公开(公告)号：WO1996011878A1

公开(公告)日：1996-04-25

申请号：PCT/US1995013278

申请日：1995-10-18

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SYMYX TECHNOLOGIES

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SYMYX TECHNOLOGIES ,  SCHULTZ, Peter, G. ,  XIANG, Xiaodong ,  GOLDWASSER, Isy

IPC: C01G51/04

CPC classification number: C04B35/16 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00432 ,  B01J2219/00436 ,  B01J2219/00441 ,  B01J2219/00443 ,  B01J2219/00475 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00646 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00752 ,  B01J2219/00754 ,  B82Y25/00 ,  B82Y30/00 ,  C01G51/006 ,  C01G51/68 ,  C01P2002/34 ,  C01P2002/52 ,  C01P2002/72 ,  C01P2006/40 ,  C01P2006/42 ,  C04B35/01 ,  C04B35/4508 ,  C04B35/4521 ,  C04B35/4525 ,  C04B35/62218 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3262 ,  C04B2235/327 ,  C04B2235/3275 ,  C04B2235/3284 ,  C04B2235/3286 ,  C04B2235/3296 ,  C04B2235/3298 ,  C04B2235/3418 ,  C04B2235/3463 ,  C04B2235/656 ,  C04B2235/761 ,  C04B2235/762 ,  C04B2235/768 ,  C04B2235/96 ,  C23C14/042 ,  C23C14/087 ,  C23C16/042 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  C40B80/00 ,  G01R33/16 ,  H01F1/401 ,  H01F1/407 ,  H01F10/007 ,  H01F10/1933 ,  H01F41/18 ,  H01F41/34 ,  H01L43/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  Y10T428/2462 ,  Y10T428/31 ,  Y10T428/31645 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T436/25 ,  Y10T436/2525 ,  Y10T436/255 ,  Y10T436/25875

Abstract: Giant magnetoresistive cobalt oxide compounds are produced by combinatorial synthesis. Combinatorial synthesis is done by using a substrate having an array of diverse materials thereon prepared by delivering components to predefined regions on a substrate and simultaneously reacting the components to form at least two materials. Other materials that can be prepared using these methods are covalent network solids, ionic solids and molecular solids. Examples are inorganic, organometallic, intermetallic, ceramic organic polymeric and composite materials. Once prepared, these materials can be screened for useful properties such as magnetoresistance. Thus, the present invention provides for the parallel synthesis and analysis of novel material having useful properties.

Abstract translation: 巨磁阻氧化钴化合物是通过组合合成制得的。 通过使用其上具有不同材料阵列的衬底，通过将组分递送到衬底上的预定区域并同时使组分反应以形成至少两种材料来进行组合合成。 可以使用这些方法制备的其他材料是共价网络固体，离子固体和分子固体。 实例是无机，有机金属，金属间化合物，陶瓷有机聚合物和复合材料。 一旦制备好，这些材料可以被筛选出有用的特性，例如磁阻。 因此，本发明提供了具有有用特性的新型材料的并行合成和分析。

公开(公告)号：WO1998014641A1

公开(公告)日：1998-04-09

申请号：PCT/US1997017682

申请日：1997-09-30

Applicant: SYMYX TECHNOLOGIES

Inventor： SYMYX TECHNOLOGIES ,  McFARLAND, Eric ,  DANIELSON, Earl ,  DEVENNEY, Martin ,  WARREN, Christopher, J.

IPC: C25D05/02

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00371 ,  B01J2219/00436 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00686 ,  B01J2219/00702 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00752 ,  B01J2219/00754 ,  B01J2219/00756 ,  B01L3/0241 ,  B01L3/5085 ,  C25D5/02 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  H01F1/404 ,  H01F41/34

Abstract: Methods and apparatus are provided for the preparation of a substrate having an array of diverse materials, the materials being deposited at spatially addressable, predefined regions. In particular, potential masking systems are provided which generate spatially and temporally varying electric, magnetic and chemical potentials across a substrate. These varying potentials are used to deposit components of source materials onto a substrate in a combinatorial fashion, thus creating arrays of materials that differ slightly in chemical composition, concentration, stoichiometry, and/or thickness. The diverse materials may be organized in discrete arrays, or they may vary continuously over the surface of the substrate. The shape of the potential allows the determination of the composition of the resulting materials at all locations on the substrate.

Abstract translation: 提供了用于制备具有不同材料阵列的基材的方法和装置，该材料沉积在空间可寻址的预定区域。 特别地，提供了潜在的掩蔽系统，其在衬底上产生空间和时间上变化的电，磁和化学势。 这些变化的电位用于以组合的方式将源材料的成分沉积到衬底上，从而产生化学组成，浓度，化学计量和/或厚度略有不同的材料阵列。 不同的材料可以以离散阵列组织，或者它们可以在衬底的表面上连续变化。 电位的形状允许确定所得材料在基底上所有位置的组成。

公开(公告)号：WO1998003521A1

公开(公告)日：1998-01-29

申请号：PCT/US1997013312

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES ,  WEINBERG, W., Henry ,  McFARLAND, Eric ,  GOLDWASSER, Isy ,  BOUSSIE, Thomas ,  TURNER, Howard ,  VAN BEEK, Johannes, A., M. ,  MURPHY, Vince ,  POWERS, Timothy

Inventor： SYMYX TECHNOLOGIES

IPC: C07F19/00

CPC classification number: G01N29/0681 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C40B40/18 ,  C40B60/14 ,  G01N29/2418 ,  G01N29/348 ,  G01N2291/106 ,  C08F4/7006 ,  C08F4/7081

Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

Abstract translation: 本发明尤其涉及有机金属化合物和催化剂（例如均相催化剂）的合成，筛选和表征的方法。 本发明的方法提供了负载和未负载的有机金属化合物和催化剂（例如均相催化剂）的文库的组合合成，筛选和表征。 本发明的方法可用于大量有机金属化合物的制备和筛选，所述有机金属化合物不仅可用作催化剂（例如均相催化剂），而且可用作添加剂和治疗剂。

公开(公告)号：WO1998015805A1

公开(公告)日：1998-04-16

申请号：PCT/US1997018521

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES

Inventor： SYMYX TECHNOLOGIES ,  McFARLAND, Eric, W. ,  DANIELSON, Earl ,  ARCHIBALD, William

IPC: G01J04/00

CPC classification number: G01N29/2425 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B20/08 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/12 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N9/002 ,  G01N11/16 ,  G01N21/211 ,  G01N21/253 ,  G01N21/6402 ,  G01N21/6452 ,  G01N21/66 ,  G01N25/4813 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N31/10 ,  G01N2009/006 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/106 ,  H01J49/0409 ,  H01J49/0468

Abstract: Methods and apparatus for screening diverse arrays of materials (1205) are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials (1205) in order to discover and/or optimize new materials with specific desired properties are provided. The substrate (403) can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems (1200, 1300, 1400) and methods are provided for screening a library of magnetic materials (1205) for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials (1205) for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems (1200, 1300, 1400) are also provided as well as their application to screening libraries of different materials (1205).

Abstract translation: 提供了用于筛选各种材料阵列的方法和装置（1205）。 特别地，提供了用于快速表征材料阵列中的化合物（1205）以便发现和/或优化具有特定期望性质的新材料的技术。 对于具有有用特性的材料，可以对基底（403）进行筛选，和/或可以对所得到的材料进行排序或以其他方式比较相对于有用特性或其它特征的相对性能。 特别地，提供了系统（1200,1300,1400）和方法，用于通过对其各自的光克尔旋转进行成像来筛选磁性材料库（1205）以获得其体磁化强度，饱和磁化强度和矫顽力，筛选介电材料库（ 1205），通过对其各自的电光旋转进行成像，并通过在各种激发条件下成像其各自的发光特性来筛选发光材料的文库来实现它们的介电系数。 还提供光学或可见发光系统（1200,1300,1400）以及它们用于筛选不同材料的文库（1205）。

公开(公告)号：WO1998015501A2

公开(公告)日：1998-04-16

申请号：PCT/US1997018192

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES

Inventor： SYMYX TECHNOLOGIES ,  MCFARLAND, Eric ,  MATSIEV, Leonid

IPC: C01G00/00

CPC classification number: G01N29/2425 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B20/08 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/12 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N9/002 ,  G01N11/16 ,  G01N21/211 ,  G01N21/253 ,  G01N21/6402 ,  G01N21/6452 ,  G01N21/66 ,  G01N25/4813 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N31/10 ,  G01N2009/006 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/106 ,  H01J49/0409 ,  H01J49/0468

Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In one aspect, systems and methods are provided for imaging a library of materials using ultrasonic imaging techniques. The system includes one or more devices for exciting an element of the library such that acoustic waves are propagated through, and from, the element. The acoustic waves propagated from the element are detected and processed to yield a visual image of the library element. The acoustic wave data can also be processed to obtain information about the elastic properties of the library element. In another aspect, systems and methods are provided for generating acoustic waves in a tank filled with a coupling liquid. The library of materials is then placed in the tank and the surface of the coupling liquid is scanned with a laser beam. The structure of the liquid surface disturbed by the acoustic wave is recorded, the recorded disturbance being representative of the physical structure of the library. In another aspect of the invention, a mechanical resonator is used to evaluate various properties (e.g., molecular weight, viscosity, specific weight, elasticity, dielectric constant, conductivity, etc.) of the individual liquid elements of a library of materials. The resonator is designed to ineffectively excite acoustic waves. The frequency response of the resonator is measured for the liquid element under test, preferably as a function of time. By calibrating the resonator to a set of standard liquids with known properties, the properties of the unknown liquid can be determined. An array of library elements can be characterized by a single scanning transducer or by using an array of transducers corresponding to the array of library elements. Alternatively, multiple resonators of differing design may be used to evaluate each element of a library of elements, thus providing improved dynamic range and sensitivity.

Abstract translation: 提供了筛选各种材料阵列的方法和装置。 在一个方面，提供了使用超声成像技术对材料库进行成像的系统和方法。 该系统包括用于激发库的元件的一个或多个装置，使得声波通过元件传播并从元件传播。 从元件传播的声波被检测和处理以产生库元件的视觉图像。 还可以处理声波数据以获得关于库元件的弹性特性的信息。 在另一方面，提供了用于在填充有耦合液体的罐中产生声波的系统和方法。 然后将材料库放置在罐中，并用激光束扫描耦合液体的表面。 记录由声波扰动的液面的结构，记录的干扰代表图书馆的物理结构。 在本发明的另一方面，使用机械谐振器来评估材料库的各个液体元件的各种性质（例如，分子量，粘度，比重，弹性，介电常数，电导率等）。 谐振器被设计为无效地激发声波。 测量谐振器的频率响应，优选作为时间的函数。 通过将谐振器校准为具有已知性质的一组标准液体，可以确定未知液体的性质。 可以通过单个扫描换能器或通过使用对应于库元件阵列的换能器阵列来表征库元件的阵列。 或者，可以使用不同设计的多个谐振器来评估元件库的每个元件，从而提供改善的动态范围和灵敏度。

公开(公告)号：WO1998015969A3

公开(公告)日：1998-04-16

申请号：PCT/US1997018147

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES

Inventor： SYMYX TECHNOLOGIES ,  WEINBERG, W., Henry ,  MCFARLAND, Eric, W. ,  CONG, Peijun ,  GUAN, Shenheng

IPC: H01J49/00

Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques are provided for rapidly characterizing compounds in combinatorial arrays of materials for discovering and/or optimizing new materials with specific desired properties. According to one aspect, a scanning mass spectrometer is used which includes an ionization chamber and a collector that outputs an electrical signal responsive to the quantity of gas ions contacting the collector surface. A conduit system selectively withdraws samples from the array of materials, passing the samples into the ionization chamber. In a specific embodiment, reactants are passed through the conduit system to the selected regions of interest on the substrate. Means are provided to selectively heat regions on the substrate.

公开(公告)号：WO1998015813A1

公开(公告)日：1998-04-16

申请号：PCT/US1997018177

申请日：1997-10-07

Applicant: SYMYX TECHNOLOGIES

Inventor： SYMYX TECHNOLOGIES ,  McFARLAND, Eric, W. ,  ARCHIBALD, William

IPC: G01N21/35

CPC classification number: G01N29/2425 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B20/08 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/12 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N9/002 ,  G01N11/16 ,  G01N21/211 ,  G01N21/253 ,  G01N21/6402 ,  G01N21/6452 ,  G01N21/66 ,  G01N25/4813 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N31/10 ,  G01N2009/006 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/106 ,  H01J49/0409 ,  H01J49/0468

Abstract: Methods and apparatus for screening diverse arrays of materials using infrared imaging techniques are provided. Typically, each of the individual materials on the array will be screened or interrogated for the same material characteristic. Once screened, the individual materials may be ranked or otherwise compared relative to each other with respect to the material characteristic under investigation. According to one aspect, infrared imaging techniques are used to identify the active sites within an array of compounds by monitoring the temperature change resulting from a reaction. This same technique can also be used to quantify the stability of each new material within an array of compounds. According to another aspect, identification and characterization of condensed phase products is achieved, wherein library elements are activated by a heat source serially, or in parallel. According to another aspect, a Fourier transform infrared spectrometer is used to rapidly characterize a large number of chemical reactions contained within a combinatorial library.

Abstract translation: 提供了使用红外成像技术筛选各种材料阵列的方法和装置。 通常，对于相同的材料特性，阵列上的每个单独的材料将被筛选或询问。 一旦筛选，单个材料可以相对于被调查的材料特性相对于彼此进行排序或以其他方式比较。 根据一个方面，红外成像技术用于通过监测由反应产生的温度变化来鉴定化合物阵列内的活性位点。 也可以使用相同的技术来量化化合物阵列内的每种新材料的稳定性。 根据另一方面，实现冷凝相产物的鉴定和表征，其中文库元素被串联或并联的热源活化。 根据另一方面，使用傅里叶变换红外光谱仪来快速表征包含在组合文库中的大量化学反应。