公开(公告)号：IT8922251A1

公开(公告)日：1991-05-03

申请号：IT2225189

申请日：1989-11-03

Applicant: SCLAVO SPA

Inventor： PERRETTI MAURO ,  BECHERUCCI CRISTINA ,  MUGRIDGE KENNETH GORDON ,  SOLITO EGLE ,  PRESENTINI RIVO ,  PARENTE LUCA

IPC: C07C20060101 ,  A61K20060101

公开(公告)号：CA2034618A1

公开(公告)日：1992-07-22

申请号：CA2034618

申请日：1991-01-21

Applicant: SCLAVO SPA

Inventor： PERRETTI MAURO ,  BECHERUCCI CRISTINA ,  MUGRIDGE KENNETH G ,  SOLITO EGLE ,  PRESENTINI RIVO ,  PARENTE LUCA

IPC: A61K38/08 ,  A61P29/00 ,  C07K7/06

Abstract: SYNTHETIC PEPTIDE DERIVED FROM HUMAN LIPOCORTIN V AND USE THEREOF The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val- Phe-Asp-Lys-OH and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. Said peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.

公开(公告)号：IT8922251D0

公开(公告)日：1989-11-03

申请号：IT2225189

申请日：1989-11-03

Applicant: SCLAVO SPA

Inventor： PERRETTI MAURO ,  BECHERUCCI CRISTINA ,  MUGRIDGE KENNETH GORDON ,  SOLITO EGLE ,  PRESENTINI RIVO ,  PARENTE LUCA

IPC: A61K20060101 ,  C07C20060101 ,  C07C ,  A61K

Abstract: The synthetic peptide with the formula (I): H-Ser-His-Leu-Arg-Lys-Val-Phe-Asp-Lys-OH and its organic or inorganic salts physiologically acceptably are new. The synthetic peptide (I), whose amino acid sequence corresponds to that of segment 204-212 of the human lipcortin V, shows in in-vitro conditions the ability to inhibit the release of E2 prostaglandin and in live conditions has an anti-inflammatory effect. Said peptide (I) and its organic and inorganic salts are used as therapeutic reactants in treating inflammatory, dermatological and collagen infections.