公开(公告)号：WO2008106151A3

公开(公告)日：2008-11-06

申请号：PCT/US2008002568

申请日：2008-02-27

Applicant: VERTEX PHARMA ,  CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

CPC classification number: C07K5/0812 ,  C07D403/12

Abstract: The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.

Abstract translation: 本发明涉及各自包含VX-950和选自4-羟基苯甲酸，4-氨基水杨酸，苯丙氨酸，苏氨酸，酒石酸，己二酸，琥珀酸乙酯， 脯氨酸，4-羟基苯甲酸甲酯，邻氨基苯甲酸和d-生物素。 在本发明的范围内也是制造和使用本发明的方法。

公开(公告)号：WO2007098270A3

公开(公告)日：2007-10-25

申请号：PCT/US2007004995

申请日：2007-02-27

Applicant: VERTEX PHARMA ,  CONNELLY PATRICK R

Inventor： CONNELLY PATRICK R

IPC: A61K31/497 ,  A61K31/60 ,  A61P31/12 ,  C07D403/02

CPC classification number: C07D403/12 ,  A61K31/191 ,  A61K31/375 ,  A61K38/06 ,  C12N2770/24222 ,  A61K2300/00

Abstract: The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of salicylic acid, 4-amino salicylic acid, and oxalic acid. Also within the scope of this invention are methods of making and using the same.

Abstract translation: 本发明涉及各自包含VX-950和选自水杨酸，4-氨基水杨酸和草酸的共结晶形成体的组合物和共晶体。 在本发明的范围内也是制造和使用本发明的方法。

公开(公告)号：NZ583699A

公开(公告)日：2012-04-27

申请号：NZ58369908

申请日：2008-08-29

Applicant: VERTEX PHARMA

Inventor： ZHANG YUEGANG ,  CONNELLY PATRICK R ,  JOHNSTON STEVE

IPC: C07D403/12 ,  A61K31/454 ,  A61P1/16

Abstract: Disclosed is a co-crystal comprising a compound of formula I (commonly known as telaprevir or VX-950) and a co-crystal former selected from the group consisting of 3-methoxy-4-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid.

公开(公告)号：MX2009009182A

公开(公告)日：2009-09-04

申请号：MX2009009182

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: A61K31/497 ,  C07D403/12 ,  A61K38/07 ,  C07K5/10

Abstract: La invención se refiere a composiciones y co-cristales cada uno comprendiendo VX-950 y formador de co-cristal seleccionado del grupo que consiste de ácido 4-hidroxibenzoico, ácido 4-aminosalicílico, feriilalanina, treonlina, ácido tartárico, ácido adípico, acetato succínico, prolina, 4-hidroxobenzoato de metilo, ácido antranílico y d-Biotina. También dentro del alcance de esta invención están los métodos para hacer y utilizar los mismos.

公开(公告)号：CY1112865T1

公开(公告)日：2016-04-13

申请号：CY121100380

申请日：2012-04-23

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

Abstract: Ηεφεύρεσηαφοράσυνθέσειςκαισυν-κρυστάλλους, οκαθέναςαπότουςοποίουςπεριέχει VΧ-950 καιμιαμήτρασυν-κρυστάλλου, ηοποίαεπιλέγεταιαπότηνομάδαπουαποτελείταιαπό 4-υδροξυβενζοϊκόοξύ, 4-αμινοσαλικυλικόοξύ, φαινυλαλανίνη, θρεονίνη, ταρταρικόοξύ, αδιπικόοξύ, οξικόεστέρατουηλεκτρικούοξέος, προλίνη, 4-υδροξυβενζοϊκόμεθυλεστέρα, ανθρανιλικόοξύκαι d-βιοτίνη. Επίσηςστοεύροςτηςπαρούσαςεφεύρεσηςεμπίπτουνοιμέθοδοιγιατηνπαρασκευήκαιτηνχρήσητους.

公开(公告)号：ES2379905T3

公开(公告)日：2012-05-04

申请号：ES08726147

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

Abstract: Un co-cristal que comprende un compuesto que tiene la estructura y ácido 4-hidroxibenzoico.

公开(公告)号：ECSP099600A

公开(公告)日：2009-09-29

申请号：ECSP099600

申请日：2009-08-27

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KIDIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS

IPC: A61K31/497 ,  A61K31/60 ,  A61P31/12 ,  C07D403/02

Abstract: La presente invención se refiere a composiciones que contienen un inhibidor (VX-950) de la hepatitis C y un específico co-cristal. Este inhibidor que tiene la estructura que se muestra a continuación es un compuesto que es muy necesitado para inhibir la hepatitis C.

公开(公告)号：CA2679312A1

公开(公告)日：2008-09-04

申请号：CA2679312

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： KADIYALA IRINA ,  ROSE PETER ,  STAVROPOLUS KATHY ,  CONNELLY PATRICK R ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ZHANG YUEGANG ,  JOHNSTON STEVE

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

Abstract: The invention relates to compositions and co-crystals each comprising VX- 950 and a co-crystal former selected from the group consisting of 4-hydroxyb enzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric aci d, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthran ilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.

公开(公告)号：AU2007217355A1

公开(公告)日：2007-08-30

申请号：AU2007217355

申请日：2007-02-27

Applicant: VERTEX PHARMA

Inventor： MORISETTE SHERRY ,  TAUBER MICHAEL ,  CONNELLY PATRICK R

IPC: A61K31/497 ,  A61K31/60 ,  A61P31/12 ,  C07D403/02

Abstract: The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of salicylic acid, 4-amino salicylic acid, and oxalic acid. Also within the scope of this invention are methods of making and using the same.

公开(公告)号：GEP20125645B

公开(公告)日：2012-09-25

申请号：GEAP2008011488

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

Abstract: The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making the same.