公开(公告)号：US20200095341A1

公开(公告)日：2020-03-26

申请号：US16465524

申请日：2017-11-30

Applicant: Universiteit Twente

Inventor： João Francisco Ribeiro Pereira Simões Crispim ,  Pascal Jonkheijm ,  Daniël Bart Frederik Saris

IPC: C07K17/08 ,  C07K14/47 ,  C07K16/22 ,  A61K47/59

Abstract: The disclosure relates to a biopolymer that is functionalized with a peptide, preferably a growth factor-binding peptide. The disclosure further relates to a device comprising a functionalized biopolymer, to methods for treatment of a tissue pathology in a subject using a device according to the disclosure, to methods for coupling peptides to carbonyl groups of a biopolymer, and to a use of oxygen plasma for coupling a peptide to carbonyl groups of a biopolymer.

公开(公告)号：US12275803B2

公开(公告)日：2025-04-15

申请号：US16465524

申请日：2017-11-30

Applicant: Universiteit Twente

Inventor： João Francisco Ribeiro Pereira Simões Crispim ,  Pascal Jonkheijm ,  Daniël Bart Frederik Saris

IPC: C07K17/08 ,  A61K47/59 ,  C07K14/47 ,  C07K16/22

Abstract: The disclosure relates to a biopolymer that is functionalized with a peptide, preferably a growth factor-binding peptide. The disclosure further relates to a device comprising a functionalized biopolymer, to methods for treatment of a tissue pathology in a subject using a device according to the disclosure, to methods for coupling peptides to carbonyl groups of a biopolymer, and to a use of oxygen plasma for coupling a peptide to carbonyl groups of a biopolymer.

公开(公告)号：US09636653B2

公开(公告)日：2017-05-02

申请号：US14431524

申请日：2013-09-24

Applicant: TECHNISCHE UNIVERSITEIT TWENTE ,  STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK

Inventor： Erhan Bat ,  Pascal Jonkheijm ,  Aart Van Amerongen ,  Jurriaan Hüskens

IPC: C40B60/14 ,  B01J19/00 ,  B05D1/18

CPC classification number: B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00619 ,  B01J2219/00659 ,  B05D1/18 ,  C40B60/14

Abstract: A stamp for making a microarray of biomolecules, wherein the stamp has a stamp body having a stamping surface for stamping the biomolecules onto a substrate, a plurality of reservoirs for liquids having the biomolecules, wherein each of the reservoirs has a bottom wall and a plurality of channels extending between each of the bottom wall and the stamping surface, wherein each of the reservoirs and the channels has a macroporous hydrogel and wherein the stamping surface is provided with a hydrophobic coating.

公开(公告)号：US09550345B2

公开(公告)日：2017-01-24

申请号：US14890982

申请日：2014-05-16

Applicant: UNIVERSITEIT TWENTE

Inventor： Jasper Van Weerd ,  Hermanus Bernardus Johannes Karperien ,  Pascal Jonkheijm

IPC: B32B27/06 ,  B32B17/06 ,  B32B15/04 ,  B32B18/00 ,  B32B27/36 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  C08G63/91

CPC classification number: B32B27/06 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  B32B15/04 ,  B32B17/06 ,  B32B18/00 ,  B32B27/36 ,  C08G63/912 ,  C08G63/916

Abstract: A process for the preparation of an object, supporting a lipid bilayer, for use in tissue engineering including the steps of providing an object having a surface, treating the surface of the object with a plasma containing active oxygen to provide the surface of the object with reactive groups A, to provide the surface of the object with reactive groups A, covalently attaching a sterol group to the reactive groups A and contacting the object activated with sterol groups with a lipid solution to form a lipid bilayer.

Abstract translation: 一种用于制备用于组织工程中的用于构成脂质双层的物体的方法，包括提供具有表面的物体的步骤，用含有活性氧的等离子体处理物体的表面以提供物体的表面 反应性基团A，以提供反应性基团A的表面，将甾醇基团共价连接到反应性基团A上，并将与甾醇基团活化的物质与脂质溶液接触以形成脂质双层。