公开(公告)号：WO2008106151A3

公开(公告)日：2008-11-06

申请号：PCT/US2008002568

申请日：2008-02-27

Applicant: VERTEX PHARMA ,  CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

CPC classification number: C07K5/0812 ,  C07D403/12

Abstract: The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.

Abstract translation: 本发明涉及各自包含VX-950和选自4-羟基苯甲酸，4-氨基水杨酸，苯丙氨酸，苏氨酸，酒石酸，己二酸，琥珀酸乙酯， 脯氨酸，4-羟基苯甲酸甲酯，邻氨基苯甲酸和d-生物素。 在本发明的范围内也是制造和使用本发明的方法。

公开(公告)号：AU2008219607B2

公开(公告)日：2013-09-12

申请号：AU2008219607

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： JOHNSTON STEVE ,  STAVROPOLUS KATHY ,  JURKAUSKAS VALDAS ,  BHISETTI GOVINDA RAO ,  ZHANG YUEGANG ,  CONNELLY PATRICK R ,  ROSE PETER ,  KADIYALA IRINA

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

Abstract: The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.

公开(公告)号：SI2114924T1

公开(公告)日：2012-06-29

申请号：SI200830602

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/00 ,  A61K31/00 ,  A61K38/00 ,  C07K5/00

公开(公告)号：DK2114924T3

公开(公告)日：2012-04-10

申请号：DK08726147

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

公开(公告)号：NZ579442A

公开(公告)日：2012-02-24

申请号：NZ57944208

申请日：2008-02-27

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK R ,  KADIYALA IRINA ,  STAVROPOLUS KATHY ,  ZHANG YUEGANG ,  JOHNSTON STEVE ,  BHISETTI GOVINDA RAO ,  JURKAUSKAS VALDAS ,  ROSE PETER

IPC: C07D403/12 ,  A61K31/497 ,  A61K38/07 ,  C07K5/10

Abstract: Disclosed is a co-crystal comprising (1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide (Telaprevir) and 4-hydroxybenzoic acid.

公开(公告)号：SG175800A1

公开(公告)日：2011-12-29

申请号：SG2011078581

申请日：2010-04-27

Applicant: VERTEX PHARMA

Inventor： TANOURY GERALD J ,  CHEN MINZHANG ,  COCHRAN JOHN E ,  LOOKER ADAM ,  JURKAUSKAS VALDAS

Abstract: The invention relates to compounds and processes u useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.

公开(公告)号：AU2009288200A1

公开(公告)日：2010-03-11

申请号：AU2009288200

申请日：2009-08-28

Applicant: VERTEX PHARMA

Inventor： DOKOU ELENI ,  GASPARAC REHELA ,  KNEZIC DRAGUTIN ,  KLINE BILLIE ,  JURKAUSKAS VALDAS

IPC: A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48

Abstract: An immediate release formulation of an active ingredient.

公开(公告)号：SI3068776T1

公开(公告)日：2019-09-30

申请号：SI201431295

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME W ,  WALDO MICHAEL ,  O'NEIL SIMON ADAM ,  VAN ALSTEN JOHN GREGG ,  MACIKENAS DAINIUS ,  MUDUNURI PRAVEEN ,  SHI YI ,  LEDEBOER MARK WILLEM ,  JURKAUSKAS VALDAS ,  MEDEK ALES ,  JONES STEVEN ,  BYRN RANDAL ,  ASMAL MOHAMMED ,  ROBERTSON SARAH MARIE ,  TSAI WANJUNG

IPC: C07D403/00 ,  A61K31/00 ,  A61P31/00 ,  C07D471/00

公开(公告)号：RS59144B1

公开(公告)日：2019-09-30

申请号：RSP20191054

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： NTI-ADDAE KWAME W ,  WALDO MICHAEL ,  O'NEIL SIMON ADAM ,  VAN ALSTEN JOHN GREGG ,  MACIKENAS DAINIUS ,  MUDUNURI PRAVEEN ,  SHI YI ,  LEDEBOER MARK WILLEM ,  JURKAUSKAS VALDAS ,  MEDEK ALES ,  JONES STEVEN ,  BYRN RANDAL ,  ASMAL MOHAMMED ,  ROBERTSON SARAH MARIE ,  TSAI WANJUNG

IPC: C07D403/04 ,  A61K31/506 ,  A61P31/16 ,  C07D471/04

公开(公告)号：DK3068776T3

公开(公告)日：2019-07-29

申请号：DK14802787

申请日：2014-11-12

Applicant: VERTEX PHARMA

Inventor： WALDO MICHAEL ,  O'NEIL SIMON ADAM ,  MACIKENAS DAINIUS ,  SHI YI ,  LEDEBOER MARK WILLEM ,  JURKAUSKAS VALDAS ,  MEDEK ALES ,  JONES STEVEN ,  BYRN RANDAL ,  ASMAL MOHAMMED ,  ROBERTSON SARAH MARIE ,  TSAI WANJUNG ,  NTI-ADDAE KWAME W ,  VAN ALSTEN JOHN GREGG ,  MUDUNURI PRAVEEN

IPC: C07D403/04 ,  A61K31/506 ,  A61P31/16 ,  C07D471/04