公开(公告)号：CA2034618A1

公开(公告)日：1992-07-22

申请号：CA2034618

申请日：1991-01-21

Applicant: SCLAVO SPA

Inventor： PERRETTI MAURO ,  BECHERUCCI CRISTINA ,  MUGRIDGE KENNETH G ,  SOLITO EGLE ,  PRESENTINI RIVO ,  PARENTE LUCA

IPC: A61K38/08 ,  A61P29/00 ,  C07K7/06

Abstract: SYNTHETIC PEPTIDE DERIVED FROM HUMAN LIPOCORTIN V AND USE THEREOF The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val- Phe-Asp-Lys-OH and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. Said peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.

公开(公告)号：CA2034520A1

公开(公告)日：1991-07-20

申请号：CA2034520

申请日：1991-01-18

Applicant: SCLAVO SPA

Inventor： PARENTE LUCA ,  MUGRIDGE KENNETH G ,  WALLACE JOHN ,  KEENAN CATHERINE

IPC: A61K38/00 ,  A61K31/60 ,  A61K38/20 ,  A61P1/04

Abstract: NEW PHARMACEUTICAL COMPOSITION FOR PROTECTING THE GASTRODUODENAL MUCOSA The use of human interleukin-1.beta. as gastroduodenal mucosa protector for treating gastroduodenal, benign, recurring and post-operational ulcers is described, together with pharmaceutical compositions containing a therapeutically effective quantity of human interleukin-1.beta..