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公开(公告)号：CA2959518A1
公开(公告)日：2016-03-03
申请号：CA2959518
申请日：2015-08-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： GROT ANNETTE , SAXENA RAVI , LUNDQUIST PAUL
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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公开(公告)号：AU2009300369A1
公开(公告)日：2010-04-08
申请号：AU2009300369
申请日：2009-09-25
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： ZACCARIN DENIS , LUNDQUIST PAUL , ZHAO PEIQIAN , ZHONG FRANK , TURNER STEPHEN , HUANG YANQIAO , MONADGEMI PEZHMAN , SAXENA RAVI , GROT ANNETTE , RULISON AARON
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公开(公告)号：AU2021222009A1
公开(公告)日：2022-09-15
申请号：AU2021222009
申请日：2021-02-18
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： KURITSYN ALEXEY , MCDONALD MARK , RULISON AARON , GROT ANNETTE
Abstract: Provided herein are highly multiplexed optical analytical systems for improved nucleic acid sequencing. The systems include a plurality of highly multiplexed optical chips, at least one optical source, and a plurality of optical delivery devices for illuminating an array of nanoscale rection regions on each of the optical chips. In use, the reaction regions contain fluorescent nucleic acid sequencing reagents and are arranged to report nucleic acid sequence information to optical detectors associated with the multiplexed optical chips in real time. The systems enable a massive increase in the scale of nucleic acid sequencing reactions capable of being performed within a single instrument without a corresponding increase in size, complexity, or cost of the instrument.
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公开(公告)号：AU2015306603B2
公开(公告)日：2021-04-01
申请号：AU2015306603
申请日：2015-08-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： GROT ANNETTE , SAXENA RAVI , LUNDQUIST PAUL
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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公开(公告)号：AU2015306603A2
公开(公告)日：2017-06-01
申请号：AU2015306603
申请日：2015-08-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： GROT ANNETTE , SAXENA RAVI , LUNDQUIST PAUL
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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Patent Agency Ranking
公开(公告)号：AU2015306603A1
公开(公告)日：2017-04-13
申请号：AU2015306603
申请日：2015-08-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： GROT ANNETTE , SAXENA RAVI , LUNDQUIST PAUL
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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公开(公告)号：CA2738626C
公开(公告)日：2017-08-08
申请号：CA2738626
申请日：2009-09-25
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZACCARIN DENIS , LUNDQUIST PAUL , ZHAO PEIQIAN , ZHONG FRANK , TURNER STEPHEN , HUANG YANQIAO , MONADGEMI PEZHMAN , SAXENA RAVI , GROT ANNETTE , RULISON AARON
Abstract: Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
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公开(公告)号：AU2009300369B2
公开(公告)日：2014-08-14
申请号：AU2009300369
申请日：2009-09-25
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZACCARIN DENIS , LUNDQUIST PAUL , ZHAO PEIQIAN , ZHONG FRANK , TURNER STEPHEN , HUANG YANQIAO , MONADGEMI PEZHMAN , SAXENA RAVI , GROT ANNETTE , RULISON AARON
Abstract: Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
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公开(公告)号：WO2011031313A2
公开(公告)日：2011-03-17
申请号：PCT/US2010002458
申请日：2010-09-08
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , GREY JEREMY , CICERO RONALD , GROT ANNETTE , POPOVICH NATASHA , DUDEK STEPHEN
Inventor： GREY JEREMY , CICERO RONALD , GROT ANNETTE , POPOVICH NATASHA , DUDEK STEPHEN
CPC classification number: G02B6/107 , C23F1/00 , C23F17/00 , C25D11/022 , C25D11/04 , G01N21/6452 , G01N21/7743 , G02B6/10 , G02B6/136
Abstract: The application relates to improved optical containment structures, methods of manufacture and use, and systems for employing same. The optical containment structures generally comprise zero-mode waveguide structures having non-reflective walls. The non-reflective walls allow the preparation of optical containment regions in which the optical containment dimensions can be decoupled from the solution containment dimensions. The application also relates to methods for producing islands of functionality within nanoscale apertures.
Abstract translation: 本申请涉及改进的光学容纳结构，制造和使用方法以及使用它们的系统。 光学容纳结构通常包括具有非反射壁的零模式波导结构。 非反射壁允许制备光学容纳区域，其中光学容纳尺寸可以与溶液容纳尺寸分离。 该应用还涉及在纳米尺度孔内产生功能岛的方法。
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公开(公告)号：EP2936222A4
公开(公告)日：2016-09-07
申请号：EP13863794
申请日：2013-12-16
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： GROT ANNETTE , WANG SHANG , CALLEBAUT HANS , LUNDQUIST PAUL , TURNER STEPHEN
IPC: G01N21/64 , B82Y5/00 , B82Y15/00 , B82Y20/00 , G01N21/77 , G01N33/543 , G01N33/553 , G02B6/10
CPC classification number: G02B6/0016 , B82Y15/00 , B82Y20/00 , G01N21/6452 , G01N21/648 , G01N21/6486 , G01N21/7703 , G02B6/024 , G02B6/10 , G02B6/12004 , G02B6/122 , G02B23/2461
Abstract: Optical analytical devices and their methods of use are provided. The devices are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices include optical waveguides for illumination of the optical reactions. The devices further provide for the efficient coupling of optical excitation energy from the waveguides to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices of the invention are well suited for miniaturization and high throughput.
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