公开(公告)号：DE3884672T2

公开(公告)日：1994-04-28

申请号：DE3884672

申请日：1988-02-16

Applicant: SCLAVO SPA

Inventor： NENCIONI LUCIANO ,  ANTONI GUIDO ,  BORASCHI DIANA ,  TAGLIABUE ALDO

IPC: A61K38/00 ,  A61K39/39 ,  A61P37/04 ,  C07K14/545 ,  A61K37/02

Abstract: The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-dependent and thymo-independent antigens having low immunogenicity. Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.

公开(公告)号：AT63749T

公开(公告)日：1991-06-15

申请号：AT86830299

申请日：1986-10-17

Applicant: SCLAVO SPA

Inventor： TAGLIABUE ALDO ,  BORASCHI DIANA ,  ANTONI GUIDO ,  PRESENTINI RIVO

IPC: C07K14/52 ,  A61K38/00 ,  A61K39/39 ,  A61P37/00 ,  C07K7/06 ,  C07K14/54 ,  C07K14/545 ,  A61K37/02

Abstract: Synthetic peptide with human interleukin 1 acti­vity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula:    Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X      (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.

公开(公告)号：ES2044841T3

公开(公告)日：1994-01-16

申请号：ES86830299

申请日：1986-10-17

Applicant: SCLAVO SPA

Inventor： TAGLIABUE ALDO ,  BORASCHI DIANA ,  ANTONI GUIDO ,  PRESENTINI RIVO

IPC: C07K14/52 ,  A61K38/00 ,  A61K39/39 ,  A61P37/00 ,  C07K7/06 ,  C07K14/54 ,  C07K14/545 ,  A61K37/02

Abstract: Synthetic peptide with human interleukin 1 acti­vity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula:    Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X      (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.

公开(公告)号：IT8719434D0

公开(公告)日：1987-02-20

申请号：IT1943487

申请日：1987-02-20

Applicant: SCLAVO SPA

Inventor： NENCIONI LUCIANO ,  ANTONI GUIDO ,  BORASCHI DIANA ,  TAGLIABUE ALDO

IPC: A61K38/00 ,  A61K39/39 ,  A61P37/04 ,  C07K14/545

Abstract: The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-dependent and thymo-independent antigens having low immunogenicity. Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.

公开(公告)号：IT8619338D0

公开(公告)日：1986-02-07

申请号：IT1933886

申请日：1986-02-07

Applicant: SCLAVO SPA

Inventor： TAGLIABUE ALDO ,  ANTONI GUIDO ,  BORASCHI RIVO PRESENTINI DIAN

IPC: A61K38/00 ,  C07K14/52 ,  A61K39/39 ,  A61P37/00 ,  C07K7/06 ,  C07K14/54 ,  C07K14/545 ,  A61K

Abstract: Synthetic peptide with human interleukin 1 acti­vity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula:    Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X      (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.

公开(公告)号：ES2059562T3

公开(公告)日：1994-11-16

申请号：ES88830056

申请日：1988-02-16

Applicant: SCLAVO SPA

Inventor： NENCIONI LUCIANO ,  ANTONI GUIDO ,  BORASCHI DIANA ,  TAGLIABUE ALDO

IPC: A61K38/00 ,  A61K39/39 ,  A61P37/04 ,  C07K14/545 ,  A61K37/02

Abstract: The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-dependent and thymo-independent antigens having low immunogenicity. Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.

公开(公告)号：DE3884672D1

公开(公告)日：1993-11-11

申请号：DE3884672

申请日：1988-02-16

Applicant: SCLAVO SPA

Inventor： NENCIONI LUCIANO ,  ANTONI GUIDO ,  BORASCHI DIANA ,  TAGLIABUE ALDO

IPC: A61K38/00 ,  A61K39/39 ,  A61P37/04 ,  C07K14/545 ,  A61K37/02

Abstract: The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-dependent and thymo-independent antigens having low immunogenicity. Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.

公开(公告)号：IT1188550B

公开(公告)日：1988-01-14

申请号：IT1933886

申请日：1986-02-07

Applicant: SCLAVO SPA

Inventor： TAGLIABUE ALDO ,  ANTONI GUIDO ,  PRESENTINI RIVO ,  BORASCHI DIAN

IPC: A61K38/00 ,  C07K14/52 ,  A61K39/39 ,  A61P37/00 ,  C07K7/06 ,  C07K14/54 ,  C07K14/545 ,  A61K

Abstract: Synthetic peptide with human interleukin 1 acti­vity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula:    Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X      (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.

公开(公告)号：AT95422T

公开(公告)日：1993-10-15

申请号：AT88830056

申请日：1988-02-16

Applicant: SCLAVO SPA

Inventor： NENCIONI LUCIANO ,  ANTONI GUIDO ,  BORASCHI DIANA ,  TAGLIABUE ALDO

IPC: A61K38/00 ,  A61K39/39 ,  A61P37/04 ,  C07K14/545 ,  A61K37/02

Abstract: The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-dependent and thymo-independent antigens having low immunogenicity. Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.

公开(公告)号：GR3002597T3

公开(公告)日：1993-01-25

申请号：GR910401226

申请日：1991-08-22

Applicant: SCLAVO SPA

Inventor： TAGLIABUE ALDO ,  BORASCHI DIANA ,  ANTONI GUIDO ,  PRESENTINI RIVO

IPC: A61K38/00 ,  A61K39/39 ,  C07K14/52 ,  A61P37/00 ,  C07K7/06 ,  C07K14/54 ,  C07K14/545 ,  A61K37/02

Abstract: Synthetic peptide with human interleukin 1 acti­vity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula:    Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X      (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.