公开(公告)号：AU7333101A

公开(公告)日：2002-01-21

申请号：AU7333101

申请日：2001-07-09

Applicant: SYMYX TECHNOLOGIES INC

Inventor： LUGMAIR CLAUS ,  HAGEMEYER ALFRED ,  ERDEN LYNN VAN ,  VOLPE ANTHONY F JR ,  LOWE DAVID M ,  LIU YUMIN

IPC: B01J19/00 ,  B01J37/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10

Abstract: Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.

公开(公告)号：AU7331701A

公开(公告)日：2002-01-21

申请号：AU7331701

申请日：2001-07-09

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HAGEMEYER ALFRED ,  VOLPE ANTHONY F JR ,  LEFORT LAURENT ,  LUGMAIR CLAUS ,  LOWE DAVID M ,  LIU YUMIN ,  BERGH H SAM ,  GUAN SHENHENG ,  PINKAS DANIEL M ,  ENGSTROM JAMES R ,  SELF KYLE W

IPC: B01J19/00 ,  B01J37/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10

Abstract: Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.

公开(公告)号：AU5014900A

公开(公告)日：2000-12-05

申请号：AU5014900

申请日：2000-05-15

Applicant: SYMYX TECHNOLOGIES INC ,  BAYER AG

Inventor： POOJARY DAMODARA ,  BORADE RAMESH ,  HAGEMEYER ALFRED ,  DUBE CHRISTOPHER E ,  ZHOU ZIAO PING ,  NOTHELS ULRICH ,  ARMBRUST RALPH ,  RASP CHRISTIAN ,  LOWE DAVID M

IPC: C07C209/02 ,  C07C211/46

公开(公告)号：WO0069804A9

公开(公告)日：2001-03-29

申请号：PCT/US0013266

申请日：2000-05-15

Applicant: SYMYX TECHNOLOGIES INC ,  BAYER AG ,  POOJARY DAMODARA ,  BORADE RAMESH ,  HAGEMEYER ALFRED ,  DUBE CHRISTOPHER E ,  ZHOU ZIAO PING ,  NOTHELS ULRICH ,  ARMBRUST RALPH ,  RASP CHRISTIAN ,  LOWE DAVID M

Inventor： POOJARY DAMODARA ,  BORADE RAMESH ,  HAGEMEYER ALFRED ,  DUBE CHRISTOPHER E ,  ZHOU ZIAO PING ,  NOTHELS ULRICH ,  ARMBRUST RALPH ,  RASP CHRISTIAN ,  LOWE DAVID M

IPC: C07C209/02 ,  C07C211/46

CPC classification number: C07C209/02 ,  Y02P20/582 ,  C07C211/46

Abstract: Noble metal/reducible metal oxide catalysts effective for the direct amination of aromatic hydrocarbons and heterocyclic analogs thereof are disclosed. In one embodiment, the cataloxidant comprises a noble metal selected from Pd, Rh, Ir and/or Ru and a reducible metal oxide. In another embodiment, the cataloxidant comprises a noble metal and a reducible oxide of a metal selected from Ni, Mn, V, Ce, Tb, Pr, Te, Re, Co, Fe, Cu and/or Bi. A preferred catloxidant comprises one or more noble metals selected from Pd, Rh, Ir and/or Ru, in combination with nickel oxide and/or manganese oxide. In preferred applications, benzene can be aminated in the presence of the cataloxidants to form aniline. A benzene conversion of at least 5 % is achieved, with more than 90 % selectivity for aniline. Significantly, the cataloxidant can be regenerated without a substantial loss of performance.

Abstract translation: 公开了对芳烃和其杂环类似物的直接胺化有效的贵金属/可还原金属氧化物催化剂。 在一个实施方案中，所述催化剂包含选自Pd，Rh，Ir和/或Ru的贵金属和可还原的金属氧化物。 在另一个实施方案中，所述催化剂包含贵金属和选自Ni，Mn，V，Ce，Tb，Pr，Te，Re，Co，Fe，Cu和/或Bi的金属的还原氧化物。 优选的螯合剂包含与氧化镍和/或氧化锰组合的一种或多种选自Pd，Rh，Ir和/或Ru的贵金属。 在优选的应用中，苯可以在催化剂存在下胺化形成苯胺。 达到至少5％的苯转化率，对苯胺具有超过90％的选择性。 值得注意的是，可以再生催化剂，而没有显着的性能损失。

公开(公告)号：WO0204112A3

公开(公告)日：2002-05-16

申请号：PCT/US0121718

申请日：2001-07-09

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HAGEMEYER ALFRED ,  VOLPE ANTHONY F JR ,  LEFORT LAURENT ,  LUGMAIR CLAUS ,  LOWE DAVID M ,  LIU YUMIN ,  BERGH H SAM ,  GUAN SHENHENG ,  PINKAS DANIEL M ,  ENGSTROM JAMES R ,  SELF KYLE W

IPC: B01J19/00 ,  B01J37/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10

CPC classification number: B07B1/00 ,  B01J19/0046 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/009 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/007 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00756 ,  B01L3/5025 ,  B22F2998/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  B22F9/04

Abstract: Protocols for designing and implementing sets of simultaneous experiments, in a parallel, multi-variable process optimization reactor, are disclosed. The multi-variable process optimization reactor is preferably a parallel flow reactor having the operational capability to simultaneously vary reaction conditions between reaction vessels - either modularly or independently. The simultaneously varied reaction conditions preferably include at least two of the following, in various combinations and permutations: space velocity, contact time, temperature, pressure and feed composition. Compositional variations in the catalysts residing in each of the reaction vessels can also be investigated in the set of simultaneous experiments implemented in the parallel reactor. Sufficient data is obtained from a single set of simultaneous experiments to generate a master curve.

公开(公告)号：WO0204121A3

公开(公告)日：2003-01-03

申请号：PCT/US0121771

申请日：2001-07-09

Applicant: SYMYX TECHNOLOGIES INC

Inventor： LUGMAIR CLAUS ,  HAGEMEYER ALFRED ,  VANERDEN LYNN ,  VOLPE ANTHONY F JR ,  LOWE DAVID M ,  LIU YUMIN

IPC: B01J19/00 ,  B01J37/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10

CPC classification number: B07B1/00 ,  B01J19/0046 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/009 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/007 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00756 ,  B01L3/5025 ,  B22F2998/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  B22F9/04

Abstract: Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.

Abstract translation: 公开了用于组合（即，高通量）材料研究的方法和装置，例如催化研究，其涉及用于同时进行诸如研磨，混合，压制，压碎，筛分和/或分级的机械处理的并行装置。 。 所述方法和装置可用于机械处理催化材料和其它固体材料，包括但不限于电子材料如磷光体，着色剂如颜料，以及药物如结晶药物或药物候选物。 同时协议和并行设备在制备材料阵列（例如催化材料）方面提供总体通量的显着改进。

公开(公告)号：WO0204112A9

公开(公告)日：2002-10-10

申请号：PCT/US0121718

申请日：2001-07-09

Applicant: SYMYX TECHNOLOGIES INC

Inventor： HAGEMEYER ALFRED ,  VOLPE ANTHONY F JR ,  LEFORT LAURENT ,  LUGMAIR CLAUS ,  LOWE DAVID M ,  LIU YUMIN ,  BERGH H SAM ,  GUAN SHENHENG ,  PINKAS DANIEL M ,  ENGSTROM JAMES R ,  SELF KYLE W

IPC: B01J19/00 ,  B01J37/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10

CPC classification number: B07B1/00 ,  B01J19/0046 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/009 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/007 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00756 ,  B01L3/5025 ,  B22F2998/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  B22F9/04

Abstract: Protocols for designing and implementing sets of simultaneous experiments, in a parallel, multi-variable process optimization reactor, are disclosed. The multi-variable process optimization reactor is preferably a parallel flow reactor having the operational capability to simultaneously vary reaction conditions between reaction vessels - either modularly or independently. The simultaneously varied reaction conditions preferably include at least two of the following, in various combinations and permutations: space velocity, contact time, temperature, pressure and feed composition. Compositional variations in the catalysts residing in each of the reaction vessels can also be investigated in the set of simultaneous experiments implemented in the parallel reactor. Sufficient data is obtained from a single set of simultaneous experiments to generate a master curve.

Abstract translation: 公开了在并行，多变量过程优化反应器中设计和实施多组同时进行的实验的协议。 多变量过程优化反应器优选是具有操作能力的并流反应器，以便同时改变反应容器之间的反应条件 - 模块化或独立。 同时改变的反应条件优选包括以下各项中的至少两种，以各种组合和置换：空间速度，接触时间，温度，压力和进料组成。 驻留在每个反应容器中的催化剂的组成变化也可以在平行反应器中实施的一组同时实验中进行研究。 从一组同时进行的实验中获得足够的数据以生成主曲线。