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公开(公告)号：CA2974241A1
公开(公告)日：2010-03-25
申请号：CA2974241
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/17 , B82Y20/00 , C12M1/34 , C12Q1/00 , C12Q1/68 , G01N21/00 , G01N21/63 , G01N21/77 , G02B6/12
Abstract: This specification provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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公开(公告)号：AU2009292629B2
公开(公告)日：2014-03-20
申请号：AU2009292629
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/00 , G01B9/02 , G01N33/483
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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公开(公告)号：CA3063032A1
公开(公告)日：2010-03-25
申请号：CA3063032
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
Abstract: The present invention provides an integrated optical device (2300), comprising:a) a first component (2302) comprising a waveguide (2312) disposed upon or within a substrate and a plurality of nanometer-scale apertures (2308) comprising analyte regions (2310), wherein the analyte regions (2310) are disposed sufficiently proximal to a core of the waveguide (2312) to be illuminated by an evanescent field emanating from the core when optical energy is passed through the waveguide;b) a second component (2304) comprising a microlens array that collects optical energy signals from the analyte regions (2310) and directs the optical energy signals so collected to a detector (2320); andc) a third component (2306) comprising the detector (2320).
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公开(公告)号：WO2010033193A3
公开(公告)日：2010-06-10
申请号：PCT/US2009005168
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/00 , G01B9/02 , G01N33/483
CPC classification number: C12Q1/6874 , C12Q1/68 , C12Q1/6825 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6463 , G01N2201/06113 , G01N2201/0638 , G01N2201/08
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
Abstract translation: 本发明提供用于各种应用的底物，包括单分子分析反应。 提供了在基板内传播光能的方法。 提供了包括波导基板和电介质全向反射器的装置。 提供了在阵列的分析检测区域内改善一个或多个波导上的光能强度的均匀性以及增强的波导照明效率的波导基板。
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公开(公告)号：CA2974241C
公开(公告)日：2020-01-07
申请号：CA2974241
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
Abstract: This specification provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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Patent Agency Ranking
公开(公告)号：CA2737505A1
公开(公告)日：2010-03-25
申请号：CA2737505
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/00 , G01B9/02 , G01N33/483
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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公开(公告)号：CA2737505C
公开(公告)日：2017-08-29
申请号：CA2737505
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/00 , G01B9/02 , G01N33/483
Abstract: This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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公开(公告)号：AU2014203354B2
公开(公告)日：2016-06-30
申请号：AU2014203354
申请日：2014-06-20
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/00 , G01B9/02 , G01N33/483
Abstract: This invention provides substrates for use in various applications, including single molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided. ocdq N"t c 00 (Suonlw)o . o
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公开(公告)号：AU2014203354A1
公开(公告)日：2014-07-10
申请号：AU2014203354
申请日：2014-06-20
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/00 , G01B9/02 , G01N33/483
Abstract: This invention provides substrates for use in various applications, including single molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided. ocdq N"t c 00 (Suonlw)o . o
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公开(公告)号：AU2009292629A1
公开(公告)日：2010-03-25
申请号：AU2009292629
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/00 , G01B9/02 , G01N33/483
Abstract: The present invention provides an integrated optical device (2300), comprising:a) a first component (2302) comprising a waveguide (2312) disposed upon or within a substrate and a plurality of nanometer-scale apertures (2308) comprising analyte regions (2310), wherein the analyte regions (2310) are disposed sufficiently proximal to a core of the waveguide (2312) to be illuminated by an evanescent field emanating from the core when optical energy is passed through the waveguide;b) a second component (2304) comprising a microlens array that collects optical energy signals from the analyte regions (2310) and directs the optical energy signals so collected to a detector (2320); andc) a third component (2306) comprising the detector (2320).
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