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公开(公告)号：IT8922251A1
公开(公告)日：1991-05-03
申请号：IT2225189
申请日：1989-11-03
Applicant: SCLAVO SPA
Inventor： PERRETTI MAURO , BECHERUCCI CRISTINA , MUGRIDGE KENNETH GORDON , SOLITO EGLE , PRESENTINI RIVO , PARENTE LUCA
IPC: C07C20060101 , A61K20060101
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公开(公告)号：ES2044841T3
公开(公告)日：1994-01-16
申请号：ES86830299
申请日：1986-10-17
Applicant: SCLAVO SPA
Inventor： TAGLIABUE ALDO , BORASCHI DIANA , ANTONI GUIDO , PRESENTINI RIVO
Abstract: Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
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公开(公告)号：GR3002597T3
公开(公告)日：1993-01-25
申请号：GR910401226
申请日：1991-08-22
Applicant: SCLAVO SPA
Inventor： TAGLIABUE ALDO , BORASCHI DIANA , ANTONI GUIDO , PRESENTINI RIVO
Abstract: Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
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公开(公告)号：DE3679396D1
公开(公告)日：1991-06-27
申请号：DE3679396
申请日：1986-10-17
Applicant: SCLAVO SPA
Inventor： TAGLIABUE ALDO , BORASCHI DIANA , ANTONI GUIDO , PRESENTINI RIVO
Abstract: Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
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公开(公告)号：ITFI920146A1
公开(公告)日：1994-01-18
申请号：ITFI920146
申请日：1992-07-17
Applicant: SCLAVO SPA
Inventor： PRESENTINI RIVO , TERRANA BENEDETTO
IPC: C08G20060101 , C12N9/08 , G01N33/531 , G01N33/535 , G01N33/543
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Patent Agency Ranking
公开(公告)号：CA2034618A1
公开(公告)日：1992-07-22
申请号：CA2034618
申请日：1991-01-21
Applicant: SCLAVO SPA
Inventor： PERRETTI MAURO , BECHERUCCI CRISTINA , MUGRIDGE KENNETH G , SOLITO EGLE , PRESENTINI RIVO , PARENTE LUCA
Abstract: SYNTHETIC PEPTIDE DERIVED FROM HUMAN LIPOCORTIN V AND USE THEREOF The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val- Phe-Asp-Lys-OH and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. Said peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.
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公开(公告)号：AT63749T
公开(公告)日：1991-06-15
申请号：AT86830299
申请日：1986-10-17
Applicant: SCLAVO SPA
Inventor： TAGLIABUE ALDO , BORASCHI DIANA , ANTONI GUIDO , PRESENTINI RIVO
Abstract: Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
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公开(公告)号：IT8922251D0
公开(公告)日：1989-11-03
申请号：IT2225189
申请日：1989-11-03
Applicant: SCLAVO SPA
Inventor： PERRETTI MAURO , BECHERUCCI CRISTINA , MUGRIDGE KENNETH GORDON , SOLITO EGLE , PRESENTINI RIVO , PARENTE LUCA
IPC: A61K20060101 , C07C20060101 , C07C , A61K
Abstract: The synthetic peptide with the formula (I): H-Ser-His-Leu-Arg-Lys-Val-Phe-Asp-Lys-OH and its organic or inorganic salts physiologically acceptably are new. The synthetic peptide (I), whose amino acid sequence corresponds to that of segment 204-212 of the human lipcortin V, shows in in-vitro conditions the ability to inhibit the release of E2 prostaglandin and in live conditions has an anti-inflammatory effect. Said peptide (I) and its organic and inorganic salts are used as therapeutic reactants in treating inflammatory, dermatological and collagen infections.
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公开(公告)号：ITFI920146D0
公开(公告)日：1992-07-17
申请号：ITFI920146
申请日：1992-07-17
Applicant: SCLAVO SPA
Inventor： PRESENTINI RIVO , TERRANA BENEDETTO
IPC: C12N9/08 , G01N33/531 , G01N33/535 , G01N33/543
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公开(公告)号：IT1188550B
公开(公告)日：1988-01-14
申请号：IT1933886
申请日：1986-02-07
Applicant: SCLAVO SPA
Inventor： TAGLIABUE ALDO , ANTONI GUIDO , PRESENTINI RIVO , BORASCHI DIAN
Abstract: Synthetic peptide with human interleukin 1 activity, which peptide can be used as a stimulant of the immune functions and can be defined by the general formula: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-X (I)where:Val = L-valine; Gln = L-glutamine; Gly = glycine; Glu = L-glutamic acid; Ser = L-serine; Asn = L-asparagine; Asp = L-aspartic acid; Lys = L-lysine; X = cysteine (Cys), OH, NH₂, a benzyl ester or an alkyl ester group having a number of carbon atoms from 1 to 7.
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