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公开(公告)号：EA039280B1
公开(公告)日：2021-12-28
申请号：EA201991403
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TIMOTHY JOHN , ZHOU JINGLAN
Abstract: Визобретенииописанымодуляторрегуляторатрансмембраннойпроводимостипримуковисцидозе (CFTR) формулы 1, атакжеегодейтерированноепроизводное, фармацевтическиекомпозиции, содержащиеуказанныймодулятор, испособылечениямуковисцидоза.
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公开(公告)号：MA49752A
公开(公告)日：2021-04-21
申请号：MA49752
申请日：2018-08-02
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL T , HUGHES ROBERT M , LEWANDOWSKI BERENICE , LITTLER BENJAMIN J , NUGENT WILLIAM A , SMITH DAVID , STUDLEY JOHN
IPC: C07D207/06 , C07D207/263
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公开(公告)号：MA49235A
公开(公告)日：2019-10-16
申请号：MA49235
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: A61P11/00 , A61K31/455 , C07D231/20 , C07D401/04 , C07D401/14
Abstract: L'invention concerne des composés de formule (i) des sels pharmaceutiquement acceptables de ceux-ci, des dérivés deutérés et des métabolites de l'un quelconque des précédents. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention, des procédés de traitement de la fibrose kystique à l'aide de celles-ci, et des procédés de fabrication de celles-ci. L'invention concerne en outre des formes à l'état solide du composé 1, des sels et des solvates de celui-ci.
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公开(公告)号：PE20191304A1
公开(公告)日：2019-09-23
申请号：PE2019001200
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , VAN GOOR FREDRICK , YOUNG TOMOTHY JOHN , ZHOU JINGLAN , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , GROOS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
Abstract: Referido a un compuesto de formula I, su sal farmaceuticamente aceptable o un derivado deuterado del mismo, en donde: uno de Y1 e Y2 es N el otro es CH; X es N(alquilo C1-C4), O u NH; R1 es -(C(R2)2)k-O-(C(R2)2)mR7; cada R2 es H, halogeno, ente otros; cada R3 es alquilo C1-C4 sustituido opcionalmente, entre otros; K es 0 o 1; r es 0 o 1; m es 0, 1, 2 o 3; p es p, 1 o 2; y q es 0, 1, 2, 3, 4, 5, 6, 7 u 8. Estos compuestos modulan el regulador de conductancia transmembrana de fibrosis quistica (CFTR); tambien se refiere a metodos de preparacion de dichos compuestos, sus compuestos intermedios y una composicion farmaceutica que los contiene.
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公开(公告)号：CO2019004065A2
公开(公告)日：2019-04-30
申请号：CO2019004065
申请日：2019-04-24
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
IPC: C07D401/14 , A61K31/4439 , A61P11/12 , C07D471/14 , C07D498/14
Abstract: Compuestos de Fórmula I: sales farmacéuticamente aceptables de este, derivados deuterados de cualquiera de los precedentes y metabolitos de cualquiera de los precedentes se describen. También se describen composiciones farmacéuticas que los comprenden, métodos para tratar la fibrosis quística usándolos y métodos para producirlos.
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Patent Agency Ranking
公开(公告)号：SI3551622T1
公开(公告)日：2021-02-26
申请号：SI201730537
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/00 , A61K31/00 , A61P11/00 , C07D231/00
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公开(公告)号：RS61150B1
公开(公告)日：2020-12-31
申请号：RSP20201477
申请日：2017-12-08
Applicant: VERTEX PHARMA
Inventor： ABELA ALEXANDER RUSSELL , ALCACIO TIMOTHY , ANDERSON COREY , ANGELL PAUL TIMOTHY , BAEK MINSON , CLEMENS JEREMY J , CLEVELAND THOMAS , FERRIS LORI ANN , GROOTENHUIS PETER DIEDERIK JAN , GROSS RAYMOND STANLEY , GULEVICH ANTON , HADIDA RUAH SARA SABINA , HSIA CLARA KUANG-JU , HUGHES ROBERT M , JOSHI PRAMOD VIRUPAX , KANG PING , KESHAVARZ-SHOKRI ALI , KHATUYA HARIPADA , KRENITSKY PAUL JOHN , MCCARTNEY JASON , MILLER MARK THOMAS , PARASELLI PRASUNA , PIERRE FABRICE JEAN DENIS , SHI YI , SHRESTHA MUNA , SIESEL DAVID ANDREW , STAVROPOULOS KATHY , TERMIN ANDREAS P , UY JOHNNY , VAN GOOR FREDRICK F , YOUNG TOMOTHY JOHN , ZHOU JINGLAN
IPC: C07D401/14 , A61K31/455 , A61P11/00 , C07D231/20 , C07D401/04
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公开(公告)号：SG10201913595YA
公开(公告)日：2020-02-27
申请号：SG10201913595Y
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： ALCACIO TIMOTHY , BAEK MINSON , GROOTENHUIS PETER , HADIDA RUAH SARA SABINA , HUGHES ROBERT M , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , MCCARTNEY JASON , MILLER MARK THOMAS , VAN GOOR FREDRICK , ZHANG BEILI , ANDERSON COREY , CLEVELAND THOMAS , FRIEMAN BRYAN A , KHATUYA HARIPADA , JOSHI PRAMOD VIRUPAX , KRENITSKY PAUL JOHN , MELILLO VITO , PIERRE FABRICE JEAN DENIS , TERMIN ANDREAS P , UY JOHNNY , ZHOU JINGLAN , ABELA ALEXANDER RUSSELL , BUSCH BRETT BRADLEY , PARASELLI PRASUNA , SIESEL DAVID ANDREW
Abstract: Compounds of Formula I:pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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公开(公告)号：CR20190211A
公开(公告)日：2019-07-11
申请号：CR20190211
申请日：2017-09-29
Applicant: VERTEX PHARMA
Inventor： MCCARTNEY JASON , ANDERSON COREY , CLEVELAND THOMAS , JOSHI PRAMOD VIRUPAX , ZHOU JINGLAN , BAEK MINSON , FRIEMAN BRYAN A , BUSCH BRETT BRADLEY , SIESEL DAVID ANDREW , KESHAVARZ-SHOKRI ALI , MCAULEY-AOKI RACHEL , VAN GOOR FREDRICK , TERMIN ANDREAS P , PARASELLI PRASUNA , GROOTENHUIS PETER , HUGHES ROBERT M , ALCACIO TIMOTHY , HADIDA RUAH SARA SABINA , ZHANG BEILI , KRENITSKY PAUL JOHN , UY JOHNNY , KHATUYA HARIPADA; , MELILLO VITO; , MILLER MARK THOMAS , PIERRE FABRICE JEAN DENIS , ABELA ALEXANDER RUSSELL
IPC: C07D471/14 , A61K31/4439 , A61P11/12 , C07B59/00 , C07D401/14 , C07D498/14
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公开(公告)号：CA3085006A1
公开(公告)日：2019-06-13
申请号：CA3085006
申请日：2018-12-07
Applicant: VERTEX PHARMA
Inventor： ANGELL PAUL T , HARRISON CRISTIAN , HUGHES ROBERT M , LEWANDOWSKI BERENICE , LITTLER BENJAMIN J , MELILLO VITO , NUGENT WILLIAM A , SIESEL DAVID ANDREW , SMITH DAVID , STUDLEY JOHN
IPC: C07D401/14 , C07D231/20 , C07D401/04 , C07D405/04
Abstract: The disclosure provides processes for preparing a compound of Formula (I).
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