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公开(公告)号:DE3884672T2
公开(公告)日:1994-04-28
申请号:DE3884672
申请日:1988-02-16
Applicant: SCLAVO SPA
Inventor: NENCIONI LUCIANO , ANTONI GUIDO , BORASCHI DIANA , TAGLIABUE ALDO
IPC: A61K38/00 , A61K39/39 , A61P37/04 , C07K14/545 , A61K37/02
Abstract: The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-dependent and thymo-independent antigens having low immunogenicity. Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.
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公开(公告)号:DE3880625D1
公开(公告)日:1993-06-03
申请号:DE3880625
申请日:1988-10-31
Applicant: SCLAVO SPA
Inventor: GHIARA PAOLO , VILLA LUIGI , NENCIONI LUCIANO , TAGLIABUE ALDO , BORASCHI DIANA
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公开(公告)号:AT63749T
公开(公告)日:1991-06-15
申请号:AT86830299
申请日:1986-10-17
Applicant: SCLAVO SPA
Inventor: TAGLIABUE ALDO , BORASCHI DIANA , ANTONI GUIDO , PRESENTINI RIVO
Abstract: Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
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公开(公告)号:AT95422T
公开(公告)日:1993-10-15
申请号:AT88830056
申请日:1988-02-16
Applicant: SCLAVO SPA
Inventor: NENCIONI LUCIANO , ANTONI GUIDO , BORASCHI DIANA , TAGLIABUE ALDO
IPC: A61K38/00 , A61K39/39 , A61P37/04 , C07K14/545 , A61K37/02
Abstract: The specification relates to a synthetic peptide converted into a salt comprising one or more amine groups and capable of potentiating in vivo the primary and secondary antibody response to thymo-dependent and thymo-independent antigens having low immunogenicity. Injectable preparations comprising a solution of the peptide in a pharmacologically acceptable solvent are particularly useful as adjuvants in therapy.
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公开(公告)号:DE3880625T2
公开(公告)日:1993-08-12
申请号:DE3880625
申请日:1988-10-31
Applicant: SCLAVO SPA
Inventor: GHIARA PAOLO , VILLA LUIGI , NENCIONI LUCIANO , TAGLIABUE ALDO , BORASCHI DIANA
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公开(公告)号:GR3002597T3
公开(公告)日:1993-01-25
申请号:GR910401226
申请日:1991-08-22
Applicant: SCLAVO SPA
Inventor: TAGLIABUE ALDO , BORASCHI DIANA , ANTONI GUIDO , PRESENTINI RIVO
Abstract: Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
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公开(公告)号:IT1229766B
公开(公告)日:1991-09-10
申请号:IT2055489
申请日:1989-05-19
Applicant: SCLAVO SPA
Inventor: MAGISTRIS MARIA TERESA DE , BARTOLONI ANTONELLA , RAPPUOLI RINO , TAGLIABUE ALDO
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公开(公告)号:DE3679396D1
公开(公告)日:1991-06-27
申请号:DE3679396
申请日:1986-10-17
Applicant: SCLAVO SPA
Inventor: TAGLIABUE ALDO , BORASCHI DIANA , ANTONI GUIDO , PRESENTINI RIVO
Abstract: Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
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公开(公告)号:IT1223339B
公开(公告)日:1990-09-19
申请号:IT2248687
申请日:1987-11-02
Applicant: SCLAVO SPA
Inventor: GHIARA PAOLO , VILLA LUIGI , NENCIONI LUCIANO , TAGLIABUE ALDO , BORASCHI DIANA
Abstract: The use of Oncogen Necrosis Factor (ONF) for prepg. a compsn. (I) for potentiating the primary and secondary immune response against natural or synthetic antigens in a living organism. (I) pref. contains a solvent (e.g. saline serum, phosphate buffer and/or water) and 0.013 pg/kg - 8 g/kg of ONF. It may also include a therapeutically effective amt. of a natural or synthetic antigen (alone or on a macromolecular support). (I) may be administered i.v., i.m. or i.p.
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公开(公告)号:IT8920554D0
公开(公告)日:1989-05-19
申请号:IT2055489
申请日:1989-05-19
Applicant: SCLAVO SPA
Inventor: MAGISTRIS MARIA TERESA DE , BARTOLONI ANTONELLA , RAPPUOLI RINO , TAGLIABUE ALDO
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