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公开(公告)号：AR120708A2
公开(公告)日：2022-03-09
申请号：ARP200103429
申请日：2020-12-10
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , HARIPADA KHATUYA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN , CHIEH - MARELIUS GULIN ERDGOGAN , MELILLO VITO , MCARTNEY JASON , NICHOLLS GEORGIA MGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: C07D231/14 , A61K31/415
Abstract: Se proveen además composiciones farmacéuticas que comprenden a éstos compuestos junto con otro u otros agentes terapéuticos adicionales.
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2.发明专利
公开(公告)号：CO2021014204A2
公开(公告)日：2021-10-29
申请号：CO2021014204
申请日：2021-10-25
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER , ANDERSON COREY DON , CLEVELAND THOMAS , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , ABRAHAM SUNNY , ARUMUGAM VIJAYALAKSMI , CHAU JACLYN , CLEMENS JEREMY , DWIGHT TIMOTHY A , FRIEMAN BRYAN A , ISHIHARA YOSHIHIRO , KRENITSKY PAUL , MELILLO VITO , SILINA ALINA , UY JOHNNY
IPC: A61P11/00 , C07D239/69 , C07D515/08
Abstract: Se describen el compuesto I, derivados deuterados y sales farmacéuticamente aceptables de cualquiera de los precedentes. También se describen métodos para tratar la fibrosis cística utilizando dichos compuestos.
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公开(公告)号：HRP20201603T1
公开(公告)日：2021-02-19
申请号：HRP20201603
申请日：2020-10-07
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
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公开(公告)号：MA41051B1
公开(公告)日：2020-11-30
申请号：MA41051
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
Abstract: La présente invention concerne un composé de formule (i): (i) ou un sel pharmaceutiquement acceptable de celui-ci, où r1, r2, r3, w, x, y, z, n, o, p et q sont tels que définis dans la description, lequel composé est utile pour le traitement de maladies médiées par le cftr, telles que la mucoviscidose. La présente invention concerne également des compositions pharmaceutiques, une méthode de traitement et des kits correspondants.
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公开(公告)号：SI3203840T1
公开(公告)日：2020-10-30
申请号：SI201531355
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： MILLER MARK THOMAS , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MELILLO VITO , MCCARTNEY JASON , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A61K31/00 , A01N41/00 , C07D209/00 , C07D213/00 , C07D231/00 , C07D235/00 , C07D239/00 , C07D401/00 , C07D403/00 , C07D407/00 , C07D413/00
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Patent Agency Ranking
公开(公告)号：SG10201913595YA
公开(公告)日：2020-02-27
申请号：SG10201913595Y
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
Abstract: Compounds of Formula I:pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：CR20190211A
公开(公告)日：2019-07-11
申请号：CR20190211
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： MCCARTNEY JASON , ANDERSON COREY , CLEVELAND THOMAS , JOSHI PRAMOD VIRUPAX , ZHOU JINGLAN , BAEK MINSON , FRIEMAN BRYAN A , BUSCH BRETT BRADLEY , SIESEL DAVID ANDREW , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , VAN GOOR FREDRICK , TERMIN ANDREAS P , PARASELLI PRASUNA , GROOTENHUIS PETER , HUGHES ROBERT M , ALCACIO TIMOTHY , HADIDA RUAH SARA SABINA , ZHANG BEILI , KRENITSKY PAUL JOHN , UY JOHNNY , KHATUYA HARIPADA; , MELILLO VITO; , MILLER MARK THOMAS , PIERRE FABRICE JEAN DENIS , ABELA ALEXANDER RUSSELL
IPC: C07D471/14 , A61K31/4439 , A61P11/12 , C07B59/00 , C07D401/14 , C07D498/14
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公开(公告)号：CA3019380A1
公开(公告)日：2017-10-05
申请号：CA3019380
申请日：2017-03-31
Applicant: VERTEX PHARMA
Inventor： BEAR BRIAN , CLEMENS JEREMY , CLEVELAND THOMAS , COON TIMOTHY RICHARD , GROOTENHUIS PETER DIEDERIK JAN , FRIEMAN BRYAN A , HADIDA RUAH SARA S , KHATUYA HARIPADA , KRENITSKY PAUL J , MILLER MARK THOMAS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/44 , A61P11/00 , C07D213/82
Abstract: The present disclosure features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, W, X, Z, n, p, and Rings A and B are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present disclosure also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：MA41051A
公开(公告)日：2017-08-16
申请号：MA41051
申请日：2015-10-06
Applicant: VERTEX PHARMA
Inventor： ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , BEAR BRIAN RICHARD , BINCH HAYLEY MARIE , CLEMENS JEREMY J , CLEVELAND THOMAS , CONROY ERICA , COON TIMOTHY RICHARD , FRIEMAN BRYAN A , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , HADIDA-RUAH SARA SABINA , JOSHI PRAMOD VIRUPAX , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , LIN CHUN-CHIEH , MARELIUS GULIN ERDOGAN , MCCARTNEY JASON , MELILLO VITO , MILLER MARK THOMAS , NICHOLLS GEORGIA MCGAUGHEY , PIERRE FABRICE JEAN DENIS , SILINA ALINA , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN
IPC: A01N41/06 , A61K31/18 , C07D209/18 , C07D209/49 , C07D213/64 , C07D213/73 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D403/10 , C07D403/12 , C07D407/12 , C07D413/14
Abstract: La présente invention concerne un composé de formule (i): (i) ou un sel pharmaceutiquement acceptable de celui-ci, où r1, r2, r3, w, x, y, z, n, o, p et q sont tels que définis dans la description, lequel composé est utile pour le traitement de maladies médiées par le cftr, telles que la mucoviscidose. La présente invention concerne également des compositions pharmaceutiques, une méthode de traitement et des kits correspondants.
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10.发明专利
公开(公告)号：JOP20190042A1
公开(公告)日：2017-06-16
申请号：JOP20190042
申请日：2019-03-11
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , BAEK MINSON , ZHANG BEILI , UY JOHNNY , ZHOU JINGLAN , JOSHI PRAMOD VIRUPAX , SIESEL DAVID ANDREW , BUSCH BRETT BRADLEY , GROOTENHUIS PETER , VAN GOOR FREDRICK , KESHAVARZ-SHOKRI ALI , MELILLO VITO , HUGHES ROBERT M , ANDERSON COREY , ALCACIO TIMOTHY , PARASELLI PRASUNA , KHATUYA HARIPADA , FRIEMAN BRYAN A , CLEVELAND THOMAS , PIERRE FABRICE JEAN DENIS , KRENITSKY PAUL JOHN , MCCARTNEY JASON , TERMIN ANDREAS P , MCAULEY-AOKI RACHEL , MILLER MARK THOMAS , HADIDA RUAH SARA SABINA
Abstract: ( I )، يتمالكشفعنمركباتلهاالصيغة ( I )،أملاحمقبولةصيدليًامنها،مشتقاتمعالجةبالديوتيريوممنأيٍمماسبق،ونواتجأيضلأيٍمماسبق. كمايتمالكشفعنتركيباتصيدليةتشتملعليها،طرقلعلاجالتليفالكيسيباستخدامها،وطرقلتصنيعها.
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