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1.发明申请METHOD OF DETECTING AUTOANTIBODIES FROM PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS, A PEPTIDE AND AN ASSAYKIT 审中-公开从患有炎热性疾病的患者中检测自身抗体的方法，肽和测定试剂
公开(公告)号：WO03050542A2
公开(公告)日：2003-06-19
申请号：PCT/NL0200815
申请日：2002-12-11
Applicant: STICHTING TECH WETENSCHAPP , VAN VENROOIJ WALTHERUS JACOBUS , DRIJFHOUT JAN WOUTER , VAN BOEKEL MARTINUS ADRIANUS M , PRUIJN GERARDUS JOZEF MARIA
Inventor： VAN VENROOIJ WALTHERUS JACOBUS , DRIJFHOUT JAN WOUTER , VAN BOEKEL MARTINUS ADRIANUS M , PRUIJN GERARDUS JOZEF MARIA
CPC classification number: G01N33/564 , C07K7/08 , C07K7/52 , C07K7/64 , C07K14/4713 , G01N2410/00 , G01N2800/102 , Y10S435/973 , Y10S435/975 , Y10S530/806
Abstract: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glycine.
Abstract translation: 本发明涉及从患有类风湿性关节炎的患者中检测自身抗体的方法。 为此，根据本发明，使用至少两个肽单元，其中至少一个肽单元包含不衍生自（pro）填充蛋白，纤维蛋白，纤维蛋白原，波形蛋白，细胞角蛋白1和细胞角蛋白9的部分，哪个肽单元 包含基序XG和包含基序XnonG的肽单元，其中X是瓜氨酸或其类似物，而nonG是除甘氨酸以外的氨基酸。
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2.发明申请PEPTIDE DERIVED FROM AN ANTIGEN RECOGNIZED BY AUTOANTIBODIES FROM PATIENTS WITH RHEUMATOID ARTHRITIS, ANTIBODY DIRECTED AGAINST SAID PEPTIDE, A COMBINATORIAL ANTIGEN, AND A METHOD OF DETECTING AUTO-IMMUNE ANTIBODIES 审中-公开由抗自身抗体鉴定的抗生素衍生自患有炎症性角膜炎的患者的抗原，针对抗原肽的抗体，组合抗原以及检测自身免疫抗体的方法
公开(公告)号：WO9822503A3
公开(公告)日：1998-08-27
申请号：PCT/NL9700624
申请日：1997-11-14
Applicant: STICHTING SCHEIKUNDIG ONDERZOE , STICHTING TECH WETENSCHAPP , VENROOIJ WALTHERUS JACOBUS WIL , SCHELLEKENS GERARDUS ANTONIUS , RAATS JOZEF MARIA HENDRIK , HOET RENE MICHAEL ANTONIUS
Inventor： VAN VENROOIJ WALTHERUS JACOBUS , SCHELLEKENS GERARDUS ANTONIUS , RAATS JOZEF MARIA HENDRIK , HOET RENE MICHAEL ANTONIUS
IPC: C07K7/08 , C07K14/47 , C07K16/18 , C12P21/08 , G01N33/564
CPC classification number: G01N33/6893 , C07K14/47 , C07K14/4713 , C07K16/18 , G01N33/564 , G01N2333/46 , G01N2800/10 , G01N2800/102 , G01N2800/24
Abstract: The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.
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公开(公告)号：DK0941244T3
公开(公告)日：2007-04-30
申请号：DK97912577
申请日：1997-11-14
Applicant: STICHTING TECH WETENSCHAPP
Inventor： VAN VENROOIJ WALTHERUS JACOBUS , SCHELLEKENS GERARDUS ANTONIUS , HOET RENE MICHAEL ANTONIUS , RAATS JOZEF MARIA HENDRIK
Abstract: The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.
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公开(公告)号：CA2489167A1
公开(公告)日：2003-06-19
申请号：CA2489167
申请日：2002-12-11
Applicant: STICHTING TECH WETENSCHAPP
Inventor： PRUIJN GERARDUS JOZEF MARIA , VAN VENROOIJ WALTHERUS JACOBUS , VAN BOEKEL MARTINUS ADRIANUS M , DRIJFHOUT JAN WOUTER
Abstract: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention , at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glyci ne.
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公开(公告)号：AT329267T
公开(公告)日：2006-06-15
申请号：AT02786237
申请日：2002-12-11
Applicant: STICHTING TECH WETENSCHAPP
Inventor： VAN VENROOIJ WALTHERUS JACOBUS , DRIJFHOUT JAN WOUTER , VAN BOEKEL MARTINUS ADRIANUS M , PRUIJN GERARDUS JOZEF MARIA
Abstract: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glycine.
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Patent Agency Ranking
公开(公告)号：ES2266603T3
公开(公告)日：2007-03-01
申请号：ES02786237
申请日：2002-12-11
Applicant: STICHTING TECH WETENSCHAPP
Inventor： VAN VENROOIJ WALTHERUS JACOBUS , DRIJFHOUT JAN WOUTER , VAN BOEKEL MARTINUS ADRIANUS M , PRUIJN GERARDUS JOZEF MARIA
Abstract: Una unidad peptídica que comprende una secuencia seleccionada del grupo que consiste en péptido 0002-27 HQKRGCitGWSRAA, péptido 0002-29 HQRRVCitGWSRAA, péptido 0002-31 HQRRTCitGGSRAA, péptido 0002-32 HQRKWCitGASRAA, péptido 0002- 36 HQFRFCitGCitSRAA, péptido 0002-37 HQKWRCitGRSCitAA y péptido 0002-63 HQFRFCitGWSRAA.
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公开(公告)号：AT352560T
公开(公告)日：2007-02-15
申请号：AT97912577
申请日：1997-11-14
Applicant: STICHTING TECH WETENSCHAPP
Inventor： VAN VENROOIJ WALTHERUS JACOBUS , SCHELLEKENS GERARDUS ANTONIUS , RAATS JOZEF MARIA HENDRIK , HOET RENE MICHAEL ANTONIUS
Abstract: The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.
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公开(公告)号：SI1456662T1
公开(公告)日：2006-12-31
申请号：SI200230389
申请日：2002-12-11
Applicant: STICHTING TECH WETENSCHAPP
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公开(公告)号：ES2281095T3
公开(公告)日：2007-09-16
申请号：ES97912577
申请日：1997-11-14
Applicant: STICHTING TECH WETENSCHAPP
Inventor： VAN VENROOIJ WALTHERUS JACOBUS , SCHELLEKENS GERARDUS ANTONIUS , RAATS JOZEF MARIA HENDRIK , HOET RENE MICHAEL ANTONIUS
Abstract: LA PRESENTE INVENCION SE REFIERE A UN PEPTIDO DERIVADO DE UN ANTIGENO RECONOCIDO POR AUTOANTICUERPOS; DICHO PEPTIDO REACCIONA CON ANTICUERPOS AUTOINMUNES QUE PROCEDEN DE UN PACIENTE QUE PADECE DE POLIARTRITIS REUMATOIDE. EL PEPTIDO DE ESTA INVENCION TIENE UN RESTO ARGININO MODIFICADO. ESTA INVENCION SE REFIERE TAMBIEN A UNOS ANTICUERPOS DIRIGIDOS CONTRA ESTE PEPTIDO, ASI COMO A UN PROCEDIMIENTO DE DETECCION DE ANTICUERPOS AUTOINMUNES.
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公开(公告)号：DK1456662T3
公开(公告)日：2006-09-18
申请号：DK02786237
申请日：2002-12-11
Applicant: STICHTING TECH WETENSCHAPP
Inventor： VAN VENROOIJ WALTHERUS JACOBUS , DRIJFHOUT JAN WOUTER , VAN BOEKEL MARTINUS ADRIANUS M , PRUIJN GERARDUS JOZEF MARIA
Abstract: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glycine.
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