公开(公告)号：DK182189A

公开(公告)日：1989-10-16

申请号：DK182189

申请日：1989-04-14

Applicant: TORAY INDUSTRIES

Inventor： OHNO MASAJI ,  MUTOH MASATO ,  HATA GO ,  MATSUNAGA KEIICHI ,  HANADA SATOSHI

IPC: C07F15/00 ,  C07C87/14 ,  C07D309/32 ,  C07D309/36

公开(公告)号：DK182189D0

公开(公告)日：1989-04-14

申请号：DK182189

申请日：1989-04-14

Applicant: TORAY INDUSTRIES

Inventor： OHNO MASAJI ,  MUTOH MASATO ,  HATA GO ,  MATSUNAGA KEIICHI ,  HANADA SATOSHI

IPC: C07F15/00 ,  C07C87/14 ,  C07D309/32 ,  C07D309/36

公开(公告)号：DK538187A

公开(公告)日：1988-04-16

申请号：DK538187

申请日：1987-10-14

Applicant: TORAY INDUSTRIES

Inventor： OHNO MASAJI ,  MUTOH MASATO ,  KONDO HISAO ,  MATSUNAGA KEIICHI

IPC: C07F15/00

Abstract: A platinum complex represented by the formula: wherein R is a (C1 - 18) alkyl group, a (C1 - 18)-alkenyl group or a group @@ -X @@R in which X is -CH=CH- or a (C1 - 5) alkylene group, and R is a phenyl group, a hydroxyphenyl group, a (C7 - 12) alkoxyphenyl group, a halogenophenyl group, a nitrophenyl group, or (C8 - 13) alkoxycarbonylphenyl group, a cyclohexyl group having a (C1 - 5) alkyl substituent, R is a (C1 - 18) alkyl group, R is a hydrogen atom, or R and R are linked together to form a (C2 - 7) alkylene group; R is OH or NO3; the dotted line indicates that the bond may be either a single bond or a double bond; the chain line indicates a conjugated system; n is a number of from 1 to 2, and the 1,2-diaminocyclohexane moiety has a cis- trans- l - or trans-d-configuration. This platinum complex is useful in the treatment of tumors.

公开(公告)号：JPH0311090A

公开(公告)日：1991-01-18

申请号：JP14386689

申请日：1989-06-06

Applicant: TORAY INDUSTRIES

Inventor： MATSUNAGA KEIICHI ,  IMAMURA SHINZO ,  MUTOU MASATO ,  OKAMOTO YUTAKA

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C49/733 ,  C07C211/65 ,  C07F15/00

Abstract: NEW MATERIAL:2-Acetylindane-1,3-dionyl-monohydroxo(trans-l- diaminocyclohexane)platinum of formula I. USE:A remedy for malignant tumor. PREPARATION:The objective compound can be produced by reacting dinitrato(1,2-diaminocyclohexano)platinum(II) or sulfato(1,2-diaminocyclohexane)platinum(II) of formula II [R is (NO3)2 or SO4] with 2-acetylindane-1,3-dione of formula III in the presence of an alkali metal or alkaline-earth metal hydroxide (preferably sodium hydroxide, potassium hydroxide or barium hydroxide) or reacting dihydroxo(1,2-diaminocyclohexane)platinum(II) of formula IV with the compound of formula III.

公开(公告)号：JPH0242094A

公开(公告)日：1990-02-13

申请号：JP19402088

申请日：1988-08-02

Applicant: TORAY INDUSTRIES

Inventor： HASEGAWA SAKIE ,  MATSUNAGA KEIICHI ,  MUTOU MASATO ,  SAWAHATA TADASHI

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07C211/65 ,  C07F15/00

Abstract: NEW MATERIAL:Compounds of formula I (R is 1-17C alkyl). EXAMPLE:2-Acetylcyclopentane-1,3-diode-hydroxo(trans-l-1,2-diaminocycl ohexane) platinum(II)1hydrate. USE:A remedy for malignant tumor. PREPARATION:Dinitrato(1,2-diaminocyclohexane)platinum(II) or sulfato(1,2- diaminocyclohexane)platinum(II) represented by formula II [R1 is (ONO2)2 or OSO3] is reacted with a compound (e.g., 2-acetylcyclopentane-1,3-dione) expressed by formula III in the presence of an alkali hydroxide.

公开(公告)号：JPH01143883A

公开(公告)日：1989-06-06

申请号：JP30519387

申请日：1987-12-01

Applicant: TORAY INDUSTRIES

Inventor： MUTOU MASANORI ,  MATSUNAGA KEIICHI ,  IMAMURA SHINZO ,  HANADA SATORU

IPC: A61K31/28 ,  A61K31/282 ,  A61K33/24 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I. USE:A remedy for malignant tumor, which is administered at a rate of 0.01-50mg/day. adult body weight. PREPARATION:An aqueous solution of dinitrato (1,2-diaminocyclohexane) platinum (II) expressed by formula II is passed through a column packed with an anion-exchange resin to afford dihydroxo (1,2-diaminocyclohexane) platinum (II) expressed by formula III, which is reacted with salicylaldehyde expressed by formula IV normally at ordinary temperature under ordinary pressure in an inert gas atmosphere using water as a solvent.

公开(公告)号：JPS5441839A

公开(公告)日：1979-04-03

申请号：JP10492977

申请日：1977-09-02

Applicant: TORAY INDUSTRIES

Inventor： YAMAZAKI TOORU ,  MATSUNAGA KEIICHI ,  HARADA ROKUROU

IPC: C07B61/00 ,  B01J25/00 ,  B01J25/02 ,  C07C67/00 ,  C07C227/00 ,  C07C227/08 ,  C07C229/38

Abstract: PURPOSE:The catalytic hydrogenation of p-formylbenzoic ester in the presence of ammonia is conducted by using a Raney nickel catalyst which is prepared by developing a Raney alloy containing 36-44wt% of nickel to produce title compound. CONSTITUTION:A binary Raney nickel alloy of 36-44wt% nickel and aluminum is developed to form a nickel catalyst. The catalytic hydrogenation of p-formylbenzoic ester is conducted together with ammonia in an amount of 3-6 times the amount of the ester in the presence of the above Raney nickel catalyst in 5-15% by volume as the powder/weight of the ester. The Raney alloy is developed by adding the powdery alloy to an aqueous sodium hydroxide solution under controling the emission of heat, washing with water, ethanol, then anhydrous ethanol, finally centrifuging.

公开(公告)号：JPS5152159A

公开(公告)日：1976-05-08

申请号：JP12486874

申请日：1974-10-31

Applicant: TORAY INDUSTRIES

Inventor： HARADA ROKURO ,  HARA MICHIO ,  ADACHI CHIAKI ,  MATSUNAGA KEIICHI

IPC: C07B61/00 ,  B01J23/00 ,  B01J23/38 ,  C07C67/00 ,  C07C231/00 ,  C07C231/10 ,  C07C233/47

公开(公告)号：JPH02279691A

公开(公告)日：1990-11-15

申请号：JP9837089

申请日：1989-04-18

Applicant: TORAY INDUSTRIES

Inventor： HASEGAWA SAKIE ,  MATSUNAGA KEIICHI ,  MUTOU MASATO ,  SAWAHATA TADASHI

IPC: C07D207/38 ,  A61K31/40 ,  A61K31/4015 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:2-(3-Acetylpyrrolidine-2,4-dione-5-yl)acetate-monohydroxo(tra ns-l- diaminocyclohexane) platinum (II) of formula I. USE:A treating agent of malignant tumor. PREPARATION:A platinum (II) compound of formula II [R is (NO3)2 or SO4], e.g. Pt (trans-l-1,2-diaminocyclohexane)(NO3)2] and an alkali earth metal hydroxide (e.g. sodium hydroxide) or a compound of formula III is reacted with compound of formula IV to provide the compound of formula I.

公开(公告)号：JPH01313488A

公开(公告)日：1989-12-18

申请号：JP14533888

申请日：1988-06-13

Applicant: TORAY INDUSTRIES

Inventor： MATSUNAGA KEIICHI ,  HASEGAWA SAKIE ,  MUTOU MASATO ,  HANADA SATORU

IPC: A61K31/28 ,  A61K31/282 ,  A61K31/34 ,  A61K31/40 ,  A61K33/24 ,  A61P35/00 ,  C07F15/00

Abstract: NEW MATERIAL:A compound expressed by formula I [X represents -O- or -NR - (R represents H or 1-12C alkyl); R represents 1-18C alkyl; R represents 1-18C alkyl, phenyl, benzyl, flourobenzyl or -CH2COY (Y represents -OCH3, -OC2H5 or -NH2C2H4OC2H5)]. EXAMPLE:3-Acetyl-6-methyltetrahydrofuran-2,4-dione-hydroxo(trans-l-1,2- diaminocyclochexane) platinum (II).monohydrate. USE:A remedy for malignant tumor. PREPARATION:A platinum (II) compound expressed by formula II is reacted with a compound expressed by formula III.