公开(公告)号：WO1998014641A1

公开(公告)日：1998-04-09

申请号：PCT/US1997017682

申请日：1997-09-30

Applicant: SYMYX TECHNOLOGIES

Inventor： SYMYX TECHNOLOGIES ,  McFARLAND, Eric ,  DANIELSON, Earl ,  DEVENNEY, Martin ,  WARREN, Christopher, J.

IPC: C25D05/02

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00371 ,  B01J2219/00436 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00686 ,  B01J2219/00702 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00752 ,  B01J2219/00754 ,  B01J2219/00756 ,  B01L3/0241 ,  B01L3/5085 ,  C25D5/02 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  H01F1/404 ,  H01F41/34

Abstract: Methods and apparatus are provided for the preparation of a substrate having an array of diverse materials, the materials being deposited at spatially addressable, predefined regions. In particular, potential masking systems are provided which generate spatially and temporally varying electric, magnetic and chemical potentials across a substrate. These varying potentials are used to deposit components of source materials onto a substrate in a combinatorial fashion, thus creating arrays of materials that differ slightly in chemical composition, concentration, stoichiometry, and/or thickness. The diverse materials may be organized in discrete arrays, or they may vary continuously over the surface of the substrate. The shape of the potential allows the determination of the composition of the resulting materials at all locations on the substrate.

Abstract translation: 提供了用于制备具有不同材料阵列的基材的方法和装置，该材料沉积在空间可寻址的预定区域。 特别地，提供了潜在的掩蔽系统，其在衬底上产生空间和时间上变化的电，磁和化学势。 这些变化的电位用于以组合的方式将源材料的成分沉积到衬底上，从而产生化学组成，浓度，化学计量和/或厚度略有不同的材料阵列。 不同的材料可以以离散阵列组织，或者它们可以在衬底的表面上连续变化。 电位的形状允许确定所得材料在基底上所有位置的组成。

公开(公告)号：WO2003014732A1

公开(公告)日：2003-02-20

申请号：PCT/US2002/016962

申请日：2002-05-24

Applicant: SYMYX TECHNOLOGIES, INC. ,  CARLSON, Eric, D. ,  CONG, Peijun ,  CHANDLER, William, H., Jr. ,  CHAU, Henry, K. ,  DANIELSON, Earl ,  DESROSIERS, Peter, J. ,  DOOLAN, Robert, D. ,  WU, Luping

Inventor： CARLSON, Eric, D. ,  CONG, Peijun ,  CHANDLER, William, H., Jr. ,  CHAU, Henry, K. ,  DANIELSON, Earl ,  DESROSIERS, Peter, J. ,  DOOLAN, Robert, D. ,  WU, Luping

IPC: G01N33/48

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymporphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system.

Abstract translation: 本发明提供了用于进行候选药物的盐和多形态的高通量制备和筛选的方法，装置和系统。 本发明旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定基本上发现可以从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。

公开(公告)号：WO1998015805A1

公开(公告)日：1998-04-16

申请号：PCT/US1997018521

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES

Inventor： SYMYX TECHNOLOGIES ,  McFARLAND, Eric, W. ,  DANIELSON, Earl ,  ARCHIBALD, William

IPC: G01J04/00

CPC classification number: G01N29/2425 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B20/08 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/12 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N9/002 ,  G01N11/16 ,  G01N21/211 ,  G01N21/253 ,  G01N21/6402 ,  G01N21/6452 ,  G01N21/66 ,  G01N25/4813 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N31/10 ,  G01N2009/006 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/106 ,  H01J49/0409 ,  H01J49/0468

Abstract: Methods and apparatus for screening diverse arrays of materials (1205) are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials (1205) in order to discover and/or optimize new materials with specific desired properties are provided. The substrate (403) can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems (1200, 1300, 1400) and methods are provided for screening a library of magnetic materials (1205) for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials (1205) for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions. Optical or visible luminescence systems (1200, 1300, 1400) are also provided as well as their application to screening libraries of different materials (1205).

Abstract translation: 提供了用于筛选各种材料阵列的方法和装置（1205）。 特别地，提供了用于快速表征材料阵列中的化合物（1205）以便发现和/或优化具有特定期望性质的新材料的技术。 对于具有有用特性的材料，可以对基底（403）进行筛选，和/或可以对所得到的材料进行排序或以其他方式比较相对于有用特性或其它特征的相对性能。 特别地，提供了系统（1200,1300,1400）和方法，用于通过对其各自的光克尔旋转进行成像来筛选磁性材料库（1205）以获得其体磁化强度，饱和磁化强度和矫顽力，筛选介电材料库（ 1205），通过对其各自的电光旋转进行成像，并通过在各种激发条件下成像其各自的发光特性来筛选发光材料的文库来实现它们的介电系数。 还提供光学或可见发光系统（1200,1300,1400）以及它们用于筛选不同材料的文库（1205）。

公开(公告)号：EP1425577A1

公开(公告)日：2004-06-09

申请号：EP02731970.6

申请日：2002-05-24

Applicant: SYMYX TECHNOLOGIES

Inventor： CARLSON, Eric, D. ,  CONG, Peijun ,  CHANDLER, William, H., Jr. ,  CHAU, Henry, K. ,  DANIELSON, Earl ,  DESROSIERS, Peter, J. ,  DOOLAN, Robert, D. ,  WU, Luping

IPC: G01N33/48

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymporphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system.

公开(公告)号：EP1328959A1

公开(公告)日：2003-07-23

申请号：EP01959261.7

申请日：2001-07-27

Applicant: Osram Opto Semiconductors GmbH & Co. OHG ,  Symyx Technologies, Inc.

Inventor： DANIELSON, Earl ,  ELLENS, Andries ,  JERMANN, Frank ,  ROSSNER, Wolfgang ,  DEVENNEY, Martin ,  GIAQUINTA, Daniel ,  KOBUSCH, Manfred

IPC: H01J33/00 ,  H01J1/62

CPC classification number: H01L33/502 ,  C09K11/773 ,  C09K11/7731 ,  C09K11/7774 ,  C09K11/7786 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/73265 ,  Y02B20/181 ,  H01L2924/00014

Abstract: A device for the generation of specific colored light including white light by luminescent down conversion and additive color mixing based on a light-emitting diode 'LED'(1) comprising a semiconductor light-emitting layer emitting near UV light about 370-420 nm or blue light about 420-480 nm and phosphors (6) which absorb completely or partly the light emitted by the light-emitting component and emit light of wavelengths longer than that of the absorbed primary light, wherein the light emitting layer of the light emitting component is preferably a Ga(In)N-based semiconductor; and at least one of the phosphors (6) contains a metal sulfide fluorescent material activated with europium containing at least one element selected from the group consisting of Ba, Sr, Ca, Mg and Zn; and/or at least another phosphor (6) which contains a complex thiometalate fluorescent material activated with either europium, cerium or both europium and cerium containing at least one element selected from the group consisting of Ba, Sr, Ca, Mg and Zn; and at least one element selected from the group consisting of Al, Ga, In, Y, La and Gd.