公开(公告)号：EP2782580A4

公开(公告)日：2015-10-07

申请号：EP12851734

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  KANE BRIAN ,  XU QING ,  BAUER SHAWN M ,  SONG YONGHONG ,  PANDEY ANJALI ,  DICK RYAN

IPC: A61K31/506 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07H13/12

CPC classification number: C07H15/26 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07H13/12

公开(公告)号：CA2856306A1

公开(公告)日：2013-05-30

申请号：CA2856306

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  KANE BRIAN ,  XU QING ,  BAUER SHAWN M ,  SONG YONGHONG ,  PANDEY ANJALI ,  DICK RYAN

IPC: C07D403/12 ,  A61K31/505 ,  A61K31/506 ,  A61K31/7064 ,  C07D239/48 ,  C07D239/50 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04 ,  C07H13/12 ,  C12N9/12

Abstract: Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.