公开(公告)号：IT1236970B

公开(公告)日：1993-05-07

申请号：IT2225189

申请日：1989-11-03

Applicant: SCLAVO SPA

Inventor： PERRETTI MAURO ,  BECHERUCCI CRISTINA ,  PARENTE LUCA

IPC: A61K20060101 ,  C07C20060101 ,  C07C ,  A61K

Abstract: The synthetic peptide with the formula (I): H-Ser-His-Leu-Arg-Lys-Val-Phe-Asp-Lys-OH and its organic or inorganic salts physiologically acceptably are new. The synthetic peptide (I), whose amino acid sequence corresponds to that of segment 204-212 of the human lipcortin V, shows in in-vitro conditions the ability to inhibit the release of E2 prostaglandin and in live conditions has an anti-inflammatory effect. Said peptide (I) and its organic and inorganic salts are used as therapeutic reactants in treating inflammatory, dermatological and collagen infections.

公开(公告)号：IT8922791A1

公开(公告)日：1991-06-21

申请号：IT2279189

申请日：1989-12-21

Applicant: SCLAVO SPA

Inventor： PERRETTI MAURO ,  BECHERUCCI CRISTINA ,  PARENTE LUCA ,  SILVESTRI SERGIO

IPC: A61K20060101 ,  A61K38/00 ,  A61K38/07 ,  A61P29/00 ,  C07K5/10

公开(公告)号：IT1238070B

公开(公告)日：1993-07-03

申请号：IT1911090

申请日：1990-01-19

Applicant: SCLAVO SPA

Inventor： PARENTE LUCA

IPC: A61K38/00 ,  A61K31/60 ,  A61K38/20 ,  A61P1/04 ,  A61K

公开(公告)号：CA2034618A1

公开(公告)日：1992-07-22

申请号：CA2034618

申请日：1991-01-21

Applicant: SCLAVO SPA

Inventor： PERRETTI MAURO ,  BECHERUCCI CRISTINA ,  MUGRIDGE KENNETH G ,  SOLITO EGLE ,  PRESENTINI RIVO ,  PARENTE LUCA

IPC: A61K38/08 ,  A61P29/00 ,  C07K7/06

Abstract: SYNTHETIC PEPTIDE DERIVED FROM HUMAN LIPOCORTIN V AND USE THEREOF The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val- Phe-Asp-Lys-OH and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. Said peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.

公开(公告)号：CA2034520A1

公开(公告)日：1991-07-20

申请号：CA2034520

申请日：1991-01-18

Applicant: SCLAVO SPA

Inventor： PARENTE LUCA ,  MUGRIDGE KENNETH G ,  WALLACE JOHN ,  KEENAN CATHERINE

IPC: A61K38/00 ,  A61K31/60 ,  A61K38/20 ,  A61P1/04

Abstract: NEW PHARMACEUTICAL COMPOSITION FOR PROTECTING THE GASTRODUODENAL MUCOSA The use of human interleukin-1.beta. as gastroduodenal mucosa protector for treating gastroduodenal, benign, recurring and post-operational ulcers is described, together with pharmaceutical compositions containing a therapeutically effective quantity of human interleukin-1.beta..

公开(公告)号：CA2030005A1

公开(公告)日：1991-06-22

申请号：CA2030005

申请日：1990-11-14

Applicant: SCLAVO SPA

Inventor： BECHERUCCI CRISTINA ,  PERRETTI MAURO ,  SILVERSTRI SERGIO ,  PARENTE LUCA

IPC: A61K38/00 ,  A61K38/07 ,  A61P29/00 ,  C07K5/10 ,  C07K5/062 ,  A61K38/05 ,  C07K5/103

Abstract: NEW PHARMACEUTICAL COMPOSITION WITH ANTI-INFLAMMATORY ACTIVITY OF THE DISCLOSURE The use of natural tuftsin (I) and retro-inverted tuftsin (II) or a pharmaceutically acceptable salt of basic or acid addition thereof as anti-inflammatory agents for the treatment of illnesses of inflammatory pathogenesis is described, together with pharmaceutical compositions comprising a therapeutically effective quantity of compound (I) or (II) or of their salts of addition.

公开(公告)号：IT8922791D0

公开(公告)日：1989-12-21

申请号：IT2279189

申请日：1989-12-21

Applicant: SCLAVO SPA

Inventor： BECHERUCCI CRISTINA ,  PERRETTI MAURO ,  SILVESTRI SERGIO ,  PARENTE LUCA

IPC: A61K38/07 ,  A61K38/00 ,  A61P29/00 ,  C07K5/10 ,  A61K

Abstract: The use of natural tuftsin (I) and retro-inverted tuftsin (II) or a pharmaceutically acceptable salt of basic or acid addition thereof as anti-inflammatory agents for the treatment of illnesses of inflammatory pathogenesis is described, together with pharmaceutical compositions comprising a therapeutically effective quantity of compound (I) or (II) or of their salts of addition.

公开(公告)号：IT8922251D0

公开(公告)日：1989-11-03

申请号：IT2225189

申请日：1989-11-03

Applicant: SCLAVO SPA

Inventor： PERRETTI MAURO ,  BECHERUCCI CRISTINA ,  MUGRIDGE KENNETH GORDON ,  SOLITO EGLE ,  PRESENTINI RIVO ,  PARENTE LUCA

IPC: A61K20060101 ,  C07C20060101 ,  C07C ,  A61K

Abstract: The synthetic peptide with the formula (I): H-Ser-His-Leu-Arg-Lys-Val-Phe-Asp-Lys-OH and its organic or inorganic salts physiologically acceptably are new. The synthetic peptide (I), whose amino acid sequence corresponds to that of segment 204-212 of the human lipcortin V, shows in in-vitro conditions the ability to inhibit the release of E2 prostaglandin and in live conditions has an anti-inflammatory effect. Said peptide (I) and its organic and inorganic salts are used as therapeutic reactants in treating inflammatory, dermatological and collagen infections.

公开(公告)号：IT1239477B

公开(公告)日：1993-11-02

申请号：IT2279189

申请日：1989-12-21

Applicant: SCLAVO SPA

Inventor： BECHERUCCI CRISTINA ,  PERRETTI MAURO ,  SILVESTRI SERGIO ,  PARENTE LUCA

IPC: A61K38/07 ,  A61K38/00 ,  A61P29/00 ,  C07K5/10 ,  A61K

Abstract: The use of natural tuftsin (I) and retro-inverted tuftsin (II) or a pharmaceutically acceptable salt of basic or acid addition thereof as anti-inflammatory agents for the treatment of illnesses of inflammatory pathogenesis is described, together with pharmaceutical compositions comprising a therapeutically effective quantity of compound (I) or (II) or of their salts of addition.

公开(公告)号：IT9019110A1

公开(公告)日：1991-07-20

申请号：IT1911090

申请日：1990-01-19

Applicant: SCLAVO SPA

Inventor： KEENAN CATHERINE ,  MUGRIDGE KENNETH ,  PARENTE LUCA ,  WALLACE JOHN

IPC: A61K38/00 ,  A61K20060101 ,  A61K31/60 ,  A61K38/20 ,  A61P1/04