公开(公告)号：AU3280901A

公开(公告)日：2001-07-31

申请号：AU3280901

申请日：2001-01-16

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL ,  BELLON STEVE ,  STAMOS DEAN ,  BADIA MICHAEL ,  GRILLOT ANNE-LAURE ,  RONKIN STEVEN ,  MURCKO MARK ,  TRUDEAU MARTIN

IPC: A61K31/4155 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61P31/04 ,  C12Q1/25 ,  G06F19/16 ,  G06F19/18

Abstract: Disclosed herein are compounds comprising the pharmacophore features HBA, HBD, Grpl, and at least two features selected from Grp2, Grp3 or Grp4 in which HBA is a hydrogen bond acceptor, HBD is a hydrogen bond donor, and Grps 1-4 are as described in the specification. The compounds are inhibitors of bacterial DNA gyrase and are useful in treating bacterial infections. The pharmacophore features may be used to identify and design new inhibitors.