公开(公告)号：GEP20217329B

公开(公告)日：2021-12-10

申请号：GEAP2017015057

申请日：2017-09-29

Applicant: VERTEX PHARMA

Inventor： MCCARTNEY JASON ,  VAN GOOR FREDRICK ,  ANDRESON COREY ,  FRIEMAN BRYAN A ,  KRENITSKY PAUL JOHN ,  MELILLO VITO ,  KHATUYA HARIPADA ,  CLEVELAND THOMAS ,  ZHANG BEILI ,  HUGHES ROBERT M ,  ALI KESHAVARZ-SHOKRI ALI ,  MCAULEY-AOKI RACHEL ,  TERMIN ANDREAS P ,  PIERRE FABRICE JEAN DENIS ,  UY JOHNNY ,  ABELA ALEXANDER RUSSELL ,  BUSCH BRETT BRADLEY ,  SIESEL DAVID ANDREW ,  ZHOU JINGLAN ,  HADIDA RUAH SARA SABINA ,  BAEK MINSON ,  GROOTENHUIS PETER ,  MILLER MARK THOMAS ,  ALCACIO TIMOTHY ,  JOSHI PRAMOD VIRUPAX ,  PARASELLI PRASUNA

IPC: C07D401/14 ,  A61K31/4439 ,  A61P11/12 ,  C07D471/14 ,  C07D498/14

Abstract: Compounds of Formula (I), (I), wherein values of Y1, Y2, X, R1, R2, R3, R4 substitudes and k, r, m, n, p, q variabels are provided in the claims, pharmaceutically acceptable salt and deuterated derivative thereof, and pharmaceutical usage therefor the treatment of mucoviscidose. s Table: 9