRAPPING PARTICLES TO BE FED TO SAID CHANNEL WITH A FLUID
    6.
    发明公开
    CHANNEL FOR TRAPPING PARTICLES TO BE FED TO SAID CHANNEL WITH A FLUID 审中-公开
    CHANNEL捕捉颗粒喂养在所述的通道与液体

    公开(公告)号：EP3130401A1

    公开(公告)日：2017-02-15

    申请号：EP16183611.9

    申请日：2016-08-10

    Applicant: Micronit Microfluidics B.V. ,  Janssen Pharmaceutica, N.V. ,  NXP B.V.

    Inventor： BLOM, Marko Theodoor ,  BRIVIO, Monica ,  TANZI, Simone ,  REUVEKAMP, Simon ,  VAN DORST, Bieke ,  STUYVER, Lieven Jozef ,  VAN DER SAR, Elfried

    IPC: B01L3/00

    CPC classification number: G01N33/54313 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54386

    Abstract: The invention relates to a channel for trapping particles to be fed to said channel with a fluid, said channel having a bottom and opposite sidewalls, the sidewalls defining a width of the channel, said channel further comprising:
    - a first channel part;
    - a second channel part in fluid through flow connection with said first channel part and downstream of said first channel part;
    - an elevated structure provided in said channel that divides said channel in said first channel part and said second channel part and for trapping particles in said first channel part;
    - at least one flow gap provided by said elevated structure for providing said fluid through flow connection between the first channel part and the second channel part for allowing, in use, at least some fluid to flow past said elevated structure into said second channel part while trapping said particles in said first channel part;
    wherein said elevated structure is substantially U-shaped and has a base extending substantially between the opposite sidewalls of the channel and two legs extending from the base in an upstream direction, wherein at least part of said U-shaped elevated structure defines at least part of a particle trapping area for trapping the particles to be fed to said channel.
    The invention further relates to a flow cell comprising such a channel. The invention also relates to an assembly comprising such a flow cell and a detection means. The invention also relates to a method for trapping particles in such a channel. And finally, the invention relates to a method for analyzing a sample using such an assembly.

    Abstract translation: 本发明涉及的信道用于捕集颗粒被供给到所述通道与具有底部和相对的侧壁的流体，所述通道，所述侧壁限定所述通道的宽度，所述通道还包括： - 第一信道部分; - 在流体流的第二通道部分通过与所述第一信道部分和所述第一通道部分的下游连接; - 在所述信道提供的那样高架结构分割所述信道在所述第一通道部分和所述第二通道部分和用于在所述第一通道部分捕集颗粒; - 由所述高架结构用于提供所述流体通过第一通道部分和用于允许所述第二通道部分之间的流动连接，在使用中，至少一些流体流经过所述高架结构到所述第二信道的一部分而提供的至少一个流动间隙 所述捕获在所述第一通道部分的颗粒; worin所述高架结构是大致为U形，并且具有基部的通道的相对侧壁和两个腿来在上游方向上从所述基座延伸之间基本上延伸worin所述U形高架结构的至少一部分定义的至少一部分 用于捕集的颗粒的颗粒捕集面积要被馈送到所述通道中。 本发明还涉及到一个流动池，其包括寻求的信道。 因此，本发明涉及在组件包括寻求的流动池和一个检测装置。 因此本发明涉及一种用于在搜索频道捕集颗粒的方法。 最后，本发明涉及一种用于分析使用搜索到组件的样品的方法。

    DEVICE AND METHOD FOR MEASURING A VOLUME OF A LIQUID AND METHOD AND DEVICE FOR CALIBRATING A LIQUID DISPENSING SYSTEM
    9.
    发明公开
    DEVICE AND METHOD FOR MEASURING A VOLUME OF A LIQUID AND METHOD AND DEVICE FOR CALIBRATING A LIQUID DISPENSING SYSTEM 审中-公开
    设备和方法测量液体数量和方法及装置校准液供给系统

    公开(公告)号：EP3087354A1

    公开(公告)日：2016-11-02

    申请号：EP14828351.8

    申请日：2014-12-24

    Applicant: Micronit Microfluidics B.V.

    Inventor： VAN 'T OEVER, Ronny ,  BLOM, Marko Theodoor ,  NUTMA, Adriaan Johannes ,  BLOK, Herman Jacobus

    IPC: G01F13/00 ,  G01B13/00 ,  G01B11/00 ,  G01N33/49

    CPC classification number: G01F25/0007 ,  G01B13/00 ,  G01F13/00 ,  G01F25/0092

    Abstract: The invention relates to a device for measuring a volume of a liquid, said device comprising: - a receptacle for receiving said liquid, said receptacle comprising an inlet opening and an outlet opening, and - a capillary channel having capillary action, which capillary channel has a predetermined internal transverse cross-section, wherein an inlet opening of the capillary channel at an first end thereof is in liquid through flow connection with the outlet opening of the receptacle and wherein the other, second end of the capillary channel comprises an opening; wherein: - the inlet opening of the receptacle has a larger transverse cross-section than the inlet opening of said capillary channel, and - a length of a liquid slug in the capillary channel is a measure for said volume. The invention further relates to a method for measuring a volume of a liquid using such a device, a method for calibrating a liquid dispensing system using such a device, a calibrating system for calibrating a liquid dispensing system using such a device and a support for supporting a plurality of such devices.

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