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    HIGHLY MULTIPLEXED CONFOCAL DETECTION SYSTEMS AND METHODS OF USING SAME
    2.
    发明申请
    HIGHLY MULTIPLEXED CONFOCAL DETECTION SYSTEMS AND METHODS OF USING SAME 审中-公开
    高度多元化的协同检测系统及其使用方法

    公开(公告)号：WO2009038668A3

    公开(公告)日：2009-05-22

    申请号：PCT/US2008010652

    申请日：2008-09-12

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA ,  LUNDQUIST PAUL ,  ZHONG CHENG FRANK ,  ZHAO PEGIAN ,  TURNER STEPHEN

    Inventor： LUNDQUIST PAUL ,  ZHONG CHENG FRANK ,  ZHAO PEGIAN ,  TURNER STEPHEN

    IPC: G01N21/64

    CPC classification number: G01N27/44721

    Abstract: Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high density optical systems to illuminate high density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.

    Abstract translation: 用于使用高度多路复用的高密度光学系统来分析高度多路复用的样本阵列以照射高密度样本阵列和/或提供从这样的高密度阵列发出的检测并且优选地共焦检测关闭信号的系统和方法。 系统和方法应用于各种不同的分析操作，包括生物和生物化学反应的分析，包括核酸合成和从这种合成得到的序列信息。

    SUBSTRATES AND OPTICAL SYSTEMS AND METHODS OF USE THEREOF
    4.
    发明专利
    SUBSTRATES AND OPTICAL SYSTEMS AND METHODS OF USE THEREOF 未知

    公开(公告)号：CA3063032A1

    公开(公告)日：2010-03-25

    申请号：CA3063032

    申请日：2009-09-15

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： ZHONG CHENG FRANK ,  LUNDQUIST PAUL ,  FOQUET MATHIEU ,  KORLACH JONAS ,  BAYANDORIAN HOVIG

    Abstract: The present invention provides an integrated optical device (2300), comprising:a) a first component (2302) comprising a waveguide (2312) disposed upon or within a substrate and a plurality of nanometer-scale apertures (2308) comprising analyte regions (2310), wherein the analyte regions (2310) are disposed sufficiently proximal to a core of the waveguide (2312) to be illuminated by an evanescent field emanating from the core when optical energy is passed through the waveguide;b) a second component (2304) comprising a microlens array that collects optical energy signals from the analyte regions (2310) and directs the optical energy signals so collected to a detector (2320); andc) a third component (2306) comprising the detector (2320).

    Substrates and optical systems and methods of use thereof
    9.
    发明专利
    Substrates and optical systems and methods of use thereof 未知

    公开(公告)号：AU2009292629A1

    公开(公告)日：2010-03-25

    申请号：AU2009292629

    申请日：2009-09-15

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA

    Inventor： ZHONG CHENG FRANK ,  LUNDQUIST PAUL ,  FOQUET MATHIEU ,  KORLACH JONAS ,  BAYANDORIAN HOVIG

    IPC: G01N21/00 ,  G01B9/02 ,  G01N33/483

    Abstract: The present invention provides an integrated optical device (2300), comprising:a) a first component (2302) comprising a waveguide (2312) disposed upon or within a substrate and a plurality of nanometer-scale apertures (2308) comprising analyte regions (2310), wherein the analyte regions (2310) are disposed sufficiently proximal to a core of the waveguide (2312) to be illuminated by an evanescent field emanating from the core when optical energy is passed through the waveguide;b) a second component (2304) comprising a microlens array that collects optical energy signals from the analyte regions (2310) and directs the optical energy signals so collected to a detector (2320); andc) a third component (2306) comprising the detector (2320).

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