公开(公告)号：MY143486A

公开(公告)日：2011-05-31

申请号：MYPI20070962

申请日：2007-06-14

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANCE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

IPC: C07C233/04

Abstract: COMPOUNDS OF FOMULA (I): MEDICAMENTS.

公开(公告)号：BR0316095A

公开(公告)日：2005-09-27

申请号：BR0316095

申请日：2003-11-04

Applicant: SERVIER LAB

Inventor： POISSONIER-DURIEUX SOPHIE ,  YOUS SAID ,  LESIEUR DANIEL ,  BENNEJEAN CAROLINE ,  DELAGRANCE PHILIPPE ,  RENARD PIERRE

IPC: A61P1/00 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P15/18 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02 ,  C07C233/18 ,  C07C233/36 ,  C07C233/60 ,  C07D207/26 ,  C07D207/27 ,  A61K31/16 ,  A61K31/40

Abstract: 1-(Amido-, ureido- or carbamoyl-alkyl)-3-(substituted methyl-phenyl)-naphthalene derivatives (I) are new. Phenyl-naphthalene derivatives of formula (I) and their enantiomers, diastereomers and acid or base addition salts are new. A = -NR2-CO-R1, -NR2-CO-NR1R'1 or -CO-NR1R'1; R1, R'1 = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-8C cycloalkyl, (3-8C) cycloalkyl-(1-6C) alkyl, aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; R2 = H or alkyl; or R1 + R2 = 3-6C linear or branched alkylene; R3 = 1-6C alkoxy; R4 = halo, OH, 1-6C alkoxy, NH2 or mono- or di-(1-6C alkyl)-amino; aryl moieties = phenyl, naphthyl or biphenylyl (all optionally substituted by 1-3 of 1-6C alkyl, 1-6C alkoxy, OH, COOH, CHO, NO2, CN, 1-6C polyhaloalkyl, alkoxycarbonyl or halo); p = 1-3; heteroaryl moieties = mono- or bicyclic aromatic group containing 1-3 of O, S and N as heteroatom(s) (optionally substituted as for aryl). Independent claims are included for: (a) the preparation of (I); and (b) new alkoxycarbonylphenyl-naphthalene derivative intermediates of formula (V) and their enantiomers, diastereomers and acid or base addition salts. R'5 = (1-6C) alkoxycarbonyl.

公开(公告)号：BR0200871A

公开(公告)日：2003-01-07

申请号：BR0200871

申请日：2002-03-19

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANCE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  A61P25/00

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.